- MDM2 Mediates Ubiquitination and Degradation of Activating Transcription Factor 3
[作者:Mo, PL; Wang, HB; Lu, H; Boyd, DD; Yan, CH,期刊:Journal of Biological Chemistry, 页码:26908-26915 , 文章类型: Article,,卷期:2010年285-35]
- Activating transcription factor 3 (ATF3) is a common stress sensor, and its rapid induction by cellular stresses (e.g. DNA damage) is crucial for cells to mount appropriate responses (e.g. activating the tumor suppressor...
- Biophysical Investigations of Complement Receptor 2 (CD21 and CR2)-Ligand Interactions Reveal Amino Acid Contacts Unique to Each Receptor-Ligand Pair
[作者:Kovacs, JM; Hannan, JP; Eisenmesser, EZ; Holers, VM,期刊:Journal of Biological Chemistry, 页码:27251-27258 , 文章类型: Article,,卷期:2010年285-35]
- Human complement receptor type 2 (CR2 and CD21) is a cell membrane receptor, with 15 or 16 extracellular short consensus repeats (SCRs), that promotes B lymphocyte responses and bridges innate and acquired immunity. The ...
- The PRiMA-linked Cholinesterase Tetramers Are Assembled from Homodimers HYBRID MOLECULES COMPOSED OF ACETYLCHOLINESTERASE AND BUTYRYLCHOLINESTERASE DIMERS ARE UP-REGULATED DURING DEVELOPMENT OF CHICKEN BRAIN
[作者:Chen, VP; Xie, HQ; Chan, WKB; Leung, KW; Chan, GKL; Choi, RCY; Bon, S; Massoulie, J; Tsim, KWK,期刊:Journal of Biological Chemistry, 页码:27265-27278 , 文章类型: Article,,卷期:2010年285-35]
- Acetylcholinesterase (AChE) is anchored onto cell membranes by the transmembrane protein PRiMA (proline-rich membrane anchor) as a tetrameric globular form that is prominently expressed in vertebrate brain. In parallel, ...
- Mitotic Down-regulation of p190RhoGAP Is Required for the Successful Completion of Cytokinesis
[作者:Manchinelly, SAS; Miller, JA; Su, L; Miyake, T; Palmer, L; Mikawa, M; Parsons, SJ,期刊:Journal of Biological Chemistry, 页码:26923-26932 , 文章类型: Article,,卷期:2010年285-35]
- p190RhoGAP-A (p190) is a GTPase-activating protein known to regulate actin cytoskeleton dynamics by decreasing RhoGTP levels through activation of Rho intrinsic GTPase activity. We have previously shown that p190 protein...
- Retinoic Acid Induces Expression of the Thyroid Hormone Transporter, Monocarboxylate Transporter 8 (Mct8)
[作者:Kogai, T; Liu, YY; Richter, LL; Mody, K; Kagechika, H; Brent, GA,期刊:Journal of Biological Chemistry, 页码:27279-27288 , 文章类型: Article,,卷期:2010年285-35]
- Retinoic acid (RA) and thyroid hormone are critical for differentiation and organogenesis in the embryo. Mct8 (monocarboxylate transporter 8), expressed predominantly in the brain and placenta, mediates thyroid hormone u...
- Postendocytic Sorting of Constitutively Internalized Dopamine Transporter in Cell Lines and Dopaminergic Neurons
[作者:Eriksen, J; Bjorn-Yoshimoto, WE; Jorgensen, TN; Newman, AH; Gether, U,期刊:Journal of Biological Chemistry, 页码:27289-27301 , 文章类型: Article,,卷期:2010年285-35]
- The dopamine transporter (DAT) mediates reuptake of released dopamine and is the target for psychostimulants, such as cocaine and amphetamine. DAT undergoes marked constitutive endocytosis, but little is known about the ...
- Human Tau Isoforms Assemble into Ribbon-like Fibrils That Display Polymorphic Structure and Stability
[作者:Wegmann, S; Jung, YJ; Chinnathambi, S; Mandelkow, EM; Mandelkow, E; Muller, DJ,期刊:Journal of Biological Chemistry, 页码:27302-27313 , 文章类型: Article,,卷期:2010年285-35]
- Fibrous aggregates of Tau protein are characteristic features of Alzheimer disease. We applied high resolution atomic force and EM microscopy to study fibrils assembled from different human Tau isoforms and domains. All ...
- Airway Surface Liquid Volume Regulation Determines Different Airway Phenotypes in Liddle Compared with beta ENaC-overexpressing Mice
[作者:Mall, MA; Button, B; Johannesson, B; Zhou, Z; Livraghi, A; Caldwell, RA; Schubert, SC; Schultz, C; O'Neal, WK; Pradervand, S; Hummler, E; Rossier, BC; Grubb, BR; Boucher, RC,期刊:Journal of Biological Chemistry, 页码:26945-26955 , 文章类型: Article,,卷期:2010年285-35]
- Studies in cystic fibrosis patients and mice overexpressing the epithelial Na+ channel beta-subunit (beta ENaC-Tg) suggest that raised airway Na+ transport and airway surface liquid (ASL) depletion are central to the pat...
- The Yeast Mitochondrial Citrate Transport Protein MOLECULAR DETERMINANTS OF ITS SUBSTRATE SPECIFICITY
[作者:Aluvila, S; Kotaria, R; Sun, JK; Mayor, JA; Walters, DE; Harrison, DHT; Kaplan, RS,期刊:Journal of Biological Chemistry, 页码:27314-27326 , 文章类型: Article,,卷期:2010年285-35]
- The objective of this study was to identify the role of individual amino acid residues in determining the substrate specificity of the yeast mitochondrial citrate transport protein (CTP). Previously, we showed that the C...
- RIC-3 Exclusively Enhances the Surface Expression of Human Homomeric 5-Hydroxytryptamine Type 3A (5-HT(3)A) Receptors Despite Direct Interactions with 5-HT3A, -C, -D, and -E Subunits
[作者:Walstab, J; Hammer, C; Lasitschka, F; Moller, D; Connolly, CN; Rappold, G; Bruss, M; Bonish, H; Niesler, B,期刊:Journal of Biological Chemistry, 页码:26956-26965 , 文章类型: Article,,卷期:2010年285-35]
- Although five 5-hydroxytryptamine type 3 (5-HT3) subunits (A-E) have been cloned, knowledge on the regulation of their assembly is limited. RIC-3 has been identified as a chaperone specific for the pentameric ligand-gate...
- Interactions between Intracellular Domains as Key Determinants of the Quaternary Structure and Function of Receptor Heteromers
[作者:Navarro, G; Ferre, S; Cordomi, A; Moreno, E; Mallol, J; Casado, V; Cortes, A; Hoffmann, H; Ortiz, J; Canela, EI; Lluis, C; Pardo, L; Franco, R; Woods, AS,期刊:Journal of Biological Chemistry, 页码:27346-27359 , 文章类型: Article,,卷期:2010年285-35]
- G protein-coupled receptor (GPCR) heteromers are macromolecular complexes with unique functional properties different from those of its individual protomers. Little is known about what determines the quaternary structure...
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