- Nitric oxide-mediated modulation of calcium/calmodulin-dependent protein kinase II
[作者:Song, T; Hatano, N; Kambe, T; Miyamoto, Y; Ihara, H; Yamamoto, H; Sugimoto, K; Kume, K; Yamaguchi, F; Tokuda, M; Watanabe, Y,期刊:Biochemical Journal, 页码:223-231 , 文章类型: Article,,卷期:2008年412-2]
- The mechanisms of NO inhibition of CaMK [Ca2+/CaM (calmodulin)-dependent protein kinase] 11 activity were studied. In rat pituitary tumour GH3 cells, TRH [thyrotrophin (TSH)-releasing hormone]-stimulated phosphorylation ...
- Monitoring conformational changes during the catalytic cycle of OpuAA, the ATPase subunit of the ABC transporter OpuA from Bacillus subtilis
[作者:Horn, C; Jenewein, S; Tschapek, B; Bolischen, W; Metzger, S; Bremer, E; Schmitt, L,期刊:Biochemical Journal, 页码:233-244 , 文章类型: Article,,卷期:2008年412-2]
- The ABC transporter (ATP-binding-cassette transporter) OpuA is one of five membrane transport systems in Bacillus subtilis that mediate osmoprotection by importing compatible solutes. Just like all bacteria] and archaeal...
- The crystal structure of peroxymyoglobin generated through cryoradiolytic reduction of myoglobin compound III during data collection
[作者:Hersleth, HP; Hsiao, YW; Ryde, U; Gorbitz, CH; Andersson, KK,期刊:Biochemical Journal, 页码:257-264 , 文章类型: Article,,卷期:2008年412-2]
- Myoglobin has the ability to react with hydrogen peroxide, generating high-valent complexes similar to peroxidases (compounds I and II), and in the presence of excess hydrogen peroxide a third intermediate, compound III,...
- Cep57, a multidomain protein with unique microtubule and centrosomal localization domains
[作者:Momotani, K; Khromov, AS; Miyake, T; Stukenberg, RT; Somlyo, AV,期刊:Biochemical Journal, 页码:265-273 , 文章类型: Article,,卷期:2008年412-2]
- The present study demonstrates different functional domains of a recently described centrosomal protein, Cep57 (centrosomal protein 57). Endogenous Cep57 protein and ectopic expression of full-length protein or the N-ter...
- Diverse roles for chloroplast stromal and thylakoid-bound ascorbate peroxidases in plant stress responses
[作者:Kangasjarvi, S; Lepisto, A; Hannikainen, K; Piippo, M; Luomala, EM; Aro, EM; Rintamaki, E,期刊:Biochemical Journal, 页码:275-285 , 文章类型: Article,,卷期:2008年412-2]
- Photosynthetic light reactions comprise a significant source of hydrogen peroxide (H2O2) in illuminated leaves. APXs (ascorbate peroxidases) reduce H2O2 to water and play an important role in the antioxidant system of pl...
- Negative-feedback regulation of FGF signalling by DUSP6/MKP-3 is driven by ERK1/2 and mediated by Ets factor binding to a conserved site within the DUSP6/MKP-3 gene promoter
[作者:Ekerot, M; Stavridis, MP; Delavaine, L; Mitchell, MP; Staples, C; Owens, DM; Keenan, ID; Dickinson, RJ; Storey, KG; Keyse, SM,期刊:Biochemical Journal, 页码:287-298 , 文章类型: Article,,卷期:2008年412-2]
- DUSP6 (dual-specificity phosphatase 6), also known as MKP-3 [MAPK (mitogen-activated protein kinase) phosphatase-3] specifically inactivates ERK1/2 (extracellular-signal-regulated kinase 1/2) in vitro and in vivo. DUSP6/...
- The Rb/E2F pathway and Ras activation regulate RecQ helicase gene expression
[作者:Liu, YQ; El-Naggar, S; Clem, B; Chesney, J; Dean, DC,期刊:Biochemical Journal, 页码:299-306 , 文章类型: Article,,卷期:2008年412-2]
- Disruption of the Rb (retinoblastoma protein)/E2F cell-cycle pathway and Ras activation are two of the most frequent events in cancer, and both of these mutations place oncogenic stress on cells to increase DNA replicati...
- Splice-switching efficiency and specificity for oligonucleotides with locked nucleic acid monomers
[作者:Guterstam, P; Lindgren, M; Johansson, H; Tedebark, U; Wengel, J; El Andaloussi, S; Langel, U,期刊:Biochemical Journal, 页码:307-313 , 文章类型: Article,,卷期:2008年412-2]
- The use of antisense oligonucleotides to modulate splicing patterns has gained increasing attention as a therapeutic platform and, hence, the mechanisms of splice-switching oligonucleotides are of interest. Cells express...
- The intact CFTR protein mediates ATPase rather than adenylate kinase activity
[作者:Ramjeesingh, M; Ugwu, F; Stratford, FLL; Huan, LJ; Li, CH; Bear, CE,期刊:Biochemical Journal, 页码:315-321 , 文章类型: Article,,卷期:2008年412-2]
- The two NBDs (nucleotide-binding domains) of ABC (ATP-binding-cassette) proteins function in a complex to mediate ATPase activity and this activity has been linked to their regulated transport activity. A similar model h...
- Critical role for cross-linking of trimeric lectin domains of surfactant protein D in antiviral activity against influenza A virus
[作者:Tecle, T; White, MR; Sorensen, G; Gantz, D; Kacak, N; Holmskov, U; Smith, K; Crouch, EC; Hartshorn, KL,期刊:Biochemical Journal, 页码:323-329 , 文章类型: Article,,卷期:2008年412-2]
- Collectins are multimeric host defence lectins with trimeric CRDs (carbohydrate-recognition domains) and collagen and N-terminal domains that form higher-order structures composed of four or more trimers. Recombinant tri...
- Proximal mutations at the type 1 copper site of CotA laccase: spectroscopic, redox, kinetic and structural characterization of I494A and L386A mutants
[作者:Durao, P; Chen, ZJ; Silva, CS; Soares, CM; Pereira, MM; Todorovic, S; Hildebrandt, P; Bento, I; Lindley, PF; Martins, LO,期刊:Biochemical Journal, 页码:339-346 , 文章类型: Article,,卷期:2008年412-2]
- In the present study the CotA laccase from Bacillus subtilis has been mutated at two hydrophobic residues in the vicinity of the type I copper site. The mutation of Leu(386) to an alanine residue appears to cause only ve...
- Analysis of endogenous Bax complexes during apoptosis using blue native PAGE: implications for Bax activation and oligomerization
[作者:Valentijn, AJ; Upton, JP; Gilmore, AP,期刊:Biochemical Journal, 页码:347-357 , 文章类型: Article,,卷期:2008年412-2]
- Bax, a pro-apoptotic Bcl-2 family protein, translocates to mitochondria during apoptosis, where it causes MOMP (mitochondrial outer membrane permeabilization). MOMP releases proapoptotic factors, such as cytochrome c and...
- Inhibition of the interaction between protein phosphatase 1 glycogen-targeting subunit and glycogen phosphorylase increases glycogen synthesis in primary rat hepatocytes
[作者:Zibrova, D; Grempler, R; Streicher, R; Kauschke, SG,期刊:Biochemical Journal, 页码:359-366 , 文章类型: Article,,卷期:2008年412-2]
- In Type 2 diabetes, increased glycogenolysis contributes to the hyperglycaemic state, therefore the inhibition of GP (glycogen phosphorylase), a key glycogenolyfic enzyme, is one of the possibilities to lower plasma gluc...
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