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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共10条记录   Pharmacologists and Alzheimer disease therapy: to boldly go where no scientist has gone before [作者：Mancuso, C; Siciliano, R; Barone, E; Butterfield, DA; Preziosi, P,期刊：Expert opinion on investigational drugs, 页码：1243-1261 , 文章类型： Review，,卷期：2011年20-9] Introduction: Alzheimer disease (AD) is a progressive neurodegenerative disorder characterized by severe cognitive impairment, inability to perform activities of daily living and mood changes. Acetylcholinesterase inhibi... Inhibiting signal transducer and activator of transcription 3: rationality and rationale design of inhibitors [作者：Mankan, AK; Greten, FR,期刊：Expert opinion on investigational drugs, 页码：1263-1275 , 文章类型： Review，,卷期：2011年20-9] Introduction: Signal transducer and activator of transcription 3 (STAT3) controls a key signaling pathway in the development of many malignant diseases. Several genetic studies have proven its central role in the regulat... Targeting voltage-gated calcium channels for the treatment of neuropathic pain: a review of drug development [作者：Pexton, T; Moeller-Bertram, T; Schilling, JM; Wallace, MS,期刊：Expert opinion on investigational drugs, 页码：1277-1284 , 文章类型： Review，,卷期：2011年20-9] Introduction: Pain is a major burden for affected individuals and society, and controlling neuropathic pain is especially challenging. The number of drugs available is limited and treatments are often marginally effectiv... Discontinued drugs 2010: rheumatology, allergy and dermatology, pulmonary [作者：Antoniu, SA,期刊：Expert opinion on investigational drugs, 页码：1175-1187 , 文章类型： Article，,卷期：2011年20-9] This is the annual perspective paper on the discontinued drugs in the field of pulmonary disease allergy, rheumatology, and dermatology. It is part of series of papers discussing drugs dropped from clinical development i... Crotamine toxicity and efficacy in mouse models of melanoma [作者：Pereira, A; Kerkis, A; Hayashi, MAF; Pereira, ASP; Silva, FS; Oliveira, EB; da Silva, ARBP; Yamane, T; Radis-Baptista, G; Kerkis, I,期刊：Expert opinion on investigational drugs, 页码：1189-1200 , 文章类型： Article，,卷期：2011年20-9] Objectives: Selective anticancer cell activity for both cell-penetrating and cationic antimicrobial peptides has previously been reported. As crotamine possesses activities similar to both of these, this study investigat... Migraine prophylactic drugs - something new under the sun? [作者：Bekkelund, SI; Alstadhaug, KB,期刊：Expert opinion on investigational drugs, 页码：1201-1210 , 文章类型： Review，,卷期：2011年20-9] Introduction: The development of preventive treatments for migraine has lagged behind, in part because of limited knowledge about the primum movens of attacks.Areas covered: We aimed to make a status report about newer p... Serotonin 2A receptor antagonists for treatment of schizophrenia [作者：Ebdrup, BH; Rasmussen, H; Arnt, J; Glenthoj, B,期刊：Expert opinion on investigational drugs, 页码：1211-1223 , 文章类型： Review，,卷期：2011年20-9] Introduction: All approved antipsychotic drugs share an affinity for the dopamine 2 (D(2)) receptor; however, these drugs only partially ameliorate the symptoms of schizophrenia. It is, therefore, of paramount importance... Development of c-MET pathway inhibitors [作者：Liu, XD; Newton, RC; Scherle, PA,期刊：Expert opinion on investigational drugs, 页码：1225-1241 , 文章类型： Review，,卷期：2011年20-9] Introduction: The aberrantly upregulated c-mesenchymal-epithelia transition factor (c-MET) signaling pathway has been considered to be an attractive target for cancer intervention owing to the important roles it plays in... New drugs for cystic fibrosis [作者：Wilschanski, M; Kerem, E,期刊：Expert opinion on investigational drugs, 页码：1285-1292 , 文章类型： Review，,卷期：2011年20-9] Introduction: Cystic fibrosis (CF) is the most common lethal monogenic disorder. Life expectancy is rising towards a mean of 40 years, with advances in all aspects of therapy apart from treating the basic defect. Since t... Targeting the insulin-like growth factor signaling pathway: figitumumab and other novel anticancer strategies [作者：Yap, TA; Olmos, D; Molife, LR; de Bono, JS,期刊：Expert opinion on investigational drugs, 页码：1293-1304 , 文章类型： Editorial Material，,卷期：2011年20-9] Introduction: There are clear preclinical data that support the involvement of the insulin-like growth factor (IGF) signaling pathway in oncogenesis and cancer progression. Such evidence has led to the design and conduct...