- Protein Metamorphosis: The Two-State Behavior of Mad2
[作者：Luo, XL; Yu, HT,期刊：Structure, 页码：1616-1625 , 文章类型： Review，,卷期：2008年16-11]
- A given protein generally has only one native tertiary fold, which is the conformation with the lowest Gibbs free energy. Mad2, a protein involved in the spindle checkpoint, however, has two natively folded states with s...
- Structural Basis for Parasite-Specific Functions of the Divergent Profilin of Plasmodium falciparum
[作者：Kursula, I; Kursula, P; Ganter, M; Panjikar, S; Matuschewski, K; Schuler, H,期刊：Structure, 页码：1638-1648 , 文章类型： Article，,卷期：2008年16-11]
- Profilins are key regulators of actin dynamics. They sequester actin monomers, forming a pool for rapid polymer formation stimulated by proteins such as formins. Apicomplexan parasites utilize a highly specialized microf...
- Core Structure of the Yeast Spt4-Spt5 Complex: A Conserved Module for Regulation of Transcription Elongation
[作者：Guo, M; Xu, F; Yamada, J; Egelhofer, T; Gao, YX; Hartzog, GA; Teng, MK; Niu, LW,期刊：Structure, 页码：1649-1658 , 文章类型： Article，,卷期：2008年16-11]
- The Spt4-Spt5 complex is an essential RNA polymerase II elongation factor found in all eukaryotes and important for gene regulation. We report here the crystal structure of Saccharomyces cerevisiae Spt4 bound to the NGN ...
- Genome Pool Strategy for Structural Coverage of Protein Families
[作者：Jaroszewski, L; Slabinski, L; Wooley, J; Deacon, AM; Lesley, SA; Wilson, IA; Godzik, A,期刊：Structure, 页码：1659-1667 , 文章类型： Article，,卷期：2008年16-11]
- Even closely homologous proteins often have different crystallization properties and propensities. This observation can be used to introduce an additional dimension into crystallization trials by simultaneous targeting m...
- Discovery of a Dipeptide Epimerase Enzymatic Function Guided by Homology Modeling and Virtual Screening
[作者：Kalyanaraman, C; Imker, HJ; Fedorov, AA; Fedorov, EV; Glasner, ME; Babbitt, PC; Almo, SC; Gerlt, JA; Jacobson, MP,期刊：Structure, 页码：1668-1677 , 文章类型： Article，,卷期：2008年16-11]
- We have developed a computational approach to aid the assignment of enzymatic function for uncharacterized proteins that uses homology modeling to predict the structure of the binding site and in silico docking to identi...
- Mechanism for Coordinated RNA Packaging and Genome Replication by Rotavirus Polymerase VP1
[作者：Lu, X; McDonald, SM; Tortorici, MA; Tao, YJ; Carpio, RVD; Nibert, ML; Patton, JT; Harrison, SC,期刊：Structure, 页码：1678-1688 , 文章类型： Article，,卷期：2008年16-11]
- Rotavirus RNA-dependent RNA polymerase VP1 catalyzes RNA synthesis within a subviral particle. This activity depends on core shell protein VP2. A conserved sequence at the 3' end of plus-strand RNA templates is important...
- Small-Molecule CD4 Mimics Interact with a Highly Conserved Pocket on HIV-1 gp120
[作者：Madani, N; Schon, A; Princiotto, AM; LaLonde, JM; Courter, JR; Soeta, T; Ng, D; Wang, LP; Brower, ET; Xiang, SH; Do Kwon, Y; Huang, CC; Wyatt, R; Kwong, PD; Freire, E; Smith, AB; Sodroski, J,期刊：Structure, 页码：1689-1701 , 文章类型： Article，,卷期：2008年16-11]
- Human immunodeficiency virus (HIV-1) interaction with the primary receptor, CD4, induces conformational changes in the viral envelope glycoproteins that allow binding to the CCR5 second receptor and virus entry into the ...
- Insights into the Nature of DNA Binding of AbrB-like Transcription Factors
[作者：Sullivan, DM; Bobay, BG; Kojetin, DJ; Thompson, RJ; Rance, M; Strauch, MA; Cavanagh, J,期刊：Structure, 页码：1702-1713 , 文章类型： Article，,卷期：2008年16-11]
- Understanding the DNA recognition and binding by the AbrB-like family of transcriptional regulators is of significant interest since these proteins enable bacteria to elicit the appropriate response to diverse environmen...
- Structural Basis for Catalytic and Inhibitory Mechanisms of Human Prostaglandin Reductase PTGR2
[作者：Wu, YH; Ko, TP; Guo, RT; Hu, SM; Chuang, LM; Wang, AHJ,期刊：Structure, 页码：1714-1723 , 文章类型： Article，,卷期：2008年16-11]
- PTGR2 catalyzes an NADPH-dependent reduction of the conjugated alpha,beta-unsaturated double bond of 15-keto-PGE(2), a key step in terminal inactivation of prostaglandins and suppression of PPAR gamma-mediated adipocyte ...
- Structural Determinants of Polymerization Reactivity of the P pilus Adaptor Subunit PapF
[作者：Verger, D; Rose, RJ; Paci, E; Costakes, G; Daviter, T; Hultgren, S; Remaut, H; Ashcroft, AE; Radford, SE; Waksman, G,期刊：Structure, 页码：1724-1731 , 文章类型： Article，,卷期：2008年16-11]
- P pili are important adhesive fibers involved in kidney infection by uropathogenic Escherichia coli. Pilus subunits are characterized by a large groove resulting from lack of a beta strand. Polymerization of pilus subuni...
- Structure of the Kinesin13-Microtubule Ring Complex
[作者：Tan, DY; Rice, WJ; Sosa, H,期刊：Structure, 页码：1732-1739 , 文章类型： Article，,卷期：2008年16-11]
- To investigate the mechanism of kinesin13-induced microtubule depolymerization, we have calculated a three-dimensional (3D) map of the kinesin13-microtubule ring complex, using cryo-electron microscopy (cryo-EM) and imag...
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