- DOCK180 Is a Rac Activator That Regulates Cardiovascular Development by Acting Downstream of CXCR4
[作者：Sanematsu, F; Hirashima, M; Laurin, M; Takii, R; Nishikimi, A; Kitajima, K; Ding, G; Noda, M; Murata, Y; Tanaka, Y; Masuko, S; Suda, T; Meno, C; Cote, JF; Nagasawa, T; Fukui, Y,期刊：Circulation Research, 页码：1102-U108 , 文章类型： Article，,卷期：2010年107-9]
- Rationale: During embryogenesis, the CXC chemokine ligand (CXCL) 12 acts on endothelial cells to control cardiac development and angiogenesis. Although biological functions of CXCL12 are exerted in part through activatio...
- Interleukin-17-Dependent Autoimmunity to Collagen Type V in Atherosclerosis
[作者：Dart, ML; Jankowska-Gan, E; Huang, GR; Roenneburg, DA; Keller, MR; Torrealba, JR; Rhoads, A; Kim, B; Bobadilla, JL; Haynes, LD; Wilkes, DS; Burlingham, WJ; Greenspan, DS,期刊：Circulation Research, 页码：1106-U128 , 文章类型： Article，,卷期：2010年107-9]
- Rationale: Considerable evidence shows atherosclerosis to be a chronic inflammatory disease in which immunity to self-antigens contributes to disease progression. We recently identified the collagen type V [col(V)] alpha...
- Variability in Timing of Spontaneous Calcium Release in the Intact Rat Heart Is Determined by the Time Course of Sarcoplasmic Reticulum Calcium Load
[作者：Wasserstrom, JA; Shiferaw, Y; Chen, W; Ramakrishna, S; Patel, H; Kelly, JE; O'Toole, MJ; Pappas, A; Chirayil, N; Bassi, N; Akintilo, L; Wu, MG; Arora, R; Aistrup, GL,期刊：Circulation Research, 页码：1117-U145 , 文章类型： Article，,卷期：2010年107-9]
- Background: Abnormalities in intracellular calcium (Ca) cycling during Ca overload can cause triggered activity because spontaneous calcium release (SCR) activates sufficient Ca-sensitive inward currents to induce delaye...
- Transcriptional Upregulation of Brain-Derived Neurotrophic Factor in Rostral Ventrolateral Medulla by Angiotensin II Significance in Superoxide Homeostasis and Neural Regulation of Arterial Pressure
[作者：Chan, SHH; Wu, CWJ; Chang, AYW; Hsu, KS; Chan, JYH,期刊：Circulation Research, 页码：1127-U180 , 文章类型： Article，,卷期：2010年107-9]
- Rationale: Oxidative stress in rostral ventrolateral medulla (RVLM), where sympathetic premotor neurons for the maintenance of neurogenic vasomotor tone are located, contributes to neural mechanisms of hypertension. Emer...
- Level of G protein-Coupled Receptor Kinase-2 Determines Myocardial Ischemia/Reperfusion Injury via Pro- and Anti-Apoptotic Mechanisms
[作者：Brinks, H; Boucher, M; Gao, E; Chuprun, JK; Pesant, S; Raake, PW; Huang, ZM; Wang, XL; Qiu, G; Gumpert, A; Harris, DM; Eckhart, AD; Most, P; Koch, WJ,期刊：Circulation Research, 页码：1140-U197 , 文章类型： Article，,卷期：2010年107-9]
- Rationale: Activation of prosurvival kinases and subsequent nitric oxide (NO) production by certain G protein-coupled receptors (GPCRs) protects myocardium in ischemia/reperfusion injury (I/R) models. GPCR signaling path...
- Inhibition of Elevated Ca2+/Calmodulin-Dependent Protein Kinase II Improves Contractility in Human Failing Myocardium
[作者：Sossalla, S; Fluschnik, N; Schotola, H; Ort, KR; Neef, S; Schulte, T; Wittkopper, K; Renner, A; Schmitto, JD; Gummert, J; El-Armouche, A; Hasenfuss, G; Maier, LS,期刊：Circulation Research, 页码：1150-U215 , 文章类型： Article，,卷期：2010年107-9]
- Rationale: Heart failure (HF) is known to be associated with increased Ca2+/calmodulin-dependent protein kinase (CaMK)II expression and activity. There is still controversial discussion about the functional role of CaMKI...
- CXCR4-Mediated Bone Marrow Progenitor Cell Maintenance and Mobilization Are Modulated by c-kit Activity
[作者：Cheng, M; Zhou, JL; Wu, M; Boriboun, C; Thorne, T; Liu, T; Xiang, ZF; Zeng, QT; Tanaka, T; Tang, YL; Kishore, R; Tomasson, MH; Miller, RJ; Losordo, DW; Qin, GJ,期刊：Circulation Research, 页码：1083-U78 , 文章类型： Article，,卷期：2010年107-9]
- Rationale: The mobilization of bone marrow (BM) progenitor cells (PCs) is largely governed by interactions between stromal cell-derived factor (SDF)-1 and CXC chemokine receptor (CXCR)4. Ischemic injury disrupts the SDF-...
- Differential Regulation of Proteasome Function in Isoproterenol-Induced Cardiac Hypertrophy
[作者：Drews, O; Tsukamoto, O; Liem, D; Streicher, J; Wang, YB; Ping, PP,期刊：Circulation Research, 页码：1094-U91 , 文章类型： Article，,卷期：2010年107-9]
- Rationale: Proteasomal degradation is altered in many disease phenotypes including cardiac hypertrophy, a prevalent condition leading to heart failure. Our recent investigations identified heterogeneous subpopulations of...
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