- Hyperactivated NF-kappa B and AP-1 Transcription Factors Promote Highly Accessible Chromatin and Constitutive Transcription across the Interleukin-6 Gene Promoter in Metastatic Breast Cancer Cells
[作者:Ndlovu, MN; Van Lint, C; Van Wesemael, K; Callebert, P; Chalbos, D; Haegeman, G; Vanden Berghe, W,期刊:Molecular and Cellular Biology, 页码:5488-5504 , 文章类型: Article,,卷期:2009年29-20]
- Interleukin-6 (IL-6), involved in cancer-related inflammation, acts as an autocrine and paracrine growth factor, which promotes angiogenesis, metastasis, and subversion of immunity, and changes the response to hormones a...
- Nuclear-Cytoplasmic Shuttling of Menin Regulates Nuclear Translocation of beta-Catenin
[作者:Cao, YA; Liu, RX; Jiang, XL; Lu, JL; Jiang, JJ; Zhang, CX; Li, XY; Ning, G,期刊:Molecular and Cellular Biology, 页码:5477-5487 , 文章类型: Article,,卷期:2009年29-20]
- Menin, which is encoded by the multiple endocrine neoplasia type 1 (MEN1) gene, is a tumor suppressor and transcriptional regulator. Menin controls proliferation and apoptosis of cells, especially pancreatic beta cells. ...
- Dermatan Sulfate Epimerase 1-Deficient Mice Have Reduced Content and Changed Distribution of Iduronic Acids in Dermatan Sulfate and an Altered Collagen Structure in Skin
[作者:Maccarana, M; Kalamajski, S; Kongsgaard, M; Magnusson, SP; Oldberg, A; Malmstrom, A,期刊:Molecular and Cellular Biology, 页码:5517-5528 , 文章类型: Article,,卷期:2009年29-20]
- Dermatan sulfate epimerase 1 (DS-epi1) and DS-epi2 convert glucuronic acid to iduronic acid in chondroitin/dermatan sulfate biosynthesis. Here we report on the generation of DS-epi1-null mice and the resulting alteration...
- Pex2 and Pex12 Function as Protein-Ubiquitin Ligases in Peroxisomal Protein Import
[作者:Platta, HW; El Magraoui, F; Baumer, BE; Schlee, D; Girzalsky, W; Erdmann, R,期刊:Molecular and Cellular Biology, 页码:5505-5516 , 文章类型: Article,,卷期:2009年29-20]
- The PTS1-dependent peroxisomal matrix protein import is facilitated by the receptor protein Pex5 and can be divided into cargo recognition in the cytosol, membrane docking of the cargo-receptor complex, cargo release, an...
- A Role for Polypyrimidine Tract Binding Protein in the Establishment of Focal Adhesions
[作者:Babic, I; Sharma, S; Black, DL,期刊:Molecular and Cellular Biology, 页码:5564-5577 , 文章类型: Article,,卷期:2009年29-20]
- Polypyrimidine tract binding protein (PTB) is a widely expressed RNA binding protein. In the nucleus PTB regulates the splicing of alternative exons, while in the cytoplasm it can affect mRNA stability, translation, and ...
- TAK1-Mediated Serine/Threonine Phosphorylation of Epidermal Growth Factor Receptor via p38/Extracellular Signal-Regulated Kinase: NF-kappa B-Independent Survival Pathways in Tumor Necrosis Factor Alpha Signaling
[作者:Nishimura, M; Shin, MS; Singhirunnusorn, P; Suzuki, S; Kawanishi, M; Koizumi, K; Saiki, I; Sakurai, H,期刊:Molecular and Cellular Biology, 页码:5529-5539 , 文章类型: Article,,卷期:2009年29-20]
- The kinase TAK1, a mitogen-activated protein kinase kinase kinase (MAP3K),has been widely accepted as a key kinase activating NF-kappa B and MAPKs in tumor necrosis factor alpha (TNF-alpha) signaling. We have recently re...
- Drosophila Suppressor of Sable Protein [Su(s)] Promotes Degradation of Aberrant and Transposon-Derived RNAs
[作者:Kuan, YS; Brewer-Jensen, P; Bai, WL; Hunter, C; Wilson, CB; Bass, S; Abernethy, J; Wing, JS; Searles, LL,期刊:Molecular and Cellular Biology, 页码:5590-5603 , 文章类型: Article,,卷期:2009年29-20]
- RNA-binding proteins act at various stages of gene expression to regulate and fine-tune patterns of mRNA accumulation. One protein in this class is Drosophila Su(s), a nuclear protein that has been previously shown to in...
- The Adapter Protein SLP-76 Mediates "Outside-In" Integrin Signaling and Function in T Cells
[作者:Baker, RG; Hsu, CJ; Lee, D; Jordan, MS; Maltzman, JS; Hammer, DA; Baumgart, T; Koretzky, GA,期刊:Molecular and Cellular Biology, 页码:5578-5589 , 文章类型: Article,,卷期:2009年29-20]
- The adapter protein SH2 domain-containing leukocyte protein of 76 kDa (SLP-76) is an essential mediator of signaling from the T-cell antigen receptor (TCR). We report here that SLP-76 also mediates signaling downstream o...
- Coupled RNA Processing and Transcription of Intergenic Primary MicroRNAs
[作者:Ballarino, M; Pagano, F; Girardi, E; Morlando, M; Cacchiarelli, D; Marchioni, M; Proudfoot, NJ; Bozzoni, I,期刊:Molecular and Cellular Biology, 页码:5632-5638 , 文章类型: Article,,卷期:2009年29-20]
- The first step in microRNA (miRNA) biogenesis occurs in the nucleus and is mediated by the Microprocessor complex containing the RNase III-like enzyme Drosha and its cofactor DGCR8. Here we show that the 5'-->3' exonucle...
- HMGA1 Levels Influence Mitochondrial Function and Mitochondrial DNA Repair Efficiency
[作者:Mao, L; Wertzler, KJ; Maloney, SC; Wang, ZP; Magnuson, NS; Reeves, R,期刊:Molecular and Cellular Biology, 页码:5426-5440 , 文章类型: Review,,卷期:2009年29-20]
- HMGA chromatin proteins, a family of gene regulatory factors found at only low concentrations in normal cells, are almost universally overexpressed in cancer cells. HMGA proteins are located in the nuclei of normal cells...
- Chromatin Architecture and Transcription Factor Binding Regulate Expression of Erythrocyte Membrane Protein Genes
[作者:Steiner, LA; Maksimova, Y; Schulz, V; Wong, C; Raha, D; Mahajan, MC; Weissman, SM; Gallagher, PG,期刊:Molecular and Cellular Biology, 页码:5399-5412 , 文章类型: Review,,卷期:2009年29-20]
- Erythrocyte membrane protein genes serve as excellent models of complex gene locus structure and function, but their study has been complicated by both their large size and their complexity. To begin to understand the in...
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