- Weight loss and lipolysis promote a dynamic immune response in murine adipose tissue
[作者:Kosteli, A; Sugaru, E; Haemmerle, G; Martin, JF; Lei, J; Zechner, R; Ferrante, AW,期刊:Journal of clinical investigation, 页码:3466-3479 , 文章类型: Article,,卷期:2010年120-10]
- Obesity elicits an immune response characterized by myeloid cell recruitment to key metabolic organs, including adipose tissue. However, the response of immune cells to nonpathologic metabolic stimuli has been less well ...
- Inhibition of TRPC6 degradation suppresses ischemic brain damage in rats
[作者:Du, WL; Huang, JB; Yao, HL; Zhou, KC; Duan, B; Wang, YZ,期刊:Journal of clinical investigation, 页码:3480-3492 , 文章类型: Article,,卷期:2010年120-10]
- Brain injury after focal cerebral ischemia, the most common cause of stroke, develops from a series of pathological processes, including excitotoxicity, inflammation, and apoptosis. While NMDA receptors have been implica...
- Integration of a Notch-dependent mesenchymal gene program and Bmp2-driven cell invasiveness regulates murine cardiac valve formation
[作者:Luna-Zurita, L; Prados, B; Grego-Bessa, J; Luxan, G; del Monte, G; Benguria, A; Adams, RH; Perez-Pomares, JM; de la Pompa, JL,期刊:Journal of clinical investigation, 页码:3493-3507 , 文章类型: Article,,卷期:2010年120-10]
- Cardiac valve formation is crucial for embryonic and adult heart function. Valve malformations constitute the most common congenital cardiac defect, but little is known about the molecular mechanisms regulating valve for...
- A beta(IV)-spectrin/CaMKII signaling complex is essential for membrane excitability in mice
[作者:Hund, TJ; Koval, OM; Li, JD; Wright, PJ; Dian, L; Snyder, JS; Gudmundsson, H; Kline, CF; Davidson, NP; Cardona, N; Rasband, MN; Anderson, ME; Mohler, PJ,期刊:Journal of clinical investigation, 页码:3508-3519 , 文章类型: Article,,卷期:2010年120-10]
- Ion channel function is fundamental to the existence of Life. In metazoans, the coordinate activities of voltage-gated Na+ channels underlie cellular excitability and control neuronal communication, cardiac excitation-co...
- Cardiac fibrosis in mice with hypertrophic cardiomyopathy is mediated by non-myocyte proliferation and requires Tgf-beta
[作者:Teekakirikul, P; Eminaga, S; Toka, O; Alcalai, R; Wang, LB; Wakimoto, H; Nayor, M; Konno, T; Gorham, JM; Wolf, CM; Kim, JB; Schmitt, JP; Molkentin, JD; Norris, RA; Tager, AM; Hoffman, SR; Markwald, RR; Seidman, CE; Seidman, JG,期刊:Journal of clinical investigation, 页码:3520-3529 , 文章类型: Article,,卷期:2010年120-10]
- Mutations in sarcomere protein genes can cause hypertrophic cardiomyopathy (HCM), a disorder characterized by myocyte enlargement, fibrosis, and impaired ventricular relaxation. Here, we demonstrate that sarcomere protei...
- Human parvovirus B19 causes cell cycle arrest of human erythroid progenitors via deregulation of the E2F family of transcription factors
[作者:Wan, ZH; Zhi, N; Wong, SS; Keyvanfar, K; Liu, DL; Raghavachari, N; Munson, PJ; Su, S; Malide, D; Kajigaya, S; Young, NS,期刊:Journal of clinical investigation, 页码:3530-3544 , 文章类型: Article,,卷期:2010年120-10]
- Human parvovirus B19 (B19V) is the only human pathogenic parvovirus. It causes a wide spectrum of human diseases, including fifth disease (erythema infectiosum) in children and pure red cell aplasia in immunocompromised ...
- Proapoptotic Rassf1A/Mst1 signaling in cardiac fibroblasts is protective against pressure overload in mice
[作者:Del Re, DP; Matsuda, T; Zhai, PY; Gao, SM; Clark, GJ; Van Der Weyden, L; Sadoshima, J,期刊:Journal of clinical investigation, 页码:3555-3567 , 文章类型: Article,,卷期:2010年120-10]
- Mammalian sterile 20-like kinase 1 (Mst1) is a mammalian homolog of Drosophila Hippo, the master regulator of cell death, proliferation, and organ size in flies. It is the chief component of the mammalian Hippo pathway a...
