- Surface engineering of microparticles by novel protein transfer for targeted antigen/drug delivery
[作者:Bumgarner, GW; Shashidharamurthy, R; Nagarajan, S; D'Souza, MJ; Selvaraj, P,期刊:Journal of controlled release, 页码:90-97 , 文章类型: Article,,卷期:2009年137-2]
- Biodegradable microparticles can function as an adjuvant by targeting antigens to professional antigen presenting cells such as dendritic cells and macrophages. To enhance targeting of microparticles, we have developed a...
- Prevention of pulmonary metastasis from subcutaneous tumors by binary system-based sustained delivery of catalase
[作者:Hyoudou, K; Nishikawa, M; Ikemura, M; Kobayashi, Y; Mendelsohn, A; Miyazaki, N; Tabata, Y; Yamashita, F; Hashida, M,期刊:Journal of controlled release, 页码:110-115 , 文章类型: Article,,卷期:2009年137-2]
- Catalase delivery can be effective in inhibiting reactive oxygen species (ROS)-mediated acceleration of tumor metastasis. Our previous studies have demonstrated that increasing the plasma half-life of catalase by pegylat...
- Enhanced antiviral activity of Acyclovir loaded into beta-cyclodextrin-poly(4-acryloylmorpholine) conjugate nanoparticles
[作者:Cavalli, R; Donalisio, M; Civra, A; Ferruti, P; Ranucci, E; Trotta, F; Lembo, D,期刊:Journal of controlled release, 页码:116-122 , 文章类型: Article,,卷期:2009年137-2]
- Novel polymeric nanoparticles based on a beta-cyclodextrin-poly(4-acryloylmorpholine) mono-conjugate (beta-CD-PACM), a tadpole-shaped polymer in which the beta-CD ring is the hydrophilic head and the PACM chain the amphi...
- Penetration and efficacy of VEGF siRNA using polyelectrolyte complex micelles in a human solid tumor model in-vitro
[作者:Al-Abd, AM; Lee, SH; Kim, SH; Cha, JH; Park, TG; Lee, SJ; Kuh, HJ,期刊:Journal of controlled release, 页码:130-135 , 文章类型: Article,,卷期:2009年137-2]
- A polyelectrolyte complex(PEC) micelle-based siRNAdelivery system has been developed for vascular endothelial growth factor (VEGF),and its antitumor efficacy has been demonstrated using in-vivo animal models. Penetration...
- Dynamics of magnetic lipoplexes studied by single particle tracking in living cells
[作者:Sauer, AM; de Bruin, KG; Ruthardt, N; Mykhaylyk, O; Plank, C; Brauchle, C,期刊:Journal of controlled release, 页码:136-145 , 文章类型: Article,,卷期:2009年137-2]
- Magnetofection, gene delivery under the influence of a magnetic field, is a technique to increase transfection efficiency by enforcing gene vector contact with a target cell. Mechanisms of magnetic lipoplex internalizati...
- Extracellular matrix binding mixed micelles for drug delivery applications
[作者:O'Neil, CP; van der Vlies, AJ; Velluto, D; Wandrey, C; Demurtas, D; Dubochet, J; Hubbell, JA,期刊:Journal of controlled release, 页码:146-151 , 文章类型: Article,,卷期:2009年137-2]
- We present the formation of collagen-binding mixed micelles and their potential suitability to deliver therapeutic drugs to the vessel wall. We modified poly(ethylene oxide)-bl-poly (propylene oxide)-bipoly(ethylene oxid...
- Development of a sustained-release recombinant human growth hormone formulation
[作者:Kwak, HH; Shim, WS; Choi, MK; Son, MK; Kim, YJ; Yang, HC; Kim, TH; Lee, GI; Kim, BM; Kang, SH; Shim, CK,期刊:Journal of controlled release, 页码:160-165 , 文章类型: Article,,卷期:2009年137-2]
- Recombinant human growth hormone (rhGH) therapy for short stature must be administered as a daily injection because of its poor bioavailability and short half-life. In the present study, a sustained-release formulation o...
- In vivo delivery of a peptide, ghrelin antagonist, with mesoporous silicon microparticles
[作者:Kilpelainen, M; Riikonen, J; Vlasova, MA; Huotari, A; Lehto, VP; Salonen, J; Herzig, KH; Jarvinen, K,期刊:Journal of controlled release, 页码:166-170 , 文章类型: Article,,卷期:2009年137-2]
- Pepticles may represent potential treatment options for many severe illnesses. However, they need an effective delivery system to overcome rapid degradation after their administration. One possible way to prolong peptide...
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