- Embryonic origin and Hox status determine progenitor cell fate during adult bone regeneration
[作者:Leucht, P; Kim, JB; Amasha, R; James, AW; Girod, S; Helms, JA,期刊:Development, 页码:2845-2854 , 文章类型: Article,,卷期:2008年135-17]
- The fetal skeleton arises from neural crest and from mesoderm. Here, we provide evidence that each lineage contributes a unique stem cell population to the regeneration of injured adult bones. Using Wnt1Cre::Z/EG mice we...
- Rho inhibition recruits DCC to the neuronal plasma membrane and enhances axon chemoattraction to netrin 1
[作者:Moore, SW; Correia, JP; Sun, KLW; Pool, M; Fournier, AE; Kennedy, TE,期刊:Development, 页码:2855-2864 , 文章类型: Article,,卷期:2008年135-17]
- Molecular cues, such as netrin 1, guide axons by influencing growth cone motility. Rho GTPases are a family of intracellular proteins that regulate the cytoskeleton, substrate adhesion and vesicle trafficking. Activation...
- Dlx genes pattern mammalian jaw primordium by regulating both lower jaw-specific and upper jaw-specific genetic programs
[作者:Jeong, J; Li, X; McEvilly, RJ; Rosenfeld, MG; Lufkin, T; Rubenstein, JLR,期刊:Development, 页码:2905-2916 , 文章类型: Article,,卷期:2008年135-17]
- Dlx transcription factors are implicated in patterning the mammalian jaw, based on their nested expression patterns in the first branchial arch (primordium for jaw) and mutant phenotypes; inactivation of Dlx1 and Dlx2 (D...
- RNA polymerase II-mediated transcription at active loci does not require histone H3S10 phosphorylation in Drosophila
[作者:Cai, WL; Bao, XM; Deng, H; Jin, Y; Girton, J; Johansen, J; Johansen, KM,期刊:Development, 页码:2917-2925 , 文章类型: Article,,卷期:2008年135-17]
- JIL-1 is the major kinase controlling the phosphorylation state of histone H3S10 at interphase in Drosophila. In this study, we used three different commercially available histone H3S10 phosphorylation antibodies, as wel...
- Two highly related regulatory subunits of PP2A exert opposite effects on TGF-beta/Activin/Nodal signalling
[作者:Batut, J; Schmierer, B; Cao, J; Raftery, LA; Hill, CS; Howell, M,期刊:Development, 页码:2927-2937 , 文章类型: Article,,卷期:2008年135-17]
- We identify B alpha (PPP2R2A) and B delta (PPP2R2D), two highly related members of the B family of regulatory subunits of the protein phosphatase PP2A, as important modulators of TGF-beta/Activin/Nodal signalling that af...
- Cited2 is required for the proper formation of the hyaloid vasculature and for lens morphogenesis
[作者:Chen, Y; Doughman, YQ; Gu, S; Jarrell, A; Aota, SI; Cvekl, A; Watanabe, M; Dunwoodie, SL; Johnson, RS; van Heyningen, V; Kleinjan, DA; Beebe, DC; Yang, YC,期刊:Development, 页码:2939-2948 , 文章类型: Article,,卷期:2008年135-17]
- Cited2 is a transcriptional modulator with pivotal roles in different biological processes. Cited2-deficient mouse embryos manifested two major defects in the developing eye. An abnormal corneal-lenticular stalk was char...
- Abnormal sympathetic nervous system development and physiological dysautonomia in Egr3-deficient mice
[作者:Eldredge, LC; Gao, XM; Quach, DH; Li, L; Han, XQ; Lomasney, J; Tourtellotte, WG,期刊:Development, 页码:2949-2957 , 文章类型: Article,,卷期:2008年135-17]
- Sympathetic nervous system development depends upon many factors that mediate neuron migration, differentiation and survival. Target tissue-derived nerve growth factor (NGF) signaling-induced gene expression is required ...
- Defining early lineage specification of human embryonic stem cells by the orchestrated balance of canonical Wnt/beta-catenin, Activin/Nodal and BMP signaling
[作者:Sumi, T; Tsuneyoshi, N; Nakatsuji, N; Suemori, H,期刊:Development, 页码:2969-2979 , 文章类型: Article,,卷期:2008年135-17]
- The canonical Wnt/beta-catenin signaling has remarkably diverse roles in embryonic development, stem cell self-renewal and cancer progression. Here, we show that stabilized expression of beta-catenin perturbed human embr...
- SM22 alpha-targeted deletion of bone morphogenetic protein receptor 1A in mice impairs cardiac and vascular development, and influences organogenesis
[作者:El-Bizri, N; Guignabert, C; Wang, L; Cheng, A; Stankunas, K; Chang, CP; Mishina, Y; Rabinovitch, M,期刊:Development, 页码:2981-2991 , 文章类型: Article,,卷期:2008年135-17]
- Expression of bone morphogenetic protein receptor 1A (BMPR1A) is attenuated in the lung vessels of patients with pulmonary arterial hypertension, but the functional impact of this abnormality is unknown. We ablated Bmpr1...
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