- Neuroretina specification in mouse embryos requires S1x3-mediated suppression of Wnt8b in the anterior neural plate
[作者:Liu, W; Lagutin, O; Swindell, E; Jamrich, M; Oliver, G,期刊:Journal of clinical investigation, 页码:3568-3577 , 文章类型: Article,,卷期:2010年120-10]
- Retinal degeneration causes vision impairment and blindness in humans. If one day we are to harness the potential of stem cell-based cell replacement therapies to treat these conditions, it is imperative that we better u...
- HSP90 is a therapeutic target in JAK2-dependent myeloproliferative neoplasms in mice and humans
[作者:Marubayashi, S; Koppikar, P; Taldone, T; Abdel-Wahab, O; West, N; Bhagwat, N; Caldas-Lopes, E; Ross, KN; Gonen, M; Gozman, A; Ahn, JH; Rodina, A; Ouerfelli, O; Yang, GB; Hedvat, C; Bradner, JE; Chiosis, G; Levine, RL,期刊:Journal of clinical investigation, 页码:3578-3593 , 文章类型: Article,,卷期:2010年120-10]
- JAK2 kinase inhibitors were developed for the treatment of myeloproliferative neoplasms (MPNs), following the discovery of activating JAK2 mutations in the majority of patients with MPN. However, to date JAK2 inhibitor t...
- Cytoplasmic p21 expression levels determine cisplatin resistance in human testicular cancer
[作者:Koster, R; di Pietro, A; Timmer-Bosscha, H; Gibcus, JH; van den Berg, A; Suurmeijer, AJ; Bischoff, R; Gietema, JA; de Jong, S,期刊:Journal of clinical investigation, 页码:3594-3605 , 文章类型: Article,,卷期:2010年120-10]
- Platinum-based chemotherapies such as cisplatin are used as first-line treatment for many cancers. Although there is often a high initial responsiveness, the majority of patients eventually relapse with platinum-resistan...
- HGF upregulation contributes to angiogenesis in mice with keratinocyte-specific Smad2 deletion
[作者:Hoot, KE; Oka, M; Han, GW; Bottinger, E; Zhang, QH; Wang, XJ,期刊:Journal of clinical investigation, 页码:3606-3616 , 文章类型: Article,,卷期:2010年120-10]
- TGF-beta signaling can promote tumor formation and development or suppress it, depending on the cellular context and tumor stage. A potential target of this dual effect of TGF-beta is HGF, as TGF-beta can inhibit or prom...
- Failure to ubiquitinate c-Met leads to hyperactivation of mTOR signaling in a mouse model of autosomal dominant polycystic kidney disease
[作者:Qin, SA; Taglienti, M; Nauli, SM; Contrino, L; Takakura, A; Zhou, J; Kreidberg, JA,期刊:Journal of clinical investigation, 页码:3617-3628 , 文章类型: Article,,卷期:2010年120-10]
- Autosomal dominant polycystic kidney disease (ADPKD) is a common inherited disorder that is caused by mutations at two loci, polycystin 1 (PKD1) and polycystin 2 (PKD2). It is characterized by the formation of multiple c...
- Therapeutic Treg expansion in mice by TNFRSF25 prevents allergic lung inflammation
[作者:Schreiber, TH; Wolf, D; Tsai, MS; Chirinos, J; Deyev, VV; Gonzalez, L; Malek, TR; Levy, RB; Podack, ER,期刊:Journal of clinical investigation, 页码:3629-3640 , 文章类型: Article,,卷期:2010年120-10]
- TNF receptor superfamily member 25 (TNFRSF25; also known as DR3, and referred to herein as TNFR25) is constitutively and highly expressed by CD4(+)FoxP3(+) Tregs. However, its function on these cells has not been determi...
- HLA-E restricted regulatory CD8(+) T cells are involved in development and control of human autoimmune type 1 diabetes
[作者:Jiang, H; Canfield, SM; Gallagher, MP; Jiang, HH; Jiang, YH; Zheng, ZY; Chess, L,期刊:Journal of clinical investigation, 页码:3641-3650 , 文章类型: Article,,卷期:2010年120-10]
- A key feature of the immune system is its ability to discriminate self from nonself. Breakdown in any of the mechanisms that maintain unresponsiveness to self (a state known as self-tolerance) contributes to the developm...
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