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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共17条记录   Mechanisms of neuronal death in disease: defining the models and the players [作者：Ribe, EM; Serrano-Saiz, E; Akpan, N; Troy, CM,期刊：Biochemical Journal, 页码：165-182 , 文章类型： Review，,卷期：2008年415-2] Dysregulation of life and death at the cellular level leads to a variety of diseases. In the nervous system, aberrant neuronal death is an outstanding feature of neurodegenerative diseases. Since the discovery of the cas... Conformational changes and flexibility in T-cell receptor recognition of peptide-MHC complexes [作者：Armstrong, KM; Piepenbrink, KH; Baker, BM,期刊：Biochemical Journal, 页码：183-196 , 文章类型： Review，,卷期：2008年415-2] A necessary feature of the immune system, TCR (T-cell receptor) cross-reactivity has been implicated in numerous autoimmune pathologies and is an underlying cause of transplant rejection. Early studies of the interaction... Comparison of the EGFR resistance mutation profiles generated by EGFR-targeted tyrosine kinase inhibitors and the impact of drug combinations [作者：Avizienyte, E; Ward, RA; Garner, AP,期刊：Biochemical Journal, 页码：197-206 , 文章类型： Article，,卷期：2008年415-2] Recent clinical data indicates that the emergence Of mutant drug-resistant kinase alleles may be particularly relevant for targeted kinase inhibitors. In order to explore how different classes of targeted therapies impac... Diffusible amyloid oligomers trigger systemic amyloidosis in mice [作者：Senthilkumar, S; Chang, E; Jayakumar, R,期刊：Biochemical Journal, 页码：207-215 , 文章类型： Article，,卷期：2008年415-2] AA (amyloid protein A) amyloidosis in mice is markedly accelerated when the animals are given, in addition to an inflammatory stimulus, an intravenous injection of protein extracted from AA-laden mouse tissue. Previous f... Structural and kinetic differences between human and Aspergillus fumigatus D-glucosamine-6-phosphate N-acetyltransferase [作者：Hurtado-Guerrero, R; Raimi, OG; Min, J; Zeng, H; Vallius, L; Shepherd, S; Ibrahim, AFM; Wu, H; Plotnikov, AN; van Aalten, DMF,期刊：Biochemical Journal, 页码：217-223 , 文章类型： Article，,卷期：2008年415-2] Aspergillus fumigatus is the causative agent of aspergillosis, a frequently invasive colonization of the lungs of immuno-compromised patients. GNA1 (D-glucosamine-6-phosphate N-acetyltransferase) catalyses the acetylatio... Dipeptidyl-peptidase I does not functionally compensate for the loss of tripeptidyl-peptidase I in the neurodegenerative disease late-infantile neuronal ceroid lipofuscinosis [作者：Kim, KH; Pham, CT; Sleat, DE; Lobel, P,期刊：Biochemical Journal, 页码：225-232 , 文章类型： Article，,卷期：2008年415-2] LINCL (late-infantile neuronal ceroid lipofuscinosis) is a fatal neurodegenerative disease resulting from mutations in the gene encoding the lysosomal protease TPPI (tripeptidyl-peptidase I). TPPI is expressed ubiquitous... Human pancreatic beta-cell glucokinase: subcellular localization and glucose repression signalling function in the yeast cell [作者：Riera, A; Ahuatzi, D; Herrero, P; Garcia-Gimeno, MA; Sanz, P; Moreno, F,期刊：Biochemical Journal, 页码：233-239 , 文章类型： Article，,卷期：2008年415-2] Human GK(beta) (pancreatic beta-cell glucokinase) is the main glucose-phosphorylating enzyme in pancreatic beta-cells. It shares several structural, catalytic and regulatory properties with Hxk2 (hexokinase 2) from Sacch... Adaptor protein Lnk associates with Tyr(568) in c-Kit [作者：Gueller, S; Gery, S; Nowak, V; Liu, LQ; Serve, H; Koeffler, HP,期刊：Biochemical Journal, 页码：241-245 , 文章类型： Article，,卷期：2008年415-2] The adaptor protein Lnk is expressed in haemopoietic cells and plays a critical role in haemopoiesis. Animal model Studies demonstrated that Lnk acts as a broad inhibitor of signalling pathways in haemopoietic lineages. ... A novel protein