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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共9条记录   BAFETINIB Dual BCR/ABL and Lyn Tyrosine Kinase Inhibitor Treatment of Chronic Myeloid Leukemia [作者：Takeuchi, M; Kimura, S; Ashihara, E; Maekawa, T,期刊：Drugs of the Future, 页码：261-269 , 文章类型： Article，,卷期：2009年34-4] The treatment of chronic myeloid leukemia (CML) has changed dramatically with the emergence of the ABL tyrosine kinase inhibitor (TKI) imatinib mesilate However, primary and secondary imatinib resistance has been frequen... MKC-1 Antimitotic agent Apoptosis inducer Oncolytic [作者：Dulsat, C; Castaner, R; Bolos, J,期刊：Drugs of the Future, 页码：270-275 , 文章类型： Article，,卷期：2009年34-4] MKC-1 (formerly known as Ro-31-7453) Is a novel, orally active cell cycle inhibitor with broad-spectrum antitumor effects, including multidrug-resistant cell lines Preclinical investigations hove shown that MKC-1 produce... NKO12 Topoisomerase I Inhibitor Apoptosis Inducer Oncolytic Matsumura [作者：Matsumura, Y,期刊：Drugs of the Future, 页码：276-281 , 文章类型： Article，,卷期：2009年34-4] Selective tumor targeting by therapeutic agents is a long-standing pharmacological goal to improve selectivity and therapeutic indices Mast scientists have sought to use active receptor-mediated tumor-targeting systems, ... INHIBITORS OF SODIUM/GLUCOSE COTRANSPORT [作者：Borghese, MFA; Majowicz, MP,期刊：Drugs of the Future, 页码：297-305 , 文章类型： Review，,卷期：2009年34-4] Sodium/glucose cotransporters (SGLTs) belong to the solute corner family 5 (SLC5), which has more than 200 members in animal and bacterial cells This gene family was originally thought to contain only 11 members of the h... R-7128 RNA-Directed RNA Polymerise (NS5B) Inhibitor Treatment of Hepatitis C Virus Infection [作者：Cole, P; Castaner, R; Bolos, J,期刊：Drugs of the Future, 页码：282-290 , 文章类型： Article，,卷期：2009年34-4] Hepatitis C virus (HCV) Infection is almost certainly more widespread than is commonly thought, and chronic disease can be severely debilitating The standard treatment, the combination of pegylated Interferon alfa and ri... RESVERATROL/SRT501 Sirtuin SIRT1 Activator Treatment of Type 2 Diabetes [作者：Elliott, PJ; Walpole, SM; Morelli, L; Lambert, PD; Lunsmann, W; Westphal, CH; Lavu, S,期刊：Drugs of the Future, 页码：291-295 , 文章类型： Article，,卷期：2009年34-4] The consumption of resveratrol, a naturally occurring polyphenol found in foods, has been associated with possible health benefits. These benefits are derived, in part, from activation of NAD-dependent deacetylase sirtui... THE MEDITERRANEAN DIET, PART I: THE ANTICANCER EFFECT OF OLIVE OIL [作者：Pauwels, EKJ; Covas, MI,期刊：Drugs of the Future, 页码：307-313 , 文章类型： Review，,卷期：2009年34-4] For good scientific reasons it has been argued that the Mediterranean diet has beneficial anticarcinogenic effects, evidenced by a relatively long cancer-free survival Olive oil plays an important culinary role in the di... CURRENT STATUS OF DRUG THERAPY DEVELOPMENT FOR NIEMANN-PICK TYPE C DISEASE [作者：Helquist, P; Wiest, O,期刊：Drugs of the Future, 页码：315-331 , 文章类型： Article，,卷期：2009年34-4] Niemann-Pick type C (NPC) disease is a very rare, fatal disorder due to mutations in either of two different genes, NPC1 or NPC2, which are involved in intracellular lipid trafficking but for which the specific functions... SOLUBLE CD40 LIGAND IN DEMENTIA [作者：Giunta, B; Figueroa, KP; Town, T; Tan, J,期刊：Drugs of the Future, 页码：333-339 , 文章类型： Article，,卷期：2009年34-4] Some 15-20% of the population over the age of 65 years suffer horn dementia, currently one of the leading causes of death behind cardiovascular diseases, cancer and cerebrovascular diseases The major forms of dementia sh...