- A new class of beta-carboline alkaloid-peptide conjugates with therapeutic efficacy in acute limb ischemia/reperfusion injury
[作者:Bi, W; Bi, Y; Xue, P; Zhang, YR; Gao, X; Wang, ZB; Li, M; Baudy-Floc'h, M; Ngerebara, N; Gibson, KM; Bi, LR,期刊:European Journal of Medicinal Chemistry, 页码:1453-1462 , 文章类型: Article,,卷期:2011年46-5]
- We describe a novel class of beta-carboline alkaloid-peptide conjugates that possess both free radical scavenging and thrombolytic activity. These conjugates demonstrate therapeutic efficacy in a rat arterial thrombosis ...
- Design, synthesis and antifungal activities of novel pyrrole alkaloid analogs
[作者:Wang, MZ; Xu, H; Liu, TW; Feng, Q; Yu, SJ; Wang, SH; Li, ZM,期刊:European Journal of Medicinal Chemistry, 页码:1463-1472 , 文章类型: Article,,卷期:2011年46-5]
- A series of novel analogs of pyrrole alkaloid were designed and synthesized by a facile method and their structures were characterized by H-1 NMR, C-13 NMR and high-resolution mass spectrometry (HRMS). The structure of c...
- Pyridine-derived thiosemicarbazones and their tin(IV) complexes with antifungal activity against Candida spp.
[作者:Parrilha, GL; da Silva, JG; Gouveia, LF; Gasparoto, AK; Dias, RP; Rocha, WR; Santos, DA; Speziali, NL; Beraldo, H,期刊:European Journal of Medicinal Chemistry, 页码:1473-1482 , 文章类型: Article,,卷期:2011年46-5]
- [(n-Bu)Sn(2Ac4oClPh)Cl-2] (1), [(n-Bu)Sn(2Ac4oFPh)Cl-2] (2), [(n-Bu)Sn(2Ac4oNO(2)Ph)Cl-2] (3), [(n-Bu)Sn (2Bz4oClPh)Cl-2] (4), [(n-Bu)Sn(2Bz4oFPh)Cl-2] (5) and [(n-Bu)Sn(2Bz4oNO(2)Ph)Cl-2] (6) were obtained by reacting [...
- Synthesis of some novel benzofuran-2-yl(4,5-dihyro-3,5-substituted diphenylpyrazol-1-yl) methanones and studies on the antiproliferative effects and reversal of multidrug resistance of human MDR1-gene transfected mouse lymphoma cells in vitro
[作者:Parekh, S; Bhavsar, D; Savant, M; Thakrar, S; Bavishi, A; Parmar, M; Vala, H; Radadiya, A; Pandya, N; Serly, J; Molnar, J; Shah, A,期刊:European Journal of Medicinal Chemistry, 页码:1942-1948 , 文章类型: Article,,卷期:2011年46-5]
- A new series of benzofuran-2-yl(4,5-diydro-3,5-substituted diphenylpyrazol-1-yl) methanone derivatives 8a-x by the reaction of the benzofuran-2-carbohydrazides 7 with various chalcone derivatives 3a-x using microwave irr...
- Synthesis and biological activity of novel N-6-substituted and 2,N-6-disubstituted adenine ribo- and 3 '-C-methyl-ribonucleosides as antitumor agents
[作者:Cappellacci, L; Petrelli, R; Franchetti, P; Vita, P; Kusumanchi, P; Kumar, M; Jayaram, HN; Zhou, BS; Yen, Y; Grifantini, M,期刊:European Journal of Medicinal Chemistry, 页码:1499-1504 , 文章类型: Article,,卷期:2011年46-5]
- A series of N-6-aminopurine-9-beta-D-ribonucleosides and ribose-modified 3'-C-methyl analogues substituted at N-6-position with a small group like hydroxy, methoxy or amino group or at C2(N-6) position have been synthesi...
- Synthesis, antimicrobial, antioxidant, anti-hemolytic and cytotoxic evaluation of new imidazole-based heterocycles
[作者:Abdel-Wahab, BF; Awad, GEA; Badria, FA,期刊:European Journal of Medicinal Chemistry, 页码:1505-1511 , 文章类型: Article,,卷期:2011年46-5]
- In the present work, 1-(5-methyl-2-phenyl-1H-imidazol-4-yl)ethanone 1 was prepared and used as a precursor for the synthesis of new thiazole, arylidiene and coumarin derivatives. The antimicrobial, antioxidant, anti-hemo...
- Discovery of novel SERCA inhibitors by virtual screening of a large compound library
[作者:Elam, C; Lape, M; Deye, J; Zultowsky, J; Stanton, DT; Paula, S,期刊:European Journal of Medicinal Chemistry, 页码:1512-1523 , 文章类型: Article,,卷期:2011年46-5]
- Two screening protocols based on recursive partitioning and computational ligand docking methodologies, respectively, were employed for virtual screens of a compound library with 345,000 entries for novel inhibitors of t...
