- Preparation and in vivo imaging of PEG-poly(L-lysine)-based polymeric micelle MRI contrast agents
[作者:Shiraishi, K; Kawano, K; Minowa, T; Maitani, Y; Yokoyama, M,期刊:Journal of controlled release, 页码:14-20 , 文章类型: Article,,卷期:2009年136-1]
- A polymeric micelle drug carrier system was applied to the targeting of an MRI (magnetic resonance imaging) contrast agent. A block copolymer, PEG-b-poly(L-lysine), was used for conjugation of gadolinium ions through che...
- Novel irinotecan-loaded liposome using phytic acid with high therapeutic efficacy for colon tumors
[作者:Hattori, Y; Shi, L; Ding, WX; Koga, K; Kawano, K; Hakoshima, M; Maitani, Y,期刊:Journal of controlled release, 页码:30-37 , 文章类型: Article,,卷期:2009年136-1]
- Phytic acid (IP-6) is a polyphosphorylated carbohydrate with antitumor activity for many kinds of tumors. In this study, we developed a novel method of loading irinotecan (CPT-11) into liposomes using IP-6, and evaluated...
- Enhanced dissolution rate and synchronized release of drugs in binary systems through formulation: Amorphous naproxen-cimetidine mixtures prepared by mechanical activation
[作者:Alleso, M; Chieng, N; Rehder, S; Rantanen, J; Rades, T; Aaltonen, J,期刊:Journal of controlled release, 页码:45-53 , 文章类型: Article,,卷期:2009年136-1]
- Naproxen, a non-steroidal anti-inflammatory drug (NSAID), is a biopharmaceutics classification system (BCS) class 11 drug whose bioavailability is rate-limited by its dissolution. Cimetidine is sometimes co-administered ...
- Optimization and characterization of anionic lipoplexes for gene delivery
[作者:Srinivasan, C; Burgess, DJ,期刊:Journal of controlled release, 页码:62-70 , 文章类型: Article,,卷期:2009年136-1]
- Anionic lipoplexes, comprising divalent cations, DNA and anionic liposomes, were optimized for high transfection efficiency and low cytotoxicity. Different molar ratios of anionic to zwitterionic lipid, 1:9 to 1:1 (1,2-d...
- Microneedle arrays for the transcutaneous immunization of diphtheria and influenza in BALB/c mice
[作者:Ding, Z; Verbaan, FJ; Bivas-Benita, M; Bungener, L; Huckriede, A; van den Berg, DJ; Kersten, G; Bouwstra, JA,期刊:Journal of controlled release, 页码:71-78 , 文章类型: Article,,卷期:2009年136-1]
- Transcutaneous immunization (TCI) is limited by poor permeation of macromolecules across the skin. Microneedle arrays form transient conduits and enhance the transport of vaccine molecules across the skin barrier without...
- Enhanced antigen presentation and CTL activity by transduction of mature rather than immature dendritic cells with octaarginine-modified liposomes
[作者:Homhuan, A; Kogure, K; Nakamura, T; Shastri, N; Harashima, H,期刊:Journal of controlled release, 页码:79-85 , 文章类型: Article,,卷期:2009年136-1]
- To improve uptake and cross-presentation of exogenous antigens (Ag) by dendritic cells (DCs), octaarginine-modified liposomes (R8-Lip) were used as a novel strategy for protein-Ag transduction. Immature DCs endocytose ma...
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