- N-type Calcium Channel in the Pathogenesis of Experimental Autoimmune Encephalomyelitis
[作者:Tokuhara, N; Namiki, K; Uesugi, M; Miyamoto, C; Ohgoh, M; Ido, K; Yoshinaga, T; Yamauchi, T; Kuromitsu, J; Kimura, S; Miyamoto, N; Kasuya, Y,期刊:Journal of Biological Chemistry, 页码:33294-33306 , 文章类型: Article,,卷期:2010年285-43]
- One of the family of voltage-gated calcium channels (VGCC), the N-type Ca2+ channel, is located predominantly in neurons and is associated with a variety of neuronal responses, including neurodegeneration. A precise mech...
- Palmitoylation of the S0-S1 Linker Regulates Cell Surface Expression of Voltage- and Calcium-activated Potassium (BK) Channels
[作者:Jeffries, O; Geiger, N; Rowe, ICM; Tian, LJ; McClafferty, H; Chen, L; Bi, DL; Knaus, HG; Ruth, P; Shipston, MJ,期刊:Journal of Biological Chemistry, 页码:33307-33314 , 文章类型: Article,,卷期:2010年285-43]
- S-Palmitoylation is rapidly emerging as an important post-translational mechanism to regulate ion channels. We have previously demonstrated that large conductance calcium-and voltage-activated potassium (BK) channels are...
- Control of Activating Transcription Factor 4 (ATF4) Persistence by Multisite Phosphorylation Impacts Cell Cycle Progression and Neurogenesis
[作者:Frank, CL; Ge, XC; Xie, ZG; Zhou, Y; Tsai, LH,期刊:Journal of Biological Chemistry, 页码:33324-33337 , 文章类型: Article,,卷期:2010年285-43]
- Organogenesis is a highly integrated process with a fundamental requirement for precise cell cycle control. Mechanistically, the cell cycle is composed of transitions and thresholds that are controlled by coordinated pos...
- Porphyromonas gingivalis Peptidoglycans Induce Excessive Activation of the Innate Immune System in Silkworm Larvae
[作者:Ishii, K; Hamamoto, H; Imamura, K; Adachi, T; Shoji, M; Nakayama, K; Sekimizu, K,期刊:Journal of Biological Chemistry, 页码:33338-33347 , 文章类型: Article,,卷期:2010年285-43]
- Porphyromonas gingivalis, a pathogen that causes inflammation in human periodontal tissue, killed silkworm (Bombyx mori, Lepidoptera) larvae when injected into the blood (hemolymph). Silkworm lethality was not rescued by...
- Interdependent Phosphorylation within the Kinase Domain T-loop Regulates CHK2 Activity
[作者:Guo, X; Ward, MD; Tiedebohl, JB; Oden, YM; Nyalwidhe, JO; Semmes, OJ,期刊:Journal of Biological Chemistry, 页码:33348-33357 , 文章类型: Article,,卷期:2010年285-43]
- Chk2 is a critical regulator of the cellular DNA damage repair response. Activation of Chk2 in response to IR-induced damage is initiated by phosphorylation of the Chk2 SQ/TQ cluster domain at Ser(19), Ser(33), Ser(35), ...
- Editing of Epstein-Barr Virus-encoded BART6 MicroRNAs Controls Their Dicer Targeting and Consequently Affects Viral Latency
[作者:Lizasa, H; Wulff, BE; Alla, NR; Maragkakis, M; Megraw, M; Hatzigeorgiou, A; Iwakiri, D; Takada, K; Wiedmer, A; Showe, L; Lieberman, P; Nishikura, K,期刊:Journal of Biological Chemistry, 页码:33358-33370 , 文章类型: Article,,卷期:2010年285-43]
- Certain primary transcripts of miRNA (pri-microRNAs) undergo RNA editing that converts adenosine to inosine. The Epstein-Barr virus (EBV) genome encodes multiple microRNA genes of its own. Here we report that primary tra...
- Pax6 Controls the Expression of Critical Genes Involved in Pancreatic alpha Cell Differentiation and Function
[作者:Gosmain, Y; Marthinet, E; Cheyssac, C; Guerardel, A; Mamin, A; Katz, LS; Bouzakri, K; Philippe, J,期刊:Journal of Biological Chemistry, 页码:33381-33393 , 文章类型: Article,,卷期:2010年285-43]
The paired box homeodomain Pax6 is crucial for endocrine cell development and function and plays an essential role in glucose homeostasis. Indeed, mutations of Pax6 are associated with diabetic phenotype. Importantly,...
- Identification of the Matriptase Second CUB Domain as the Secondary Site for Interaction with Hepatocyte Growth Factor Activator Inhibitor Type-1
[作者:Inouye, K; Tsuzuki, S; Yasumoto, M; Kojima, K; Mochida, S; Fushiki, T,期刊:Journal of Biological Chemistry, 页码:33394-33403 , 文章类型: Article,,卷期:2010年285-43]
- Matriptase is a type II transmembrane serine protease comprising 855 amino acid residues. The extracellular region of matriptase comprises a noncatalytic stem domain (containing two tandem repeats of complement proteases...
- The Sodium Channel beta 3-Subunit Induces Multiphasic Gating in Na(v)1.3 and Affects Fast Inactivation via Distinct Intracellular Regions
[作者:Cusdin, FS; Nietlispach, D; Maman, J; Dale, TJ; Powell, AJ; Clare, JJ; Jackson, AP,期刊:Journal of Biological Chemistry, 页码:33404-33412 , 文章类型: Article,,卷期:2010年285-43]
- Electrical excitability in neurons depends on the activity of membrane-bound voltage gated sodium channels (Na-v) that are assembled from an ion conducting alpha-subunit and often auxiliary beta-subunits. The alpha-subun...
- Spectroscopic Studies of GSK3 beta Phosphorylation of the Neuronal Tau Protein and Its Interaction with the N-terminal Domain of Apolipoprotein E
[作者:Leroy, A; Landrieu, I; Huvent, I; Legrand, D; Codeville, B; Wieruszeski, JM; Lippens, G,期刊:Journal of Biological Chemistry, 页码:33435-33444 , 文章类型: Article,,卷期:2010年285-43]
- Alzheimer disease neurons are characterized by extraneuronal plaques formed by aggregated amyloid-beta peptide and by intraneuronal tangles composed of fibrillar aggregates of the microtubule-associated Tau protein. Tau ...
- Bi-specific MHC Heterodimers for Characterization of Cross-reactive T Cells
[作者:Shen, ZT; Brehm, MA; Daniels, KA; Sigalov, AB; Selin, LK; Welsh, RM; Stern, LJ,期刊:Journal of Biological Chemistry, 页码:33144-33153 , 文章类型: Article,,卷期:2010年285-43]
- T cell cross-reactivity describes the phenomenon whereby a single T cell can recognize two or more different peptide antigens presented in complex with MHC proteins. Cross-reactive T cells have previously been characteri...
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