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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共11条记录   Bilirubin Induced Neurological Damage: From the Cell to the Newborn [作者：Ostrow, JD; Tiribelli, C,期刊：Current Pharmaceutical Design, 页码：2868-2868 , 文章类型： Editorial Material，,卷期：2009年15-25] Bilirubin Chemistry and Metabolism; Harmful and Protective Aspects [作者：Vitek, L; Ostrow, JD,期刊：Current Pharmaceutical Design, 页码：2869-2883 , 文章类型： Review，,卷期：2009年15-25] Unconjugated bilirubin (UCB), the principal mammalian bile pigment, is the end product of heme catabolism. Both belong to the superfamily of tetrapyrrolic compounds that serve multiple biological functions in animals and... The Role of ABC Transporters in Protecting Cells from Bilirubin Toxicity [作者：Bellarosa, C; Bortolussi, G; Tiribelli, C,期刊：Current Pharmaceutical Design, 页码：2884-2892 , 文章类型： Review，,卷期：2009年15-25] The ATP-Binding Cassette (ABC) superfamily is the largest transporter family known to translocate a wide variety of exogenous and endogenous substrates across cell membranes. In this chapter we review the potential role ... Blood-Brain Interfaces and Bilirubin-Induced Neurological Diseases [作者：Ghersi-Egea, JF; Gazzin, S; Strazielle, N,期刊：Current Pharmaceutical Design, 页码：2893-2907 , 文章类型： Review，,卷期：2009年15-25] The endothelium of the brain microvessels and the choroid plexus epithelium form highly specialized cellular barriers referred to as blood-brain interfaces through which molecular exchanges take place between the blood a... Redox State, Oxidative Stress, and Molecular Mechanisms of Protective and Toxic Effects of Bilirubin on Cells [作者：Tell, G; Gustincich, S,期刊：Current Pharmaceutical Design, 页码：2908-2914 , 文章类型： Review，,卷期：2009年15-25] Unconjugated bilirubin (UCB) is the major degradation product of the heme catabolism. UCB is a potent antioxidant molecule as well as an indirect pro-oxidant generator. Growing evidence suggests that its major cellular e... Pharmacological Therapies for Unconjugated Hyperbilirubinemia [作者：Cuperus, FJC; Hafkamp, AM; Hulzebos, CV; Verkade, HJ,期刊：Current Pharmaceutical Design, 页码：2927-2938 , 文章类型： Review，,卷期：2009年15-25] Severe unconjugated hyperbilirubinemia, seen mainly in neonates, may cause kernicterus and death. Conventional treatment for severe unconjugated hyperbilirubinemia consists of phototherapy and exchange transfusion. Photo... Polysulfated/Sulfonated Compounds for the Development of Drugs at the Crossroad of Viral Infection and Oncogenesis [作者：Rusnati, M; Urbinati, C,期刊：Current Pharmaceutical Design, 页码：2946-2957 , 文章类型： Review，,卷期：2009年15-25] Virus infection and oncogenesis are two tightly linked processes. Some viruses are endowed with a direct transforming capability and infection activates inflammation that, in turn, favours tumor progression. Also, both i... Intervention Guidelines for Neonatal Hyperbilirubinemia: An Evidence Based Quagmire [作者：Wennberg, RP; Ahlfors, CE; Aravkin, AY,期刊：Current Pharmaceutical Design, 页码：2939-2945 , 文章类型： Review，,卷期：2009年15-25] The American Academy of Pediatrics has proposed guidelines for treating term/near term infants with hyperbilirubinemia based primarily on maintaining the total serum bilirubin concentration (TSB) below a "critical" level... Dendrimers: A Class of Polymers in the Nanotechnology for the Delivery of Active Pharmaceuticals [作者：Samad, A; Alam, MI; Saxena, K,期刊：Current Pharmaceutical Design, 页码：2958-2969 , 文章类型： Review，,卷期：2009年15-25] Dendrimers represent a class of novel polymers having unique molecular architectures characterized by their well-defined structure, with a high degree of molecular uniformity, low polydispersity and properties that make ... Hybrid Drugs for Malaria [作者：Walsh, JJ; Bell, A,期刊：Current Pharmaceutical Design, 页码：2970-2985 , 文章类型： Review，,卷期：2009年15-25] Malaria continues to devastate much of the tropics and sub-tropics in spite of the availability of a number of antimalarial drugs. Part of this problem is due to the disadvantages of the drugs in use, which include (depe... Contribution of Inflammatory Processes to Nerve Cell Toxicity by Bilirubin and Efficacy of Potential Therapeutic Agents [作者：Fernandes, A; Brites, D,期刊：Current Pharmaceutical Design, 页码：2915-2926 , 文章类型： Review，,卷期：2009年15-25] Hyperbilirubinemia is a common condition in neonatal life, where elevated levels of unconjugated bilirubin (UCB) may lead to adverse neurologic outcomes, namely in the presence of inflammatory features. In this review, w...