phosphatase indirectly regulates phytochrome-interacting factor 3 via phytochrome [作者：Phee, BK; Kim, JI; Shin, DH; Yoo, J; Park, KJ; Han, YJ; Kwon, YK; Cho, MH; Jeon, JS; Bhoo, SH; Hahn, TR,期刊：Biochemical Journal, 页码：247-255 , 文章类型： Article，,卷期：2008年415-2] Light signal transduction in plants involves an intricate series of pathways which is finely regulated by interactions between specific signalling proteins, as well as by protein modifications Such as phosphorylation and... Structure and function of SirC from Bacillus megaterium: a metal-binding precorrin-2 dehydrogenase [作者：Schubert, HL; Rose, RS; Leech, HK; Brindley, AA; Hill, CR; Rigby, SEJ; Warren, MJ,期刊：Biochemical Journal, 页码：257-263 , 文章类型： Article，,卷期：2008年415-2] In Bacillus megaterium, the synthesis of vitamin B-12 (cobalamin) and sirohaem diverges at sirohydrochlorin along the branched modified tetrapyrrole biosynthetic pathway. This key intermediate is made by the action of Si... Urokinase induces survival or pro-apoptotic signals in human mesangial cells depending on the apoptotic stimulus [作者：Tkachuk, N; Kiyan, J; Tkachuk, S; Kiyan, R; Shushakova, N; Haller, H; Dumler, I,期刊：Biochemical Journal, 页码：265-273 , 文章类型： Article，,卷期：2008年415-2] Deregulated apoptosis of MCs (mesangial cells) is associated with a number of kidney diseases including end-stage diabetic nephropathy. Cell death by apoptosis is a tightly orchestrated event, whose mechanisms are not co... How do surfactants and DTT affect the size, dynamics, activity and growth of soluble lysozyme aggregates? [作者：Kumar, S; Ravi, VK; Swaminathan, R,期刊：Biochemical Journal, 页码：275-288 , 文章类型： Article，,卷期：2008年415-2] The early intermediates in the protein aggregation pathway, the elusive soluble aggregates, play a pivotal role in growth and maturation of ordered aggregates Such as amyloid fibrils. Blocking the growth of soluble oligo... Modulation of hepatocyte nuclear factor-4 alpha function by the peroxisome-proliferator-activated receptor-gamma co-activator-1 alpha in the acute-phase response [作者：Wang, ZY; Burke, PA,期刊：Biochemical Journal, 页码：289-296 , 文章类型： Article，,卷期：2008年415-2] HNF-4 alpha (hepatocyte nuclear factor-4 alpha) is a key regulator of liver-specific gene expression. To understand the mechanisms governing the regulation of HNF-4 alpha function during the APR (acute-phase response), t... Identification and characterization of FUS/TLS as a new target of ATM [作者：Gardiner, M; Toth, R; Vandermoere, F; Morrice, NA; Rouse, J,期刊：Biochemical Journal, 页码：297-307 , 文章类型： Article，,卷期：2008年415-2] ATM (ataxia-telangiectasia mutated), ATR (ATM- and Rad3-related) and DNA-PK (DNA-dependent protein kinase), important regulators of genome stability, belong to the PIKK (phosphoinositide 3-kinase-like kinase) family of p... Metabolic pathways in Anopheles stephensi mitochondria [作者：Giulivi, C; Ross-Inta, C; Horton, AA; Luckhart, S,期刊：Biochemical Journal, 页码：309-316 , 文章类型： Article，,卷期：2008年415-2] No studies have been performed on the mitochondria of malaria vector mosquitoes. This information Would be valuable in understanding mosquito aging and detoxification of insecticides, two parameters that have a significa... Post-translational enzyme modification by the phosphopantetheinyl transferase is required for lysine and penicillin biosynthesis but not for roquefortine or fatty acid formation in Penicillium chrysogenum [作者：Garcia-Estrada, C; Ullan, RV; Velasco-Conde, T; Godio, RP; Teijeira, F; Vaca, I; Feltrer, R; Kosalkova, K; Mauriz, E; Martin, JF,期刊：Biochemical Journal, 页码：317-324 , 文章类型： Article，,卷期：2008年415-2] NRPSs (non-ribosomal peptide synthetases) and PKSs (polyketide synthases) require post-translational phosphopantetheinylation to become active. This reaction is catalysed by a PPTase (4'-phosphopantetheinyl transferase)....