- Inactivation of the putative suppressor gene DOK1 by promoter hypermethylation in primary human cancers
[作者:Saulnier, A; Vaissiere, T; Yue, JP; Siouda, M; Malfroy, M; Accardi, R; Creveaux, M; Sebastian, S; Shahzad, N; Gheit, T; Hussain, I; Torrente, M; Maffini, FA; Calabrese, L; Chiesa, F; Cuenin, C; Shukla, R; Fathallah, I; Matos, E; Daudt, A; Koifman, S; Wuensch, V; Menezes, AMB; Curado, MP; Zaridze, D; Boffetta, P; Brennan, P; Tommasino, M; Herceg, Z; Sylla, BS,期刊:International Journal of Cancer, 页码:2484-2494 , 文章类型: Article,,卷期:2012年130-11]
- The DOK1 gene is a putative tumour suppressor gene located on the human chromosome 2p13 which is frequently rearranged in leukaemia and other human tumours. We previously reported that the DOK1 gene can be mutated and it...
- Role of BRCA1 in controlling mitotic arrest in ovarian cystadenoma cells
[作者:Yu, VM; Marion, CM; Austria, TM; Yeh, J; Schonthal, AH; Dubeau, L,期刊:International Journal of Cancer, 页码:2495-2504 , 文章类型: Article,,卷期:2012年130-11]
- Cancers that develop in BRCA1 mutation carriers are usually near tetraploid/polyploid. This led us to hypothesize that BRCA1 controls the mitotic checkpoint complex, as loss of such control could lead to mitotic errors r...
- PI3K class IB controls the cell cycle checkpoint promoting cell proliferation in hepatocellular carcinoma
[作者:Dituri, F; Mazzocca, A; Lupo, L; Edling, CE; Azzariti, A; Antonaci, S; Falasca, M; Giannelli, G,期刊:International Journal of Cancer, 页码:2505-2513 , 文章类型: Article,,卷期:2012年130-11]
- Alterations of the cell cycle checkpoint frequently occur during hepatocarcinogenesis. Dysregulation of the phosphatidylinositol-3-kinases (PI3K) signaling pathway is believed to exert a potential oncogenic effect in hep...
- Calpain-6 is an endothelin-1 signaling dependent protective factor in chemoresistant osteosarcoma
[作者:Marion, A; Dieudonne, FX; Patino-Garcia, A; Lecanda, F; Marie, PJ; Modrowski, D,期刊:International Journal of Cancer, 页码:2514-2525 , 文章类型: Article,,卷期:2012年130-11]
- Bone tumors strongly influence normal tissues and stimulate bone cells for the production of cytokines supporting proliferation and abnormal survival in cancer cells. We previously reported that the proteoglycan syndecan...
- Phosphorylation of vasodilator-stimulated phosphoprotein Ser239 suppresses filopodia and invadopodia in colon cancer
[作者:Zuzga, DS; Pelta-Heller, J; Li, P; Bombonati, A; Waldman, SA; Pitari, GM,期刊:International Journal of Cancer, 页码:2539-2548 , 文章类型: Article,,卷期:2012年130-11]
- In colorectal cancer, the antitumorigenic guanylyl cyclase C (GCC) signalome is defective reflecting ligand deprivation from downregulation of endogenous hormone expression. Although the proximal intracellular mediators ...
- Downregulation and growth inhibitory role of FHL1 in lung cancer
[作者:Niu, C; Liang, CY; Guo, JT; Cheng, L; Zhang, H; Qin, X; Zhang, QW; Ding, LH; Yuan, B; Xu, XJ; Li, JZ; Lin, J; Ye, QN,期刊:International Journal of Cancer, 页码:2549-2556 , 文章类型: Article,,卷期:2012年130-11]
- Four and a half Lin-11, Isl-1, Mac-3 (LIM) protein 1 (FHL1) has been linked to carcinogenesis. However, the role of FHL1 in lung cancer remains unclear and the detailed mechanism underlying its tumor suppressive role is ...
- 3-Deazaneplanocin A is a promising therapeutic agent for the eradication of tumor-initiating hepatocellular carcinoma cells
[作者:Chiba, T; Suzuki, E; Negishi, M; Saraya, A; Miyagi, S; Konuma, T; Tanaka, S; Tada, M; Kanai, F; Imazeki, F; Iwama, A; Yokosuka, O,期刊:International Journal of Cancer, 页码:2557-2567 , 文章类型: Article,,卷期:2012年130-11]
- Recent advances in stem cell biology have identified tumor-initiating cells (TICs) in a variety of cancers including hepatocellular carcinoma (HCC). Polycomb group gene products such as BMI1 and EZH2 have been characteri...
