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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共11条记录   Standard of care therapy for malignant glioma and its effect on tumor and stromal cells [作者：Jones, TS; Holland, EC,期刊：Oncogene, 页码：1995-2006 , 文章类型： Review，,卷期：2012年31-16] Glioblastoma is the most common and deadly of the primary central nervous system tumors. Recent advances in molecular characterization have subdivided these tumors into at least three main groups. In addition, these tumo... Activation of tumor cell proliferation by thyroid hormone in a mouse model of follicular thyroid carcinoma [作者：Lu, C; Zhu, X; Willingham, MC; Cheng, SY,期刊：Oncogene, 页码：2007-2016 , 文章类型： Article，,卷期：2012年31-16] Thyroid cancers are the most common malignancy of the endocrine system in humans. To understand the molecular genetic events underlying thyroid carcinogenesis, we have generated a mouse model that spontaneously develops ... GATA3 inhibits lysyl oxidase-mediated metastases of human basal triple-negative breast cancer cells [作者：Chu, IM; Michalowski, AM; Hoenerhoff, M; Szauter, KM; Luger, D; Sato, M; Flanders, K; Oshima, A; Csiszar, K; Green, JE,期刊：Oncogene, 页码：2017-2027 , 文章类型： Article，,卷期：2012年31-16] Discovery of mechanisms that impede the aggressive and metastatic phenotype of human basal triple-negative-type breast cancers (BTNBCs) could provide novel targets for therapy for this form of breast cancer that has a re... Different phenotypic consequences of simultaneous versus stepwise Apc loss [作者：Fischer, JM; Miller, AJ; Shibata, D; Liskay, RM,期刊：Oncogene, 页码：2028-2038 , 文章类型： Article，,卷期：2012年31-16] APC is considered a gatekeeper for colorectal cancer (CRC). Cells with heterozygous APC mutations have altered expression profiles suggesting that the first APC hit may help set the stage for subsequent transformation. T... Identification of microprocessor-dependent cancer cells allows screening for growth-sustaining micro-RNAs [作者：Peric, D; Chvalova, K; Rousselet, G,期刊：Oncogene, 页码：2039-2048 , 文章类型： Article，,卷期：2012年31-16] Micro-RNAs are deregulated in cancer cells, and some are either tumor suppressive or oncogenic. In addition, a link has been established between decreased expression of micro-RNAs and transformation, and several proteins... The new truncated somatostatin receptor variant sst5TMD4 is associated to poor prognosis in breast cancer and increases malignancy in MCF-7 cells [作者：Duran-Prado, M; Gahete, MD; Hergueta-Redondo, M; Martinez-Fuentes, AJ; Cordoba-Chacon, J; Palacios, J; Gracia-Navarro, F; Moreno-Bueno, G; Malagon, MM; Luque, RM; Castano, JP,期刊：Oncogene, 页码：2049-2061 , 文章类型： Article，,卷期：2012年31-16] Somatostatin receptors (sst1-5) are present in different types of tumors, where they inhibit key cellular processes such as proliferation and invasion. Although ssts are densely expressed in breast cancer, especially sst... Dynamic epigenetic regulation of the microRNA-200 family mediates epithelial and mesenchymal transitions in human tumorigenesis [作者：Davalos, V; Moutinho, C; Villanueva, A; Boque, R; Silva, P; Carneiro, F; Esteller, M,期刊：Oncogene, 页码：2062-2074 , 文章类型： Article，,卷期：2012年31-16] Epithelial-mesenchymal (EMT) and mesenchymal-epithelial (MET) transitions occur in the development of human tumorigenesis and are part of the natural history of the process to adapt to the changing microenvironment. In t... Lysophosphatidic acid and sphingosine-1-phosphate promote morphogenesis and block invasion of prostate cancer cells in three-dimensional organotypic models [作者：Harma, V; Knuuttila, M; Virtanen, J; Mirtti, T; Kohonen, P; Kovanen, P; Happonen, A; Kaewphan, S; Ahonen, I; Kallioniemi, O; Grafstrom, R; Lotjonen, J; Nees, M,期刊：Oncogene, 页码：2075-2089 , 文章类型： Article，,卷期：2012年31-16] Normal prostate and some malignant prostate cancer (PrCa) cell lines undergo acinar differentiation and form spheroids in three-dimensional (3-D) organotypic culture. Acini formed by PC-3 and PC-3M, less pronounced also ... An integrated genomic approach identifies ARID1A as a candidate tumor-suppressor gene in breast cancer [作者：Mamo, A; Cavallone, L; Tuzmen, S; Chabot, C; Ferrario, C; Hassan, S; Edgren, H; Kallioniemi, O; Aleynikova, O; Przybytkowski, E; Malcolm, K; Mousses, S; Tonin, PN; Basik, M,期刊：Oncogene, 页码：2090-2100 , 文章类型： Article，,卷期：2012年31-16] Tumor-suppressor genes (TSGs) have been classically defined as genes whose loss of function in tumor cells contributes to the formation and/or maintenance of the tumor phenotype. TSGs containing nonsense mutations may no... Nuclear transport receptor karyopherin-alpha 2 promotes malignant breast cancer phenotypes in vitro [作者：Noetzel, E; Rose, M; Bornemann, J; Gajewski, M; Knuchel, R; Dahl, E,期刊：Oncogene, 页码：2101-2114 , 文章类型： Article，,卷期：2012年31-16] Tumorigenesis and tumor progression are associated with dysfunction of the nuclear transport machinery at the level of import and export receptors (karyopherins). Recent studies have shown that the nuclear import factor ... Integrity of mTORC2 is dependent on the rictor Gly-934 site [作者：Aimbetov, R; Chen, CH; Bulgakova, O; Abetov, D; Bissenbaev, AK; Bersimbaev, RI; Sarbassov, DD,期刊：Oncogene, 页码：2115-2120 , 文章类型： Article，,卷期：2012年31-16] Growth factor signaling coupled to activation of the phosphatidylinositol-3-OH kinase (PI3K)/Akt pathway plays a crucial role in the regulation of cell proliferation and survival. The key regulatory kinase of Akt has bee...