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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共8条记录   Perspectives of Pharmacokinetics and Metabolism in Drug Design [作者：Hsieh, YS,期刊：Current Pharmaceutical Design, 页码：2169-2169 , 文章类型： Editorial Material，,卷期：2009年15-19] Drug Metabolism and Pharmacokinetics in Support of Drug Design [作者：Tang, W; Lu, AYH,期刊：Current Pharmaceutical Design, 页码：2170-2183 , 文章类型： Review，,卷期：2009年15-19] Pharmacokinetics has been recognized as one of the elements determining the probability of success in pharmaceutical research. As a result, compounds are routinely evaluated in drug discovery for their absorption, distri... Drug-Like Property Concepts in Pharmaceutical Design [作者：Di, L; Kerns, EH; Carter, GT,期刊：Current Pharmaceutical Design, 页码：2184-2194 , 文章类型： Review，,卷期：2009年15-19] The pharmaceutical industry is facing an ever increasing challenge to deliver safer and more effective medicines. Traditionally, drug discovery programs were driven solely by potency, regardless of the properties. As a r... Comprehensive Assessment of ADMET Risks in Drug Discovery [作者：Wang, JL,期刊：Current Pharmaceutical Design, 页码：2195-2219 , 文章类型： Review，,卷期：2009年15-19] The high attrition rate in drug development and the deteriorated drug ability as a result of the shifted chemical space of new therapeutic target for unmet medical needs have posed drastic challenges in current drug disc... Metabolite Identification and Profiling in Drug Design: Current Practice and Future Directions [作者：Zhang, ZP; Zhu, MS; Tang, W,期刊：Current Pharmaceutical Design, 页码：2220-2235 , 文章类型： Review，,卷期：2009年15-19] Drug metabolism and pharmacokinetics (DMPK) represents a critical component in support of drug discovery and development. This is because the therapeutic efficacy of a drug is dependent on its exposure which in turn is d... Current Prodrug Design for Drug Discovery [作者：Hsieh, PW; Hung, CF; Fang, JY,期刊：Current Pharmaceutical Design, 页码：2236-2250 , 文章类型： Review，,卷期：2009年15-19] Prodrugs are inactive compounds which are metabolized either chemically or enzymatically in a controlled or predictable manner to the parent active drug inside the body. Prodrugs can enhance the therapeutic efficacy and/... The Role of Hyphenated Chromatography-Mass Spectrometry Techniques in Exploratory Drug Metabolism and Pharmacokinetics [作者：Hsieh, YS; Korfmacher, W,期刊：Current Pharmaceutical Design, 页码：2251-2261 , 文章类型： Review，,卷期：2009年15-19] The advances in high-speed synthesis technologies have produced a large number of biologically active new chemical entities (NCEs) for developability assessment. Current drug discovery efforts have been focused on identi... The Role of Exploratory Drug Metabolism and Pharmacokinetics in New Drug Research: Case Study-Selection of a Thrombin Receptor Antagonist for Development [作者：Hsieh, YS; Cheng, KC; Wang, YG; Chackalamannil, S; Xia, Y; Korfmacher, WA; White, RE,期刊：Current Pharmaceutical Design, 页码：2262-2269 , 文章类型： Review，,卷期：2009年15-19] The rising costs and time associated with bringing new medicines to the market have created a need for a new paradigm for reducing the attrition rates of drug candidates in both preclinical and clinical development stage...