- Group III secreted phospholipase A(2) transgenic mice spontaneously develop inflammation
[作者:Sato, H; Taketomi, Y; Isogai, Y; Masuda, S; Kobayashi, T; Yamamoto, K; Murakami, M,期刊:Biochemical Journal, 页码:17-27 , 文章类型: Article,,卷期:2009年421-Part 1]
PLA(2) (phospholipase A(2)) group III is an atypical sPLA(2) (secretory PLA,) that is homologous with bee venom PLA(2) rather than with other mammalian sPLA(2)S. In the present paper, we show that endogenous group III...
- Ku-0063794 is a specific inhibitor of the mammalian target of rapamycin (mTOR)
[作者:Garcia-Martinez, JM; Moran, J; Clarke, RG; Gray, A; Cosulich, SC; Chresta, CM; Alessi, DR,期刊:Biochemical Journal, 页码:29-42 , 文章类型: Article,,卷期:2009年421-Part 1]
- mTOR (mammalian target of rapamycin) stimulates cell growth by phosphorylating and promoting activation of AGC (protein kinase A/protein kinase G/protein kinase Q family kinases such as Akt (protein kinase 13), S6K (p70 ...
- The catalytic mechanism of NADH-dependent reduction of 9,10-phenanthrenequinone by Candida tenuis xylose reductase reveals plasticity in an aldo-keto reductase active site
[作者:Pival, SL; Klimacek, M; Nidetzky, B,期刊:Biochemical Journal, 页码:43-49 , 文章类型: Article,,卷期:2009年421-Part 1]
Despite their widely varying physiological functions in carbonyl metabolism, AKR2B5 (Candida tenuis xylose reductase) and many related enzymes of the aldo-keto reductase protein superfamily utilise PQ (9,10-phenanthre...
- Mitochondrial peroxiredoxin 3 is more resilient to hyperoxidation than cytoplasmic peroxiredoxins
[作者:Cox, AG; Pearson, AG; Pullar, JM; Jonsson, TJ; Lowther, WT; Winterbourn, CC; Hampton, MB,期刊:Biochemical Journal, 页码:51-58 , 文章类型: Article,,卷期:2009年421-Part 1]
- The Prxs (peroxiredoxins) are a family of cysteine-dependent peroxidases that decompose hydrogen peroxide. Prxs become hyperoxidized when a sulfenic acid formed during the catalytic cycle reacts with hydrogen peroxide. I...
- Protein phosphatase 2A plays a role in hydrogen peroxide-induced disruption of tight junctions in Caco-2 cell monolayers
[作者:Sheth, P; Samak, G; Shull, JA; Seth, A; Rao, R,期刊:Biochemical Journal, 页码:59-70 , 文章类型: Article,,卷期:2009年421-Part 1]
- Evidence indicates that PP2A (protein phosphatase 2A) interacts with epithelial tight junctions and negatively regulates the integrity of the tight junction. In the present study, the role of PP2A in the hydrogen peroxid...
- Inhibition of myeloperoxidase-mediated hypochlorous acid production by nitroxides
[作者:Rees, MD; Bottle, SE; Fairfull-Smith, KE; Malle, E; Whitelock, JM; Davies, MJ,期刊:Biochemical Journal, 页码:79-86 , 文章类型: Article,,卷期:2009年421-Part 1]
- Tissue damage resulting from the extracellular production of HOCI (hypochlorous acid) by the MPO (myeloperoxidase)-hydrogen peroxide-chloride system of activated phagocytes is implicated as a key event in the progression...
- The presence of monoglucosylated N196-glycan is important for the structural stability of storage protein, arylphorin
[作者:Ryu, KS; Lee, JO; Kwon, TH; Choi, HH; Park, HS; Hwang, SK; Lee, ZW; Lee, KB; Han, YH; Choi, YS; Jeon, YH; Cheong, C; Kim, S,期刊:Biochemical Journal, 页码:87-96 , 文章类型: Article,,卷期:2009年421-Part 1]
- Although N-glycosylation has been known to increase the stability of glycoproteins, it is difficult to assess the structural importance of glycans in the stabilization of glycoproteins. APA (Antheraea pernyi arylphorin) ...
- Structure-activity analysis of aging and reactivation of human butyrylcholinesterase inhibited by analogues of tabun
[作者:Carletti, E; Aurbek, N; Gillon, E; Loiodice, M; Nicolet, Y; Fontecilla-Camps, JC; Masson, P; Thiermann, H; Nachon, F; Worek, F,期刊:Biochemical Journal, 页码:97-106 , 文章类型: Article,,卷期:2009年421-Part 1]
- hBChE [human BChE (butyrylcholinesterase)] naturally scavenges OPs (organophosphates). This bioscavenger is currently in Clinical Phase I for pretreatment of OP intoxication. Phosphylated ChEs (cholinesterases) can under...
- The extracellular domain of the TGF beta type II receptor regulates membrane raft partitioning
[作者:Luga, V; McLean, S; Le Roy, C; O'Connor-McCourt, M; Wrana, JL; Di Guglielmo, GM,期刊:Biochemical Journal, 页码:119-131 , 文章类型: Article,,卷期:2009年421-Part 1]
- Cell-surface TGF beta (transforming growth factor) receptors partition into membrane rafts and the caveolin-positive endocytic compartment by an unknown mechanism. In the present Study, we investigated the determinant in...
- Molecular basis of the inhibitor selectivity and insights into the feedback inhibition mechanism of citramalate synthase from Leptospira interrogans
[作者:Zhang, P; Ma, J; Zhang, ZL; Zha, MW; Xu, H; Zhao, GP; Ding, JP,期刊:Biochemical Journal, 页码:133-143 , 文章类型: Article,,卷期:2009年421-Part 1]
- LiCMS (Leptospira interrogans citramalate synthase) catalyses the first reaction of the isoleucine biosynthesis pathway in L. interrogans, the pathogen of leptospirosis. The catalytic reaction is regulated through feedba...
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