- Bone induction by biomimetic PLGA-(PEG-ASP)n copolymer loaded with a novel synthetic BMP-2-related peptide in vitro and in vivo
[作者:Lin, ZY; Duan, ZX; Guo, XD; Li, JF; Lu, HW; Zheng, QX; Quan, DP; Yang, SH,期刊:Journal of controlled release, 页码:190-195 , 文章类型: Article,,卷期:2010年144-2]
- BMP-2 is one of the most important growth factors of bone regeneration. Polylactide-co-glycolic acid (PLGA), which is used as a biodegradable scaffold for delivering therapeutic agents, has been intensively investigated....
- A nanoparticulate system that enhances the efficacy of the tumoricide Dz13 when administered proximal to the lesion site
[作者:Tan, ML; Dunstan, DE; Friedhuber, AM; Choong, PFM; Dass, CR,期刊:Journal of controlled release, 页码:196-202 , 文章类型: Article,,卷期:2010年144-2]
- We demonstrate that Dz13, a DNA enzyme that cleaves c-Jun mRNA, and is capable of inhibiting cancer cell growth in vitro, can be encapsulated into chitosan nanoparticles. For optimisation of this chitosan-based formulati...
- Optimized pulmonary gene transfection in mice by spray-freeze dried powder inhalation
[作者:Mohri, K; Okuda, T; Mori, A; Danjo, K; Okamoto, H,期刊:Journal of controlled release, 页码:221-226 , 文章类型: Article,,卷期:2010年144-2]
- Spray-freeze drying (SFD) is an attractive technique to prepare highly porous dry powders for inhalation. However, there have been few reports of its application to dry powder inhalers (DPIs). Therefore, in this study, w...
- Lipophilic siRNAs mediate efficient gene silencing in oligodendrocytes with direct CNS delivery
[作者:Chen, QM; Butler, D; Querbes, W; Pandey, RK; Ge, P; Maier, MA; Zhang, LG; Rajeev, KG; Nechev, L; Kotelianski, V; Manoharan, M; Sah, DWY,期刊:Journal of controlled release, 页码:227-232 , 文章类型: Article,,卷期:2010年144-2]
- Conjugation of small interfering RNA (siRNA) with lipophilic molecules has been demonstrated to enhance cellular uptake in cell culture and to produce efficient endogenous gene silencing in the liver after systemic admin...
- Formulation, characterization and pulmonary deposition of nebulized celecoxib encapsulated nanostructured lipid carriers
[作者:Patlolla, RR; Chougule, M; Patel, AR; Jackson, T; Tata, PNV; Singh, M,期刊:Journal of controlled release, 页码:233-241 , 文章类型: Article,,卷期:2010年144-2]
- The aim of the current study was to encapsulate celecoxib (Cxb) in the nanostructured lipid carrier (Cxb-NLC) nanoparticles and evaluate the lung disposition of nanoparticles following nebulization in Balb/c mice. Cxb-NL...
- Chitosan-based nanogels for selective delivery of photosensitizers to macrophages and improved retention in and therapy of articular joints
[作者:Schmitt, F; Lagopoulos, L; Kauper, P; Rossi, N; Busso, N; Barge, J; Wagnieres, G; Laue, C; Wandrey, C; Juillerat-Jeanneret, L,期刊:Journal of controlled release, 页码:242-250 , 文章类型: Article,,卷期:2010年144-2]
- Macrophages play key roles in inflammatory disorders. Therefore, they are targets of treatments aiming at their local destruction in inflammation sites. However, injection of low molecular mass therapeutics, including ph...
- Targeted delivery of SiRNA to CD33-positive tumor cells with liposomal carrier systems
[作者:Rothdiener, M; Muller, D; Castro, PG; Scholz, A; Schwemmlein, M; Fey, G; Heidenreich, O; Kontermann, RE,期刊:Journal of controlled release, 页码:251-258 , 文章类型: Article,,卷期:2010年144-2]
- SiRNA molecules represent promising therapeutic molecules, e.g. for cancer therapy. However, efficient delivery into tumor cells remains a major obstacle for treatment. Here, we describe a liposomal siRNA carrier system ...
- Tumoral acidic pH-responsive MPEG-poly(beta-amino ester) polymeric micelles for cancer targeting therapy
[作者:Min, KH; Kim, JH; Bae, SM; Shin, H; Kim, MS; Park, S; Lee, H; Park, RW; Kim, IS; Kim, K; Kwon, IC; Jeong, SY; Lee, DS,期刊:Journal of controlled release, 页码:259-266 , 文章类型: Article,,卷期:2010年144-2]
- Herein, we evaluated the tumoral low pH targeting characteristics of pH-responsive polymer micelles in cancer targeting therapy. To design the pH-responsive polymeric micelles, hydrophilic methyl ether poly (ethylene gly...
- Targeted PLGA nano- but not microparticles specifically deliver antigen to human dendritic cells via DC-SIGN in vitro
[作者:Cruz, LJ; Tacken, PJ; Fokkink, R; Joosten, B; Stuart, MC; Albericio, F; Torensma, R; Figdor, CG,期刊:Journal of controlled release, 页码:118-126 , 文章类型: Article,,卷期:2010年144-2]
- Vaccine efficacy is strongly enhanced by antibody-mediated targeting of vaccine components to dendritic cells (DCs), which are professional antigen presenting cells. However, the options to link antigens or immune modula...
- A comparison between spray drying and spray freeze drying to produce an influenza subunit vaccine powder for inhalation
[作者:Saluja, V; Amorij, JP; Kapteyn, JC; de Boer, AH; Frijlink, HW; Hinrichs, WLJ,期刊:Journal of controlled release, 页码:127-133 , 文章类型: Article,,卷期:2010年144-2]
- The aim of this study was to investigate two different processes to produce a stable influenza subunit vaccine powder for pulmonary immunization i.e. spray drying (SD) and spray freeze drying (SFD). The formulations were...
- Tumor-homing glycol chitosan/polyethylenimine nanoparticles for the systemic delivery of siRNA in tumor-bearing mice
[作者:Huh, MS; Lee, SY; Park, S; Lee, S; Chung, H; Lee, S; Choi, Y; Oh, YK; Park, JH; Jeong, SY; Choi, K; Kim, K; Kwon, IC,期刊:Journal of controlled release, 页码:134-143 , 文章类型: Article,,卷期:2010年144-2]
- Here, we designed a new nano-sized siRNA carrier system composed of biocompatible/biodegradable glycol chitosan polymer (GC) and strongly positively charged polyethylenimine (PEI) polymers. In order to make a stable and ...
- Gemcitabine-loaded PEGylated unilamellar liposomes vs GEMZAR (R): Biodistribution, pharmacokinetic features and in vivo antitumor activity
[作者:Paolino, D; Cosco, D; Racanicchi, L; Trapasso, E; Celia, C; Iannone, M; Puxeddu, E; Costante, G; Filetti, S; Russo, D; Fresta, M,期刊:Journal of controlled release, 页码:144-150 , 文章类型: Article,,卷期:2010年144-2]
- The systemic efficacy of the chemotherapeutic agents presently used to treat solid tumors is limited by their low therapeutic index. Previously, our research group improved the in vitro antitumoral activity of gemcitabin...
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