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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共8条记录   CUSTIRSEN SODIUM Clusterin-Targeting Antisense Therapy Oncolytic [作者：Chi, KN; Gleave, ME,期刊：Drugs of the Future, 页码：525-530 , 文章类型： Article，,卷期：2009年34-7] Clusterin is a stress-induced cytoprotective chaperone protein that functions similarly to a small heat shock protein. Clusterin is expressed in a variety of cancers and associated with broad-spectrum treatment resistanc... TMC-435350 HCV NS3/4A Protease Inhibitor Anti-Hepatitis C Virus Drug [作者：Davies, S,期刊：Drugs of the Future, 页码：545-553 , 文章类型： Article，,卷期：2009年34-7] Hepatitis C is a viral infection of the liver and a major cause of acute hepatitis and chronic liver disease, including cirrhosis and liver cancer. Despite programs to control the spread of the hepatitis C virus (HCV), 3... HEPLISAV (TM) Hepatitis B Vaccine [作者：Madaan, A,期刊：Drugs of the Future, 页码：531-535 , 文章类型： Article，,卷期：2009年34-7] Universal immunization against hepatitis B virus (HBV) is an effective strategy to reduce the global morbidity and mortality burden of HBV disease. However, with the three-dose series of the current commercial HBV vaccin... NAPROXCINOD Nonsteroidal Anti-Inflammatory Agent Cyclooxygenase-Inhibiting NO Donor [作者：Fiorucci, S,期刊：Drugs of the Future, 页码：537-543 , 文章类型： Article，,卷期：2009年34-7] Naproxcinod (naproxen nitroxybutyl ester, nitronaproxen, NO-naproxen) is a nitric oxide (NO) derivative of the nonsteroidal anti-inflammatory drug (NSAID) naproxen. Naproxcinod is the first of a class of NSAIDs known as ... INHIBITORS OF 17-beta-HYDROXYSTEROID DEHYDROGENASE TYPE 3 (17-beta-HSD 3) [作者：Olusanjo, MS; Ahmed, S,期刊：Drugs of the Future, 页码：555-563 , 文章类型： Review，,卷期：2009年34-7] The specific conversion of androstenedione to testosterone is catalyzed by 17-beta-hydroxysteroid dehydrogenose type 3 (17-beta-HSD 3), on enzyme which has been shown to be localized in the microsomal fraction of the Ley... THE MEDITERRANEAN DIET, PART II: RED WINE AND CARDIOVASCULAR DISEASE - MORE FACTS, LESS FANCY [作者：Pouwels, EKJ; Kostkiewicz, M,期刊：Drugs of the Future, 页码：565-574 , 文章类型： Review，,卷期：2009年34-7] The Western-type diet, rich in saturated fats and low in fish and vegetables, has been associated with a high incidence of cardiovascular disease due to its proinflammatory, pro-oxidative and prothrombotic properties. In... INHERITED EPIDERMOLYSIS BULLOSA [作者：Davies, S,期刊：Drugs of the Future, 页码：575-578 , 文章类型： Article，,卷期：2009年34-7] Inherited epidermolysis bullosa (EB) is characterized by a lack of anchoring filaments that facilitate adhesion of the epidermal and dermal layers of the skin. This results in significant blister or sore formation in res... SOLUBLE EPOXIDE HYDROLASE AS A THERAPEUTIC TARGET FOR CARDIOVASCULAR DISEASES [作者：Fang, X; Singh, P; Smith, RG,期刊：Drugs of the Future, 页码：579-585 , 文章类型： Article，,卷期：2009年34-7] Arachidonic acid is metabolized to epoxyeicosatrienoic acids (EETs) by cytochrome P450 epoxygenase. Four EET regioisomers, 5,6-, 8,9-, 77,12-and 74,15-EETs, are formed depending on the location of the epoxy group. EETs c...