- 1-Aryl-4-nitro-1H-imidazoles, a new promising series for the treatment of human African trypanosomiasis
[作者:Trunz, BB; Jedrysiak, R; Tweats, D; Brun, R; Kaiser, M; Suwinski, J; Torreele, E,期刊:European Journal of Medicinal Chemistry, 页码:1524-1535 , 文章类型: Article,,卷期:2011年46-5]
- Nitroimidazoles are a well-known class of antibacterial and antiprotozoal drugs but in spite of the widespread clinical and veterinary use of these drugs, this family has been stigmatized in part due to associated genoto...
- Design and synthesis of potent and selective aldose reductase inhibitors based on pyridylthiadiazine scaffold
[作者:Chen, X; Yang, YC; Ma, B; Zhang, SZ; He, ML; Gui, DQ; Hussain, S; Jing, CJ; Zhu, CJ; Yu, Q; Liu, Y,期刊:European Journal of Medicinal Chemistry, 页码:1536-1544 , 文章类型: Article,,卷期:2011年46-5]
- A series of pyrido[2,3-e]-[1,2,4]-thiadiazine 1,1-dioxide acetic acid derivatives were synthesized and tested for their inhibitory activity against aldose reductase (ALR2). These derivatives were found to be potent aldos...
- Synthesis of novel mast cell-stabilising and anti-allergic 1,2,3,4-tetrahydro-1-naphthalenols and related compounds
[作者:Barlow, JW; McHugh, AP; Woods, O; Walsh, JJ,期刊:European Journal of Medicinal Chemistry, 页码:1545-1554 , 文章类型: Article,,卷期:2011年46-5]
- In a continuation of our studies into indan and tetralin systems as novel modulators of allergic and inflammatory phenomena, we have extended our work to include dimers linked via C-C bonds. Of these compounds, 2-Benzyl-...
- Synthesis, characterization, antiproliferative and anti-metastatic properties of two ruthenium-DMSO complexes containing 2,2 '-biimidazole
[作者:Tan, CP; Hu, S; Liu, J; Ji, LN,期刊:European Journal of Medicinal Chemistry, 页码:1555-1563 , 文章类型: Article,,卷期:2011年46-5]
- Two new ruthenium complexes, trans,cis,cis-[RuCl2(DMSO)(2)(H(2)biim)] (1) and mer-[RuCl3(DMSO) (H(2)biim)] (2) (DMSO = dimethyl sulfoxide and H(2)biim = 2,2'-biimidazole), have been synthesized and fully characterized by...
- Synthesis, antibacterial and antimycobacterial activities of some new 4-aryl/heteroaryl-2,6-dimethyl-3,5-bis-N-(aryl)-carbamoyl-1,4-dihydropyridines
[作者:Sirisha, K; Bikshapathi, D; Achaiah, G; Reddy, VM,期刊:European Journal of Medicinal Chemistry, 页码:1564-1571 , 文章类型: Article,,卷期:2011年46-5]
- A novel class of 4-aryl/heteroaryl-2,6-dimethyl-3,5-bis-N-(phenyl/substituted phenyl)-carbamoyl-1,4-dihydropyridines has been synthesized by simple, economical and eco-friendly, modified Hantzsch condensation reaction ma...
- Syntheses and characterization of novel oxoisoaporphine derivatives as dual inhibitors for cholinesterases and amyloid beta aggregation
[作者:Li, YP; Ning, FX; Yang, MB; Li, YC; Nie, MH; Ou, TM; Tan, JH; Huang, SL; Li, D; Gu, LQ; Huang, ZS,期刊:European Journal of Medicinal Chemistry, 页码:1572-1581 , 文章类型: Article,,卷期:2011年46-5]
- A series of 3-substituted (5c-5f, 6c-6f) and 4-substituted (10a-10g) oxoisoaporphine derivatives were synthesized. It was found that all these synthetic compounds had IC50 values at micro or nano molar range for cholines...
- Synthesis and biological evaluation of a diazepanone-based library of liposidomycins analogs as MraY inhibitors
[作者:Mravljak, J; Monasson, O; Al-Dabbagh, B; Crouvoisier, M; Bouhss, A; Gravier-Pelletier, C; Le Merrer, Y,期刊:European Journal of Medicinal Chemistry, 页码:1582-1592 , 文章类型: Article,,卷期:2011年46-5]
- New inhibitors of the bacterial tranferase MraY are described. A scaffold strategy based on the diazepanone central core of liposidomycins, natural inhibitors of MraY has been developed. It involves the introduction of k...
- Pharmacophore-based virtual screening and Bayesian model for the identification of potential human leukotriene A4 hydrolase inhibitors
[作者:Thangapandian, S; John, S; Sakkiah, S; Lee, KW,期刊:European Journal of Medicinal Chemistry, 页码:1593-1603 , 文章类型: Article,,卷期:2011年46-5]
- Leukotriene A4 hydrolase (LTA4H), an enzyme involved in the conversion of LTA4 to LTB4, is an emerging and important anti-inflammatory target. This study demonstrates the development of quantitative pharmacophore hypothe...
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