- Identification of novel small-molecule histone deacetylase inhibitors by medium-throughput screening using a fluorigenic assay
[作者:Wegener, D; Hildmann, C; Riester, D; Schober, A; Meyer-Almes, FJ; Deubzer, HE; Oehme, I; Witt, O; Lang, S; Jaensch, M; Makarov, V; Lange, C; Busse, B; Schwienhorst, A,期刊:Biochemical Journal, 页码:143-150 , 文章类型: Article,,卷期:2008年413-1]
- HDACs (histone deacetylases) are considered to be among the most important enzymes that regulate gene expression in eukaryotic cells. In general, increased levels of histone acetylation are associated with increased tran...
- A functional link between housekeeping selenoproteins and phase II enzymes
[作者:Sengupta, A; Carlson, BA; Weaver, JA; Novoselov, SV; Fomenko, DE; Gladyshev, VN; Hatfield, DL,期刊:Biochemical Journal, 页码:151-161 , 文章类型: Article,,卷期:2008年413-1]
- See (selenocysteine) is biosynthesized on its tRNA and incorporated into selenium-containing proteins (selenoproteins) as the 21st amino acid residue. Selenoprotein synthesis is dependent on See tRNA and the expression o...
- The role of the diphthamide-containing loop within eukaryotic elongation factor 2 in ADP-ribosylation by Pseudomonas aeruginosa exotoxin A
[作者:Zhang, Y; Liu, S; Lajoie, G; Merrill, AR,期刊:Biochemical Journal, 页码:163-174 , 文章类型: Article,,卷期:2008年413-1]
- eEF2 (eukaryotic elongation factor 2) contains a post-translationally modified histidine residue, known as diphthamide, which is the specific ADP-ribosylation target of diphtheria toxin, cholix toxin and Pseudomonas aeru...
- The tyrosine phosphatase CD148 interacts with the p85 regulatory subunit of phosphoinositide 3-kinase
[作者:Tsuboi, N; Utsunomiya, T; Roberts, RL; Ito, H; Takahashi, K; Noda, M; Takahashi, T,期刊:Biochemical Journal, 页码:193-200 , 文章类型: Article,,卷期:2008年413-1]
- CD148 is a transmembrane tyrosine phosphatase that has been implicated in the regulation of cell growth and transformation. However, the signalling mechanisms of CD148 are incompletely understood. To identify the specifi...
- Mutations of beta-arrestin 2 that limit self-association also interfere with interactions with the beta(2)-adrenoceptor and the ERK1/2 MAPKs: implications for beta(2)-adrenoceptor signalling via the ERK1/2 MAPKs
[作者:Xu, TR; Baillie, GS; Bhari, N; Holislay, TM; Pitt, AM; Adams, DR; Kolch, W; Houslay, MD; Milligan, G,期刊:Biochemical Journal, 页码:51-60 , 文章类型: Article,,卷期:2008年413-1]
- FRET (fluorescence resonance energy transfer) and co-immuno-precipitation studies confirmed the capacity of beta-arrestin 2 to self-associate. Amino acids potentially involved in direct protein-protein interaction were i...
- Analysis of carboxyl tail function in the skeletal muscle Cl- channel hClC-1
[作者:Ma, L; Rychkov, GY; Hughes, BP; Bretag, AH,期刊:Biochemical Journal, 页码:61-69 , 文章类型: Article,,卷期:2008年413-1]
- Human ClC-1 (skeletal muscle Cl- channel) has a long cytoplasmic C-tail (carboxyl tail), containing two CBS (cystathionine beta-synthase) domains, which is very important for channel function. We have now investigated it...
- Specific effects of KChIP3/calsenilin/DREAM, but not KChIPs 1, 2 and 4, on calcium signalling and regulated secretion in PC12 cells
[作者:Venn, N; Haynes, LP; Burgoyne, RD,期刊:Biochemical Journal, 页码:71-80 , 文章类型: Article,,卷期:2008年413-1]
- The KChIPs (K+ channel-interacting proteins) are members of the NCS (neuronal calcium sensor) protein family of Ca2+-binding proteins. It is unclear to what extent the KChIPs have distinct functions although they all int...
- Kinetic, thermodynamic and X-ray structural insights into the interaction of melatonin and analogues with quinone reductase 2
[作者:Calamini, B; Santarsiero, BD; Boutin, JA; Mesecar, AD,期刊:Biochemical Journal, 页码:81-91 , 文章类型: Article,,卷期:2008年413-1]
- Melatonin exerts its biological effects through at least two transmembrane G-protein-coupled receptors, MT1 and MT2, and a lower-affinity cytosolic binding site, designated MT3. MT3 has recently been identified as QR2 (q...
- Mn2+-dependent ADP-ribose/CDP-alcohol pyrophosphatase: a novel metallophosphoesterase family preferentially expressed in rodent immune cells
[作者:Canales, J; Fernandez, A; Ribeiro, JM; Cabezas, A; Rodrigues, JR; Cameselle, JC; Costas, MJ,期刊:Biochemical Journal, 页码:103-113 , 文章类型: Article,,卷期:2008年413-1]
- ADPRibase-Mn (Mn2+-dependent ADP-ribose/CDP-alcohol pyrophosphatase) was earlier isolated from rat liver supernatants after separation from ADPRibase-I and ADPRibase-II (Mg2+-activated ADP-ribose pyrophosphatases devoid ...
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