- Episodic Exposure to Fine Particulate Air Pollution Decreases Circulating Levels of Endothelial Progenitor Cells
[作者:O'Toole, TE; Hellmann, J; Wheat, L; Haberzettl, P; Lee, J; Conklin, DJ; Bhatnagar, A; Pope, CA,期刊:Circulation Research, 页码:200-200 , 文章类型: Article,,卷期:2010年107-2]
- Rationale: Acute and chronic exposures to airborne particulate matter (PM) have been linked in epidemiological studies to a wide spectrum of cardiovascular disorders that are characterized by a dysfunctional endothelium....
- Retinoic Acid and VEGF Delay Smooth Muscle Relative to Endothelial Differentiation to Coordinate Inner and Outer Coronary Vessel Wall Morphogenesis
[作者:Azambuja, AP; Portillo-Sanchez, V; Rodrigues, MV; Omae, SV; Schechtman, D; Strauss, BE; Costanzi-Strauss, E; Krieger, JE; Perez-Pomares, JM; Xavier-Neto, J,期刊:Circulation Research, 页码:204-204 , 文章类型: Article,,卷期:2010年107-2]
- Rationale: Major coronary vessels derive from the proepicardium, the cellular progenitor of the epicardium, coronary endothelium, and coronary smooth muscle cells (CoSMCs). CoSMCs are delayed in their differentiation rel...
- Structure/Function Relationships of Apolipoprotein A-I Mimetic Peptides Implications for Antiatherogenic Activities of High-Density Lipoprotein
[作者:D'Souza, W; Stonik, JA; Murphy, A; Demosky, SJ; Sethi, AA; Moore, XL; Chin-Dusting, J; Remaley, AT; Sviridov, D,期刊:Circulation Research, 页码:217-217 , 文章类型: Article,,卷期:2010年107-2]
- Rationale: Apolipoprotein (apoA)-I mimetic peptides are a promising type of antiatherosclerosis therapy, but how the structural features of these peptides relate to the multiple antiatherogenic functions of HDL is poorly...
- Oxidative Posttranslational Modifications Mediate Decreased SERCA Activity and Myocyte Dysfunction in G alpha q-Overexpressing Mice
[作者:Lancel, S; Qin, FZ; Lennon, SL; Zhang, JM; Tong, XY; Mazzini, MJ; Kang, YJ; Siwik, DA; Cohen, RA; Colucci, WS,期刊:Circulation Research, 页码:228-232 , 文章类型: Article,,卷期:2010年107-2]
- Background: Myocyte contractile dysfunction occurs in pathological remodeling in association with abnormalities in calcium regulation. Mice with cardiac myocyte-specific overexpression of G alpha q develop progressive le...
- Preferential Oxidation of Triacylglyceride-Derived Fatty Acids in Heart Is Augmented by the Nuclear Receptor PPAR alpha
[作者:Banke, NH; Wende, AR; Leone, TC; O'Donnell, JM; Abel, ED; Kelly, DP; Lewandowski, ED,期刊:Circulation Research, 页码:233-241 , 文章类型: Article,,卷期:2010年107-2]
- Rationale: Long chain fatty acids (LCFAs) are the preferred substrate for energy provision in hearts. However, the contribution of endogenous triacylglyceride (TAG) turnover to LCFA oxidation and the overall dependence o...
- Increased Endothelial Exocytosis and Generation of Endothelin-1 Contributes to Constriction of Aged Arteries
[作者:Goel, A; Su, BG; Flavahan, S; Lowenstein, CJ; Berkowitz, DE; Flavahan, NA,期刊:Circulation Research, 页码:242-242 , 文章类型: Article,,卷期:2010年107-2]
- Rationale: Circulating levels of endothelin (ET)-1 and endogenous ETA-mediated constriction are increased in human aging. The mechanisms responsible are not known. Objective: Investigate the storage, release, and activit...
