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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共17条记录   Detection of Functionally Important Regions in "Hypothetical Proteins" of Known Structure [作者：Nimrod, G; Schushan, M; Steinberg, DM; Ben-Tal, N,期刊：Structure, 页码：1755-1763 , 文章类型： Article，,卷期：2008年16-12] Structural genomics initiatives provide ample structures of "hypothetical proteins" (i.e., proteins of unknown function) at an ever increasing rate. However, without function annotation, this structural goldmine is of li... Determination of Protein Structures in the Solid State from NMR Chemical Shifts [作者：Robustelli, P; Cavalli, A; Vendruscolo, M,期刊：Structure, 页码：1764-1769 , 文章类型： Article，,卷期：2008年16-12] Solid-state NMR spectroscopy does not require proteins to form crystalline or soluble samples and can thus be applied under a variety of conditions, including precipitates, gels, and microcrystals. It has recently been s... Heterogeneity of Large Macromolecular Complexes Revealed by 3D Cryo-EM Variance Analysis [作者：Zhang, W; Kirnmel, M; Spahn, CMT; Penczek, PA,期刊：Structure, 页码：1770-1776 , 文章类型： Article，,卷期：2008年16-12] Macromolecular structure determination by cryo-electron microscopy (EM) and single-particle analysis are based on the assumption that imaged molecules have identical structure. With the increased size of processed data s... Prediction of Protein-Protein Interface Sequence Diversity Using Flexible Backbone Computational Protein Design [作者：Humphris, EL; Kortemme, T,期刊：Structure, 页码：1777-1788 , 文章类型： Article，,卷期：2008年16-12] A major challenge in computational protein design is to identify functional sequences as top predictions. One reason for design failures is conformational plasticity, as proteins frequently change their conformation in r... A Different Conformation for EGC Stator Subcomplex in Solution and in the Assembled Yeast V-ATPase: Possible Implications for Regulatory Disassembly [作者：Diepholz, M; Venzke, D; Prinz, S; Batisse, C; Florchinger, B; Rossle, M; Svergun, DI; Bottcher, B; Fethiere, J,期刊：Structure, 页码：1789-1798 , 文章类型： Article，,卷期：2008年16-12] Vacuolar ATPases (V-ATPases) are ATP-dependent proton pumps that maintain the acidity of cellular compartments. They are composed of a membrane-integrated proton-translocating V-0 and an extrinsic cytoplasmic catalytic d... Computer-Based Redesign of a beta Sandwich Protein Suggests that Extensive Negative Design Is Not Required for De Novo beta Sheet Design [作者：Hu, XZ; Wang, HC; Ke, HM; Kuhlman, B,期刊：Structure, 页码：1799-1805 , 文章类型： Article，,卷期：2008年16-12] The de novo design of globular beta sheet proteins remains largely an unsolved problem. It is unclear whether most designs are failing because the designed sequences do not have favorable energies in the target conformat... Pellino Proteins Contain a Cryptic FHA Domain that Mediates Interaction with Phosphorylated IRAK1 [作者：Lin, CC; Huoh, YS; Schmitz, KR; Jensen, LE; Ferguson, KM,期刊：Structure, 页码：1806-1816 , 文章类型： Article，,卷期：2008年16-12] Pellino proteins are RING E3 ubiquitin ligases involved in signaling events downstream of the Toll and interleukin-1 (IL-1) receptors, key initiators of innate immune and inflammatory responses. Pellino proteins associat... Structural Basis for Calcium Sensing by GCaMP2 [作者：Wang, Q; Shui, B; Kotlikoff, MI; Sondermann, H,期刊：Structure, 页码：1817-1827 , 文章类型： Article，,卷期：2008年16-12] Genetically encoded Ca2+ indicators are important tools that enable the measurement of Ca2+ dynamics in a physiologically relevant context. GCaMP2, one of the most robust indicators, is a circularly permutated EGFP (cpEG... Early Interrogation and Recognition of DNA Sequence by Indirect Readout [作者：Little, EJ; Babic, AC; Horton, NC,期刊：Structure, 页码：1828-1837 , 文章类型： Article，,卷期：2008年16-12] Control of replication, transcription, recombination and repair requires proteins capable of finding particular DNA sequences in a background of a large excess of nonspecific sequences. Such recognition can involve direc... Sortase-Mediated Pilus Fiber Biogenesis in Streptococcus pneumoniae [作者：Manzano, C; Contreras-Martel, C; El Mortaji, L; Izore, T; Fenel, D; Vernet, T; Schoehn, G; Di Guilmi, AM; Dessen, A,期刊：Structure, 页码：1838-1848 , 文章类型： Article，,卷期：2008年16-12] Streptococcus pneumoniae is a piliated pathogen whose ability to circumvent vaccination and antibiotic treatment strategies is a cause of mortality worldwide. Pili play important roles in pneumococcal infection, but litt... Structural Basis for Inactivation of the Human Pyruvate Dehydrogenase Complex by Phosphorylation: Role of Disordered Phosphorylation Loops [作者：Kato, M; Wynn, RM; Chuang, JL; Tso, SC; Machius, M; Li, J; Chuang, DT,期刊：Structure, 页码：1849-1859 , 文章类型： Article，,卷期：2008年16-12] We report the crystal structures of the phosporylated pyruvate dehydrogenase (El p) component of the human pyruvate dehydrogenase complex (PDC). The complete phosphorylation at Ser264-alpha (site 1) of a variant El p pro... Snapshots of Catalysis in the E1 Subunit of the Pyruvate Dehydrogenase Multienzyme Complex [作者：Pei, XY; Titman, CM; Frank, RAW; Leeper, FJ; Luisi, BF,期刊：Structure, 页码：1860-1872 , 文章类型： Article，,卷期：2008年16-12] The pyruvate dehydrogenase multienzyme assembly (PDH) generates acetyl coenzyme A and reducing equivalents from pyruvate in a multiple-step process that is a nexus of central metabolism. We report crystal structures of t... Crystal Structure of YaeT: Conformational Flexibility and Substrate Recognition [作者：Gatzeva-Topalova, PZ; Walton, TA; Sousa, MC,期刊：Structure, 页码：1873-1881 , 文章类型： Article，,卷期：2008年16-12] The envelope of Gram-negative bacteria consists of inner and outer membranes surrounding the peptidoglycan wall. The outer membrane (OM) is rich in integral membrane proteins (OMPs), which have a characteristic 0 barrel ... The 3D Structure of Villin as an Unusual F-Actin Crosslinker [作者：Hampton, CM; Liu, J; Taylor, DW; DeRosier, DJ; Taylor, KA,期刊：Structure, 页码：1882-1891 , 文章类型： Article，,卷期：2008年16-12] Villin is an F-actin nucleating, crosslinking, severing, and capping protein within the gelsolin superfamily. We have used electron tomography of 2D arrays of villin-crosslinked F-actin to generate 3D images revealing vi... Structural Basis for DNA Binding by Replication Initiator Mcm10 [作者：Warren, EM; Vaithiyalingam, S; Haworth, J; Greer, B; Bielinsky, AK; Chazin, WJ; Eichman, BF,期刊：Structure, 页码：1892-1901 , 文章类型： Article，,卷期：2008年16-12] Mcm10 is an essential eukaryotic DNA replication protein required for assembly and progression of the replication fork. The highly conserved internal domain (Mcm10-ID) has been shown to physically interact with single-st... Intricacies of beta Sheet Protein Design [作者：Shifman, JM,期刊：Structure, 页码：1751-1752 , 文章类型： Editorial Material，,卷期：2008年16-12]