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  • A GBD uncovered: the FHOD1 N terminus is formin'
    [作者:Baarlink, C; Grosse, R,期刊:Structure, 页码:1287-1288 , 文章类型: Editorial Material,,卷期:2008年16-9]
  • In this issue, Schulte et al. (2008) present the structure of the N-terminal region of human Diaphanous-related formin FHOD1, providing new insights into the differential molecular mechanisms of formin regulation and act...
  • A SIR-tain acetyl complex is caught by a sulfur trap
    [作者:Sauve, AA,期刊:Structure, 页码:1289-1292 , 文章类型: Editorial Material,,卷期:2008年16-9]
  • In this issue, Hawse et al. (2008) provide additional insight into the mechanistic properties of sirtuin enzymes by describing the structure of a thio-imidate in the active site of Thermatoga maritima Sir2, which strengt...
  • RapA: Completing the transcription cycle?
    [作者:Nechaev, S; Severinov, K,期刊:Structure, 页码:1294-1295 , 文章类型: Editorial Material,,卷期:2008年16-9]
  • In this issue of Structure, Shaw et al. (2008) report a crystal structure of the Escherichia coli RapA protein, the only bacterial member of the SWI/SNF2 family (Lewis et al., 1992; Bork and Koonin, 1993). The structure ...
  • PACemakers of proteasome core particle assembly
    [作者:Ramos, PC; Dohmen, RJ,期刊:Structure, 页码:1296-1304 , 文章类型: Review,,卷期:2008年16-9]
  • The 26S proteasome mediates ubiquitin-dependent proteolysis in eukaryotic cells. A number of studies including very recent ones have revealed that assembly of its 20S catalytic core particle is an ordered process that in...
  • Accurate NMR structures through minimization of an extended hybrid energy
    [作者:Nilges, M; Bernard, A; Bardiaux, B; Malliavin, T; Habeck, M; Rieping, W,期刊:Structure, 页码:1305-1312 , 文章类型: Article,,卷期:2008年16-9]
  • The use of generous distance bounds has been the hallmark of NMR structure determination. However, bounds necessitate the estimation of data quality before the calculation, reduce the information content, introduce human...
  • Structure of IL-22 bound to its high-affinity IL-22R1 chain
    [作者:Jones, BC; Logsdon, NJ; Walter, MR,期刊:Structure, 页码:1333-1344 , 文章类型: Article,,卷期:2008年16-9]
  • IL-22 is an IL-10 family cytokine that initiates innate immune responses against bacterial pathogens and contributes to immune disease. IL-22 biological activity is initiated by binding to a cell-surface complex composed...
  • Structure and disassembly of filaments formed by the ESCRT-III subunit Vps24
    [作者:Ghazi-Tabatabai, S; Saksena, S; Short, JM; Pobbati, AV; Veprintsev, DB; Crowther, RA; Emr, SD; Egelman, EH; Williams, RL,期刊:Structure, 页码:1345-1356 , 文章类型: Article,,卷期:2008年16-9]
  • The ESCRT machinery mediates sorting of ubiquitinated transmembrane proteins to lysosomes via multivesicular bodies (MVBs) and also has roles in cytokinesis and viral budding. The ESCRT-III subunits are metastable monome...
  • Structural insights into intermediate steps in the Sir2 deacetylation reaction
    [作者:Hawse, WF; Hoff, KG; Fatkins, DG; Daines, A; Zubkova, OV; Schramm, VL; Zheng, W; Wolberger, C,期刊:Structure, 页码:1368-1377 , 文章类型: Article,,卷期:2008年16-9]
  • Sirtuin enzymes comprise a unique class of NAD(+)-dependent protein deacetylases. Although structures of many sirtuin complexes have been determined, structural resolution of intermediate chemical steps are needed to und...