- Smad-Dependent and Smad-Independent Induction of Id1 by Prostacyclin Analogues Inhibits Proliferation of Pulmonary Artery Smooth Muscle Cells In Vitro and In Vivo
[作者:Yang, J; Li, XH; Al-Lamki, RS; Southwood, M; Zhao, J; Lever, AM; Grimminger, F; Schermuly, RT; Morrell, NW,期刊:Circulation Research, 页码:252-252 , 文章类型: Article,,卷期:2010年107-2]
- Rationale: Mutations in the bone morphogenetic protein type II receptor (BMPR-II) are responsible for the majority of cases of heritable pulmonary arterial hypertension (PAH). Mutations lead to reduced Smad1/5driven expr...
- Central and Peripheral Mechanisms of T-Lymphocyte Activation and Vascular Inflammation Produced by Angiotensin II-Induced Hypertension
[作者:Marvar, PJ; Thabet, SR; Guzik, TJ; Lob, HE; McCann, LA; Weyand, C; Gordon, FJ; Harrison, DG,期刊:Circulation Research, 页码:263-263 , 文章类型: Article,,卷期:2010年107-2]
- Rationale: We have previously found that T lymphocytes are essential for development of angiotensin II-induced hypertension; however, the mechanisms responsible for T-cell activation in hypertension remain undefined. Obj...
- Activation of Vascular Smooth Muscle Parathyroid Hormone Receptor Inhibits Wnt/beta-Catenin Signaling and Aortic Fibrosis in Diabetic Arteriosclerosis
[作者:Cheng, SL; Shao, JS; Halstead, LR; Distelhorst, K; Sierra, O; Towler, DA,期刊:Circulation Research, 页码:271-271 , 文章类型: Article,,卷期:2010年107-2]
- Rationale: Vascular fibrosis and calcification contribute to diabetic arteriosclerosis, impairing Windkessel physiology necessary for distal tissue perfusion. Wnt family members, upregulated in arteries by the low-grade ...
- Inhibition of Delta-Like-4-Mediated Signaling Impairs Reparative Angiogenesis After Ischemia
[作者:Zen, AA; Oikawa, A; Bazan-Peregrino, M; Meloni, M; Emanueli, C; Madeddu, P,期刊:Circulation Research, 页码:283-283 , 文章类型: Article,,卷期:2010年107-2]
- Rationale: Notch signaling regulates vascular development. However, the implication of the Notch ligand Delta-like 4 (Dll4) in postischemic angiogenesis remains unclear. Objective: We investigated the role of Dll4/Notch ...
- Myocardin-Related Transcription Factor-A Controls Myofibroblast Activation and Fibrosis in Response to Myocardial Infarction
[作者:Small, EM; Thatcher, JE; Sutherland, LB; Kinoshita, H; Gerard, RD; Richardson, JA; DiMaio, JM; Sadek, H; Kuwahara, K; Olson, EN,期刊:Circulation Research, 页码:294-294 , 文章类型: Article,,卷期:2010年107-2]
- Rationale: Myocardial infarction (MI) results in loss of cardiac myocytes in the ischemic zone of the heart, followed by fibrosis and scar formation, which diminish cardiac contractility and impede angiogenesis and repai...
- Cardiomyogenesis in the Adult Human Heart
[作者:Kajstura, J; Urbanek, K; Perl, S; Hosoda, T; Zheng, HQ; Ogorek, B; Ferreira-Martins, J; Goichberg, P; Rondon-Clavo, C; Sanada, F; D'Amario, D; Rota, M; del Monte, F; Orlic, D; Tisdale, J; Leri, A; Anversa, P,期刊:Circulation Research, 页码:305-305 , 文章类型: Article,,卷期:2010年107-2]
- Rationale: The ability of the human heart to regenerate large quantities of myocytes remains controversial, and the extent of myocyte renewal claimed by different laboratories varies from none to nearly 20% per year. Obj...
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