- Forecasting Fire Season Severity in South America Using Sea Surface Temperature Anomalies
[作者:Chen, Y; Randerson, JT; Morton, DC; DeFries, RS; Collatz, GJ; Kasibhatla, PS; Giglio, L; Jin, YF; Marlier, ME,期刊:Science, 页码:787-791 , 文章类型: Article,,卷期:2011年334-6057]
- Fires in South America cause forest degradation and contribute to carbon emissions associated with land use change. We investigated the relationship between year-to-year changes in fire activity in South America and sea ...
- Recent Synchronous Radiation of a Living Fossil
[作者:Nagalingum, NS; Marshall, CR; Quental, TB; Rai, HS; Little, DP; Mathews, S,期刊:Science, 页码:796-799 , 文章类型: Article,,卷期:2011年334-6057]
- Modern survivors of previously more diverse lineages are regarded as living fossils, particularly when characterized by morphological stasis. Cycads are often cited as a classic example, reaching their greatest diversity...
- Global DNA Demethylation During Mouse Erythropoiesis in Vivo
[作者:Shearstone, JR; Pop, R; Bock, C; Boyle, P; Meissner, A; Socolovsky, M,期刊:Science, 页码:799-802 , 文章类型: Article,,卷期:2011年334-6057]
- In the mammalian genome, 5'-CpG-3' dinucleotides are frequently methylated, correlating with transcriptional silencing. Genome-wide demethylation is thought to occur only twice during development, in primordial germ cell...
- Influence of Inositol Pyrophosphates on Cellular Energy Dynamics
[作者:Szijgyarto, Z; Garedew, A; Azevedo, C; Saiardi, A,期刊:Science, 页码:802-805 , 文章类型: Article,,卷期:2011年334-6057]
- With its high-energy phosphate bonds, adenosine triphosphate (ATP) is the main intracellular energy carrier. It also functions in most signaling pathways, as a phosphate donor or a precursor for cyclic adenosine monophos...
- Sirt5 Is a NAD-Dependent Protein Lysine Demalonylase and Desuccinylase
[作者:Du, JT; Zhou, YY; Su, XY; Yu, JJ; Khan, S; Jiang, H; Kim, J; Woo, J; Kim, JH; Choi, BH; He, B; Chen, W; Zhang, S; Cerione, RA; Auwerx, J; Hao, Q; Lin, HN,期刊:Science, 页码:806-809 , 文章类型: Article,,卷期:2011年334-6057]
- Silent information regulator 2 (Sir2) proteins (sirtuins) are nicotinamide adenine dinucleotide-dependent deacetylases that regulate important biological processes. Mammals have seven sirtuins, Sirt1 to Sirt7. Four of th...
- Endocannabinoid Hydrolysis Generates Brain Prostaglandins That Promote Neuroinflammation
[作者:Nomura, DK; Morrison, BE; Blankman, JL; Long, JZ; Kinsey, SG; Marcondes, MCG; Ward, AM; Hahn, YK; Lichtman, AH; Conti, B; Cravatt, BF,期刊:Science, 页码:809-813 , 文章类型: Article,,卷期:2011年334-6057]
- Phospholipase A(2)(PLA(2)) enzymes are considered the primary source of arachidonic acid for cyclooxygenase (COX)-mediated biosynthesis of prostaglandins. Here, we show that a distinct pathway exists in brain, where mono...
- Failure to Confirm XMRV/MLVs in the Blood of Patients with Chronic Fatigue Syndrome: A Multi-Laboratory Study
[作者:Simmons, G; Glynn, SA; Komaroff, AL; Mikovits, JA; Tobler, LH; Hackett, J; Tang, N; Switzer, WM; Heneine, W; Hewlett, IK; Zhao, JQ; Lo, SC; Alter, HJ; Linnen, JM; Gao, K; Coffin, JM; Kearney, MF; Ruscetti, FW; Pfost, MA; Bethel, J; Kleinman, S; Holmberg, JA; Busch, MP,期刊:Science, 页码:814-817 , 文章类型: Article,,卷期:2011年334-6057]
- Murine leukemia viruses (MLVs), including xenotropic-MLV-related virus (XMRV), have been controversially linked to chronic fatigue syndrome (CFS). To explore this issue in greater depth, we compiled coded replicate sampl...
- tRNAs Marked with CCACCA Are Targeted for Degradation
[作者:Wilusz, JE; Whipple, JM; Phizicky, EM; Sharp, PA,期刊:Science, 页码:817-821 , 文章类型: Article,,卷期:2011年334-6057]
- The CCA-adding enzyme [ATP(CTP): tRNA nucleotidyltransferase] adds CCA to the 3' ends of transfer RNAs (tRNAs), a critical step in tRNA biogenesis that generates the amino acid attachment site. We found that the CCA-addi...
- A Burkholderia pseudomallei Toxin Inhibits Helicase Activity of Translation Factor eIF4A
[作者:Cruz-Migoni, A; Hautbergue, GM; Artymiuk, PJ; Baker, PJ; Bokori-Brown, M; Chang, CT; Dickman, MJ; Essex-Lopresti, A; Harding, SV; Mahadi, NM; Marshall, LE; Mobbs, GW; Mohamed, R; Nathan, S; Ngugi, SA; Ong, C; Ooi, WF; Partridge, LJ; Phillips, HL; Raih, MF; Ruzheinikov, S; Sarkar-Tyson, M; Sedelnikova, SE; Smither, SJ; Tan, P; Titball, RW; Wilson, SA; Rice, DW,期刊:Science, 页码:821-824 , 文章类型: Article,,卷期:2011年334-6057]
- The structure of BPSL1549, a protein of unknown function from Burkholderia pseudomallei, reveals a similarity to Escherichia coli cytotoxic necrotizing factor 1. We found that BPSL1549 acted as a potent cytotoxin against...
- Late Interleukin-6 Escalates T Follicular Helper Cell Responses and Controls a Chronic Viral Infection
[作者:Harker, JA; Lewis, GM; Mack, L; Zuniga, EI,期刊:Science, 页码:825-829 , 文章类型: Article,,卷期:2011年334-6057]
- Multiple inhibitory molecules create a profoundly immunuosuppressive environment during chronic viral infections in humans and mice. Therefore, eliciting effective immunity in this context represents a challenge. Here, w...
- Attention But Not Awareness Modulates the BOLD Signal in the Human V1 During Binocular Suppression
[作者:Watanabe, M; Cheng, K; Murayama, Y; Ueno, K; Asamizuya, T; Tanaka, K; Logothetis, N,期刊:Science, 页码:829-831 , 文章类型: Article,,卷期:2011年334-6057]
- Although recent psychophysical studies indicate that visual awareness and top-down attention are two distinct processes, it is not clear how they are neurally dissociated in the visual system. Using a two-by-two factoria...
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