- Trastuzumab (herceptin) targets gastric cancer stem cells characterized by CD90 phenotype
[作者：Jiang, J; Zhang, Y; Chuai, S; Wang, Z; Zheng, D; Xu, F; Zhang, Y; Li, C; Liang, Y; Chen, Z,期刊：Oncogene, 页码：671-682 , 文章类型： Article，,卷期：2012年31-6]
- Identification and characterization of cancer stem cells (CSCs) in gastric cancer are difficult owing to the lack of specific markers and consensus methods. In this study, we show that cells with the CD90 surface marker ...
- Death-associated protein kinase increases glycolytic rate through binding and activation of pyruvate kinase
[作者：Mor, I; Carlessi, R; Ast, T; Feinstein, E; Kimchi, A,期刊：Oncogene, 页码：683-693 , 文章类型： Article，,卷期：2012年31-6]
- Death-associated protein kinase (DAPk), a multi-domain serine/threonine kinase, regulates numerous cell death mechanisms and harbors tumor suppressor functions. In this study, we report that DAPk directly binds and funct...
- Sex differences in the GSK3 beta-mediated survival of adherent leukemic progenitors
[作者：Bertrand, J; Despeaux, M; Joly, S; Bourogaa, E; Gallay, N; Demur, C; Bonnevialle, P; Louache, F; Maguer-Satta, V; Vergnolle, N; Payrastre, B; Racaud-Sultan, C,期刊：Oncogene, 页码：694-705 , 文章类型： Article，,卷期：2012年31-6]
- Therapeutic resistance of acute myeloid leukemia stem cells, enriched in the CD34(+)38(-)123(+) progenitor population, is supported by extrinsic factors such as the bone marrow niche. Here, we report that when adherent o...
- Phosphoinositide 3-kinase signaling is critical for ErbB3-driven breast cancer cell motility and metastasis
[作者：Smirnova, T; Zhou, ZN; Flinn, RJ; Wyckoff, J; Boimel, PJ; Pozzuto, M; Coniglio, SJ; Backer, JM; Bresnick, AR; Condeelis, JS; Hynes, NE; Segall, JE,期刊：Oncogene, 页码：706-715 , 文章类型： Article，,卷期：2012年31-6]
- Many malignancies show increased expression of the epidermal growth factor (EGF) receptor family member ErbB3 (HER3). ErbB3 binds heregulin beta-1 (HRG beta 1) and forms a heterodimer with other ErbB family members, such...
- A novel nuclear role for the Vav3 nucleotide exchange factor in androgen receptor coactivation in prostate cancer
[作者：Rao, S; Lyons, LS; Fahrenholtz, CD; Wu, F; Farooq, A; Balkan, W; Burnstein, KL,期刊：Oncogene, 页码：716-727 , 文章类型： Article，,卷期：2012年31-6]
- Increased androgen receptor (AR) transcriptional activity mediated by coactivator proteins may drive castration-resistant prostate cancer (CRPC) growth. Vav3, a Rho GTPase guanine nucleotide exchange factor (GEF), is ove...
- Anti-angiogenic and tumor-suppressive roles of candidate tumor-suppressor gene, Fibulin-2, in nasopharyngeal carcinoma
[作者：Law, EWL; Cheung, AKL; Kashuba, VI; Pavlova, TV; Zabarovsky, ER; Lung, HL; Cheng, Y; Chua, D; Kwong, DLW; Tsao, SW; Sasaki, T; Stanbridge, EJ; Lung, ML,期刊：Oncogene, 页码：728-738 , 文章类型： Article，,卷期：2012年31-6]
- Fibulin-2 (FBLN2) has been identified as a candidate tumor-suppressor gene in nasopharyngeal carcinoma (NPC). Originally identified through a chromosome 3 NotI genomic microarray screen, it shows frequent deletion or met...
- Regulated ATF5 loss-of-function in adult mice blocks formation and causes regression/eradication of gliomas
[作者：Arias, A; Lame, MW; Santarelli, L; Hen, R; Greene, LA; Angelastro, JM,期刊：Oncogene, 页码：739-751 , 文章类型： Article，,卷期：2012年31-6]
- Glioblastomas are among the most incurable cancers. Our past findings indicated that glioblastoma cells, but not neurons or glia, require the transcription factor ATF5 (activating transcription factor 5) for survival. Ho...
- Regulation of ovarian cancer progression by microRNA-187 through targeting Disabled homolog-2
[作者：Chao, A; Lin, CY; Lee, YS; Tsai, CL; Wei, PC; Hsueh, S; Wu, TI; Tsai, CN; Wang, CJ; Chao, AS; Wang, TH; Lai, CH,期刊：Oncogene, 页码：764-775 , 文章类型： Article，,卷期：2012年31-6]
- MicroRNAs (miRNAs) play important roles in tumorigenesis by regulating oncogenes and tumor-suppressor genes. In this study, miR-187 and miR-200a were found to be expressed at higher levels in ovarian cancers than in beni...
- The von Hippel-Lindau tumor suppressor protein regulates gene expression and tumor growth through histone demethylase JARID1C
[作者：Niu, X; Zhang, T; Liao, L; Zhou, L; Lindner, DJ; Zhou, M; Rini, B; Yan, Q; Yang, H,期刊：Oncogene, 页码：776-786 , 文章类型： Article，,卷期：2012年31-6]
- In clear-cell renal cell carcinoma (ccRCC), inactivation of the tumor suppressor von Hippel-Lindau (VHL) occurs in the majority of the tumors and is causal for the pathogenesis of ccRCC. Recently, a large-scale genomic s...
- Neutralization of the gamma-secretase activity by monoclonal antibody against extracellular domain of nicastrin
[作者：Hayashi, I; Takatori, S; Urano, Y; Miyake, Y; Takagi, J; Sakata-Yanagimoto, M; Iwanari, H; Osawa, S; Morohashi, Y; Li, T; Wong, PC; Chiba, S; Kodama, T; Hamakubo, T; Tomita, T; Iwatsubo, T,期刊：Oncogene, 页码：787-798 , 文章类型： Article，,卷期：2012年31-6]
- Several lines of evidence suggest that aberrant Notch signaling contributes to the development of several types of cancer. Activation of Notch receptor is executed through intramembrane proteolysis by gamma-secretase, wh...
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