- Cooperation between the INO80 Complex and Histone Chaperones Determines Adaptation of Stress Gene Transcription in the Yeast Saccharomyces cerevisiae
[作者：Klopf, E; Paskova, L; Sole, C; Mas, G; Petryshyn, A; Posas, F; Wintersberger, U; Ammerer, G; Schuller, C,期刊：Molecular and Cellular Biology, 页码：4994-5007 , 文章类型： Article，,卷期：2009年29-18]
- In yeast, environmental stresses provoke sudden and dramatic increases in gene expression at stress-inducible loci. Stress gene transcription is accompanied by the transient eviction of histones from the promoter and the...
- Functional Connection between Deimination and Deacetylation of Histones
[作者：Denis, H; Deplus, R; Putmans, P; Yamada, M; Metivier, R; Fuks, F,期刊：Molecular and Cellular Biology, 页码：4982-4993 , 文章类型： Article，,卷期：2009年29-18]
- Histone methylation plays key roles in regulating chromatin structure and function. The recent identification of enzymes that antagonize or remove histone methylation offers new opportunities to appreciate histone methyl...
- The Direct Binding of Mrc1, a Checkpoint Mediator, to Mcm6, a Replication Helicase, Is Essential for the Replication Checkpoint against Methyl Methanesulfonate-Induced Stress
[作者：Komata, M; Bando, M; Araki, H; Shirahige, K,期刊：Molecular and Cellular Biology, 页码：5008-5019 , 文章类型： Article，,卷期：2009年29-18]
- Mrc1 plays a role in mediating the DNA replication checkpoint. We surveyed replication elongation proteins that interact directly with Mrc1 and identified a replicative helicase, Mcm6, as a specific Mrc1-binding protein....
- Two GW Repeat Proteins Interact with Tetrahymena thermophila Argonaute and Promote Genome Rearrangement
[作者：Bednenko, J; Noto, T; DeSouza, LV; Siu, KWM; Pearlman, RE; Mochizuki, K; Gorovsky, MA,期刊：Molecular and Cellular Biology, 页码：5020-5030 , 文章类型： Article，,卷期：2009年29-18]
- In conjugating Tetrahymena thermophila, massive DNA elimination occurs upon the development of the new somatic genome from the germ line genome. Small, similar to 28-nucleotide scan RNAs (scnRNAs) and Twi1p, an Argonaute...
- The Tumor Suppressor Functions of p27(kip1) Include Control of the Mesenchymal/Amoeboid Transition
[作者：Berton, S; Belletti, B; Wolf, K; Canzonieri, V; Lovat, F; Vecchione, A; Colombatti, A; Friedl, P; Baldassarre, G,期刊：Molecular and Cellular Biology, 页码：5031-5045 , 文章类型： Article，,卷期：2009年29-18]
- In many human cancers, p27 downregulation correlates with a worse prognosis, suggesting that p27 levels could represent an important determinant in cell transformation and cancer development. Using a mouse model system b...
- The Absence of Caveolin-1 Increases Proliferation and Anchorage-Independent Growth by a Rac-Dependent, Erk-Independent Mechanism
[作者：Cerezo, A; Guadamillas, MC; Goetz, JG; Sanchez-Perales, S; Klein, E; Assoian, RK; del Pozo, MA,期刊：Molecular and Cellular Biology, 页码：5046-5059 , 文章类型： Article，,卷期：2009年29-18]
- Anchorage-independent growth (AIG) of cancer cells requires escape from integrin-mediated signals. A protein frequently downregulated in cancer, caveolin-1 (Cav1), mediates integrin control of several growth-regulatory p...
- The Irs1 Branch of the Insulin Signaling Cascade Plays a Dominant Role in Hepatic Nutrient Homeostasis
[作者：Guo, S; Copps, KD; Dong, XC; Park, S; Cheng, ZY; Pocai, A; Rossetti, L; Sajan, M; Farese, RV; White, MF,期刊：Molecular and Cellular Biology, 页码：5070-5083 , 文章类型： Article，,卷期：2009年29-18]
- We used a Cre-loxP approach to generate mice with varied expression of hepatic Irs1 and Irs2 to establish the contribution of each protein to hepatic nutrient homeostasis. While nutrient-sensitive transcripts were expres...
- SOCS1, SOCS3, and PIAS1 Promote Myogenic Differentiation by Inhibiting the Leukemia Inhibitory Factor-Induced JAK1/STAT1/STAT3 Pathway
[作者：Diao, YR; Wang, X; Wu, ZG,期刊：Molecular and Cellular Biology, 页码：5084-5093 , 文章类型： Article，,卷期：2009年29-18]
- We recently showed that a leukemia inhibitory factor (LIF)-engaged signaling pathway consisting of JAK1, STAT1, and STAT3 plays dual roles in myogenic differentiation: while it participates in myoblast proliferation, it ...