- Loss of p16 expression is associated with the stem cell characteristics of surface markers and therapeutic resistance in estrogen receptor-negative breast cancer
[作者:Arima, Y; Hayashi, N; Hayashi, H; Sasaki, M; Kai, K; Sugihara, E; Abe, E; Yoshida, A; Mikami, S; Nakamura, S; Saya, H,期刊:International Journal of Cancer, 页码:2568-2579 , 文章类型: Article,,卷期:2012年130-11]
- Triple-negative breast cancer [TNBC, which is negative for the estrogen receptor (ER), progesterone receptor, and human epidermal growth factor receptor 2] is a high-risk form of the disease without a specific therapy. D...
- Genome structure-based screening identified epigenetically silenced microRNA associated with invasiveness in non-small-cell lung cancer
[作者:Watanabe, K; Emoto, N; Hamano, E; Sunohara, M; Kawakami, M; Kage, H; Kitano, K; Nakajima, J; Goto, A; Fukayama, M; Nagase, T; Yatomi, Y; Ohishi, N; Takai, D,期刊:International Journal of Cancer, 页码:2580-2590 , 文章类型: Article,,卷期:2012年130-11]
- MicroRNA (miRNA) expression is frequently altered in human cancers. To search for epigenetically silenced miRNAs in non-small-cell lung cancer (NSCLC), we mapped human miRNAs on autosomal chromosomes and selected 55 miRN...
- Dickkopf-3 is regulated by the MYCN-induced miR-17-92 cluster in neuroblastoma
[作者:De Brouwer, S; Mestdagh, P; Lambertz, I; Pattyn, F; De Paepe, A; Westermann, F; Schroeder, C; Schulte, JH; Schramm, A; De Preter, K; Vandesompele, J; Speleman, F,期刊:International Journal of Cancer, 页码:2591-2598 , 文章类型: Article,,卷期:2012年130-11]
- Neuroblastoma (NB) is a paediatric tumour with a remarkable diverse clinical behaviour. Approximately half of the high stage aggressive tumours are characterized by MYCN gene amplification but our understanding of the ro...
- Identification of a novel recurrent 1q42.2-1qter deletion in high risk MYCN single copy 11q deleted neuroblastomas
[作者:Fieuw, A; Kumps, C; Schramm, A; Pattyn, F; Menten, B; Antonacci, F; Sudmant, P; Schulte, JH; Van Roy, N; Vergult, S; Buckley, PG; De Paepe, A; Noguera, R; Versteeg, R; Stallings, R; Eggert, A; Vandesompele, J; De Preter, K; Speleman, F,期刊:International Journal of Cancer, 页码:2599-2606 , 文章类型: Article,,卷期:2012年130-11]
- Neuroblastoma is an aggressive embryonal tumor that accounts for similar to 15% of childhood cancer deaths. Hitherto, despite the availability of comprehensive genomic data on DNA copy number changes in neuroblastoma, re...
- Vaccination-induced functional competence of circulating human tumor-specific CD8 T-cells
[作者:Baumgaertner, P; Jandus, C; Rivals, JP; Derre, L; Lovgren, T; Baitsch, L; Guillaume, P; Luescher, IF; Berthod, G; Matter, M; Rufer, N; Michielin, O; Speiser, DE,期刊:International Journal of Cancer, 页码:2607-2617 , 文章类型: Article,,卷期:2012年130-11]
- T-cells specific for foreign (e.g., viral) antigens can give rise to strong protective immune responses, whereas self/tumor antigen-specific T-cells are thought to be less powerful. However, synthetic T-cell vaccines com...
- Administration of 6-gingerol greatly enhances the number of tumor-infiltrating lymphocytes in murine tumors
[作者:Ju, SA; Park, SM; Lee, YS; Bae, JH; Yu, R; An, WG; Suh, JH; Kim, BS,期刊:International Journal of Cancer, 页码:2618-2628 , 文章类型: Article,,卷期:2012年130-11]
- Tumor-infiltrating lymphocytes (TILs) play critical roles in host antitumor immune responses. It is known that cancer patients with tumor-reactive lymphocyte infiltration in their tumors have better prognoses, while pati...
- The emerging epidemic of estrogen-related cancers in young women in a developing Asian country
[作者:Lin, CH; Chen, YC; Chiang, CJ; Lu, YS; Kuo, KT; Huang, CS; Cheng, WF; Lai, MS; You, SL; Cheng, AL,期刊:International Journal of Cancer, 页码:2629-2637 , 文章类型: Article,,卷期:2012年130-11]
- The incidence of breast and genital tract cancers is increasing among Taiwanese women, but the age specificity and histopathological features of these cancers have not been determined. We used a descriptive epidemiologic...
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