- Injectable intratumoral depot of thermally responsive polypeptide-radionuclide conjugates delays tumor progression in a mouse model
[作者:Liu, WG; MacKay, JA; Dreher, MR; Chen, MN; McDaniel, JR; Simnick, AJ; Callahan, DJ; Zalutsky, MR; Chilkoti, A,期刊:Journal of controlled release, 页码:2-9 , 文章类型: Article,,卷期:2010年144-1]
- This study evaluated a biodegradable drug delivery system for local cancer radiotherapy consisting of a thermally sensitive elastin-like polypeptide (ELP) conjugated to a therapeutic radionuclide. Two ELPs (49 kDa) were ...
- The fatty acid conjugated exendin-4 analogs for type 2 antidiabetic therapeutics
[作者:Chae, SY; Choi, YG; Son, S; Jung, SY; Lee, DS; Lee, KC,期刊:Journal of controlled release, 页码:10-16 , 文章类型: Article,,卷期:2010年144-1]
- Improved glucagon-like peptide-1 (GLP-1) receptor activation is considered one of the most effective targets for antidiabetic therapy. For this purpose, we modified the GLP-1 analog of exendin-4 using two fatty acids (FA...
- Role of trimethylated chitosan (TMC) in nasal residence time, local distribution and toxicity of an intranasal influenza vaccine
[作者:Hagenaars, N; Mania, M; de Jong, P; Que, I; Nieuwland, R; Slutter, B; Glansbeek, H; Heldens, J; van den Bosch, H; Lowik, C; Kaijzel, E; Mastrobattista, E; Jiskoot, W,期刊:Journal of controlled release, 页码:17-24 , 文章类型: Article,,卷期:2010年144-1]
- The nose is a promising immunization site and intranasal (in.) vaccination studies with whole inactivated influenza virus (WIV) adjuvanted with N,N,N-trimethylchitosan (TMC-WIV) have shown promising results. In this stud...
- Synthesis, characterization, mucoadhesion and biocompatibility of thiolated carboxymethyl dextran-cysteine conjugate
[作者:Shahnaz, G; Perera, G; Sakloetsakun, D; Rahmat, D; Bernkop-Schnurch, A,期刊:Journal of controlled release, 页码:32-38 , 文章类型: Article,,卷期:2010年144-1]
- This study was aimed at improving the mucoadhesive properties of carboxymethyl dextran by the covalent attachment of cysteine. Mediated by a carbodiimide, L-cysteine was covalently attached to the polymer. The resulting ...
- Thiolated trimethyl chitosan nanocomplexes as gene carriers with high in vitro and in vivo transfection efficiency
[作者:Zhao, X; Yin, LC; Ding, JY; Tang, C; Gu, SH; Yin, CH; Mao, YM,期刊:Journal of controlled release, 页码:46-54 , 文章类型: Article,,卷期:2010年144-1]
- Trimethyl chitosan-cysteine conjugate (TMC-Cys) was evaluated as non-viral gene carriers to combine the advantages of TMC and thiolated chitosan. TMC-Cys with various molecular weights (30, 100, and 200 kDa) and quaterni...
- Functionalization of poly(amidoamine) dendrimers with hydrophobic chains for improved gene delivery in mesenchymal stem cells
[作者:Santos, JL; Oliveira, H; Pandita, D; Rodrigues, J; Pego, AP; Granja, PL; Tomas, H,期刊:Journal of controlled release, 页码:55-64 , 文章类型: Article,,卷期:2010年144-1]
- A new family of gene delivery vectors is synthesized consisting of a medium-size generation PAMAM dendrimer (generation 5, with amine termini) core randomly linked at the periphery to hydrophobic chains that vary in leng...
- Efficient delivery of intact phosphodiester oligonucleotides by poly-beta-amino esters
[作者:Remaut, K; Symens, N; Lucas, B; Demeester, J; De Smedt, SC,期刊:Journal of controlled release, 页码:65-74 , 文章类型: Article,,卷期:2010年144-1]
- Due to their great instability, phosphodiester antisense oligonucleotides (PO-ODNs) are rapidly degraded in the intracellular environment, which limits their biological activity. The release of PO-ODNs during a prolonged...
- Pegylated immuno-lipopolyplexes: A novel non-viral gene delivery system for liver cancer therapy
[作者:Hu, YR; Li, K; Wang, L; Yin, SS; Zhang, ZZ; Zhang, Y,期刊:Journal of controlled release, 页码:75-81 , 文章类型: Article,,卷期:2010年144-1]
- In this study, pegylated immuno-lipopolyplexes (PILP), a novel and efficient gene delivery system was developed by employing DNA/polyethylenimine (PEI 25 kDa) polyplexes, as well as anionic liposomes composed of POPC, (D...
- Specific down regulation of 3T3-L1 adipocyte differentiation by cell-permeable antisense HIF1 alpha-oligonucleotide
[作者:Park, YS; Huang, Y; Park, YJ; David, AE; White, L; He, HN; Chung, HS; Yang, VC,期刊:Journal of controlled release, 页码:82-90 , 文章类型: Article,,卷期:2010年144-1]
- Hypoxia is a strong modulator of angiogenesis, accelerating adipose tissue expansion, suggesting that hypoxia inducible factor la (HIF1 alpha.) can be a novel target for anti-obesity. We conjugated antisense-HIF1 alpha-o...
- Flow-through electroporation based on constant voltage for large-volume transfection of cells
[作者:Geng, T; Zhan, YH; Wang, HY; Witting, SR; Cornetta, KG; Lu, C,期刊:Journal of controlled release, 页码:91-100 , 文章类型: Article,,卷期:2010年144-1]
- Genetic modification of cells is a critical step involved in many cell therapy and gene therapy protocols. In these applications, cell samples of large volume (10(8)-10(9) cells) are often processed for transfection. Thi...
- Use of glycol chitosan modified by 5 beta-cholanic acid nanoparticles for the sustained release of proteins during murine embryonic limb skeletogenesis
[作者:Li, TS; Longobardi, L; Granero-Molto, F; Myers, TJ; Yan, Y; Spagnoli, A,期刊:Journal of controlled release, 页码:101-108 , 文章类型: Article,,卷期:2010年144-1]
- Murine embryonic limb cultures have invaluable roles in studying skeletogenesis. Substance delivery is an underdeveloped area in developmental biology that has primarily relied on Affi-Gel-Blue-agarose-beads. However, th...
- A novel strategy to tag matrix metalloproteinases-positive cells for in vivo imaging of invasive and metastatic activity of tumor cells
[作者:Zhao, T; Harada, H; Teramura, Y; Tanaka, S; Itasaka, S; Morinibu, A; Shinomiya, K; Zhu, YX; Hanaoka, H; Iwata, H; Saji, H; Hiraoka, M,期刊:Journal of controlled release, 页码:109-114 , 文章类型: Article,,卷期:2010年144-1]
- Matrix metalloproteinases (MMPs) are endopeptidases responsible for degrading the extracellular matrix (ECM) and remodeling tissue in both physiological and pathological processes. MMP2 and membrane-type 1 MMP (MT1-MMP) ...
|