- The Multiple Endocrine Neoplasia Type 1 (MEN1) Tumor Suppressor Regulates Peroxisome Proliferator-Activated Receptor gamma-Dependent Adipocyte Differentiation
[作者：Dreijerink, KMA; Varier, RA; van Beekum, O; Jeninga, EH; Hoppener, JWM; Lips, CJM; Kummer, JA; Kalkhoven, E; Timmers, HTM,期刊：Molecular and Cellular Biology, 页码：5060-5069 , 文章类型： Article，,卷期：2009年29-18]
- Menin, the product of the MEN1 (multiple endocrine neoplasia type 1) tumor suppressor gene, is involved in activation of gene transcription as part of an MLL1 (mixed-lineage leukemia 1)/MLL2 (KMT2A/B)containing protein c...
- Mechanoregulation of Proliferation
[作者：Jiang, XG; Austin, PF; Niederhoff, RA; Manson, SR; Riehm, JJ; Cook, BL; Pengue, G; Chitaley, K; Nakayama, K; Nakayama, KI; Weintraub, SJ,期刊：Molecular and Cellular Biology, 页码：5104-5114 , 文章类型： Article，,卷期：2009年29-18]
- The proliferation of all nontransformed adherent cells is dependent upon the development of mechanical tension within the cell; however, little is known about the mechanisms by which signals regulated by mechanical tensi...
- Acetylated NPM1 Localizes in the Nucleoplasm and Regulates Transcriptional Activation of Genes Implicated in Oral Cancer Manifestation
[作者：Shandilya, J; Swaminathan, V; Gadad, SS; Choudhari, R; Kodaganur, GS; Kundu, TK,期刊：Molecular and Cellular Biology, 页码：5115-5127 , 文章类型： Article，,卷期：2009年29-18]
- Nucleophosmin (NPM1) is a multifunctional protein involved in the regulation of centrosome duplication, ribosome biogenesis, genomic stability, histone chaperone function, and transcription. Overexpression of NPM1 is ass...
- Regulation of Aurora B Expression by the Bromodomain Protein Brd4
[作者：You, JX; Li, Q; Wu, C; Kim, J; Ottinger, M; Howley, PM,期刊：Molecular and Cellular Biology, 页码：5094-5103 , 文章类型： Article，,卷期：2009年29-18]
- The bromodomain protein Brd4 plays critical roles in cellular proliferation and cell cycle progression. In this study, we investigated the involvement of Brd4 in cell cycle regulation and observed aberrant chromosome seg...
- A Novel Gene Essential for the Development of Single Positive Thymocytes
[作者：Kakugawa, K; Yasuda, T; Miura, I; Kobayashi, A; Fukiage, H; Satoh, R; Matsuda, M; Koseki, H; Wakana, S; Kawamoto, H; Yoshida, H,期刊：Molecular and Cellular Biology, 页码：5128-5135 , 文章类型： Article，,卷期：2009年29-18]
- A critical step during intrathymic T-cell development is the transition of CD4(+) CD8(+) double-positive (DP) cells to the major histocompatibility complex class I (MHC-I)-restricted CD4(-) CD8(+) and MHC-II-restricted C...
- mTORC1 Hyperactivity Inhibits Serum Deprivation-Induced Apoptosis via Increased Hexokinase II and GLUT1 Expression, Sustained Mcl-1 Expression, and Glycogen Synthase Kinase 3 beta Inhibition
[作者：Bhaskar, PT; Nogueira, V; Patra, KC; Jeon, SM; Park, Y; Robey, RB; Hay, N,期刊：Molecular and Cellular Biology, 页码：5136-5147 , 文章类型： Article，,卷期：2009年29-18]
- The current concept is that Tsc-deficient cells are sensitized to apoptosis due to the inhibition of Akt activity by the negative feedback mechanism induced by the hyperactive mTORC1. Unexpectedly, however, we found that...
- The Fission Yeast HIRA Histone Chaperone Is Required for Promoter Silencing and the Suppression of Cryptic Antisense Transcripts
[作者：Anderson, HE; Wardle, J; Korkut, SV; Murton, HE; Lopez-Maury, L; Bahler, J; Whitehall, SK,期刊：Molecular and Cellular Biology, 页码：5158-5167 , 文章类型： Article，,卷期：2009年29-18]
- The assembly of nucleosomes by histone chaperones is an important component of transcriptional regulation. Here, we have assessed the global roles of the HIRA histone chaperone in Schizosaccharomyces pombe. Microarray an...
- The Concerted Action of Msh2 and UNG Stimulates Somatic Hypermutation at A . T Base Pairs
[作者：Frieder, D; Larijani, M; Collins, C; Shulman, M; Martin, A,期刊：Molecular and Cellular Biology, 页码：5148-5157 , 文章类型： Article，,卷期：2009年29-18]
- Mismatch repair plays an essential role in reducing the cellular mutation load. Paradoxically, proteins in this pathway produce A . T mutations during the somatic hypermutation of immunoglobulin genes. Although recent ev...
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