- Global mapping of Al, Cu, Fe, and Zn in-use stocks and in-ground resources
[作者:Rauch, JN,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:18920-18925 , 文章类型: Article,,卷期:2009年106-45]
- Human activity has become a significant geomorphic force in modern times, resulting in unprecedented movements of material around Earth. An essential constituent of this material movement, the major industrial metals alu...
- Poly[di(carboxylatophenoxy)phosphazene] is a potent adjuvant for intradermal immunization
[作者:Andrianov, AK; DeCollibus, DP; Gillis, HA; Kha, HH; Marin, A; Prausnitz, MR; Babiuk, LA; Townsend, H; Mutwiri, G,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:18936-18941 , 文章类型: Article,,卷期:2009年106-45]
- Intradermal immunization using microfabricated needles represents a potentially powerful technology, which can enhance immune responses and provide antigen sparing. Solid vaccine formulations, which can be coated onto mi...
- Allosteric control of catalysis by the F loop of RNA polymerase
[作者:Miropolskaya, N; Artsimovitch, I; Klimasauskas, S; Nikiforov, V; Kulbachinskiy, A,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:18942-18947 , 文章类型: Article,,卷期:2009年106-45]
- Bacterial RNA polymerases (RNAPs) undergo coordinated conformational changes during catalysis. In particular, concerted folding of the trigger loop and rearrangements of the bridge helix at the RNAP active center have be...
- LACTB is a filament-forming protein localized in mitochondria
[作者:Polianskyte, Z; Peitsaro, N; Dapkunas, A; Liobikas, J; Soliymani, R; Lalowski, M; Speer, O; Seitsonen, J; Butcher, S; Cereghetti, GM; Linder, MD; Merckel, M; Thompson, J; Eriksson, O,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:18960-18965 , 文章类型: Article,,卷期:2009年106-45]
- LACTB is a mammalian active-site serine protein that has evolved from a bacterial penicillin-binding protein. Penicillin-binding proteins are involved in the metabolism of peptidoglycan, the major bacterial cell wall con...
- Structure of the lethal phage pinhole
[作者:Pang, T; Savva, CG; Fleming, KG; Struck, DK; Young, R,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:18966-18971 , 文章类型: Article,,卷期:2009年106-45]
- Perhaps the simplest of biological timing systems, bacteriophage holins accumulate during the phage morphogenesis period and then trigger to permeabilize the cytoplasmic membrane with lethal holes; thus, terminating the ...
- Simultaneous prediction of protein folding and docking at high resolution
[作者:Das, R; Andre, I; Shen, Y; Wu, YB; Lemak, A; Bansal, S; Arrowsmith, CH; Szyperski, T; Baker, D,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:18978-18983 , 文章类型: Article,,卷期:2009年106-45]
- Interleaved dimers and higher order symmetric oligomers are ubiquitous in biology but present a challenge to de novo structure prediction methodology: The structure adopted by a monomer can be stabilized largely by inter...
- Ligand migration through the internal hydrophobic cavities in human neuroglobin
[作者:Abbruzzetti, S; Faggiano, S; Bruno, S; Spyrakis, F; Mozzarelli, A; Dewilde, S; Moens, L; Viappiani, C,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:18984-18989 , 文章类型: Article,,卷期:2009年106-45]
- Neuroglobin (Ngb), a member of the globin superfamily, was found in the brain of vertebrates and is suggested to play a neuroprotective function under hypoxic conditions by scavenging nitrogen monoxide ( NO) through a di...
- Molecular basis for insulin fibril assembly
[作者:Ivanova, MI; Sievers, SA; Sawaya, MR; Wall, JS; Eisenberg, D,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:18990-18995 , 文章类型: Article,,卷期:2009年106-45]
- In the rare medical condition termed injection amyloidosis, extracellular fibrils of insulin are observed. We found that the segment of the insulin B-chain with sequence LVEALYL is the smallest segment that both nucleate...
- Constructing the equilibrium ensemble of folding pathways from short off-equilibrium simulations
[作者:Noe, F; Schutte, C; Vanden-Eijnden, E; Reich, L; Weikl, TR,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:19011-19016 , 文章类型: Article,,卷期:2009年106-45]
- Characterizing the equilibrium ensemble of folding pathways, including their relative probability, is one of the major challenges in protein folding theory today. Although this information is in principle accessible via ...
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