- Phosphorylated Grb14 Is an Endogenous Inhibitor of Retinal Protein Tyrosine Phosphatase 1B, and Light-Dependent Activation of Src Phosphorylates Grb14
[作者:Basavarajappa, DK; Gupta, VK; Dighe, R; Rajala, A; Rajala, RVS,期刊:Molecular and Cellular Biology, 页码:3975-3987 , 文章类型: Article,,卷期:2011年31-19]
- Growth factor receptor-bound protein 14 (Grb14) is an adapter protein implicated in receptor tyrosine kinase signaling. Grb14(-/-) studies highlight both the positive and negative roles of Grb14 in receptor tyrosine kina...
- The LYR Protein Mzm1 Functions in the Insertion of the Rieske Fe/S Protein in Yeast Mitochondria
[作者:Atkinson, A; Smith, P; Fox, JL; Cui, TZ; Khalimonchuk, O; Winge, DR,期刊:Molecular and Cellular Biology, 页码:3988-3996 , 文章类型: Article,,卷期:2011年31-19]
- The assembly of the cytochrome bc(1) complex in Saccharomyces cerevisiae is shown to be conditionally dependent on a novel factor, Mzm1. Cells lacking Mzm1 exhibit a modest bc(1) defect at 30 degrees C, but the defect is...
- Pirh2 E3 Ubiquitin Ligase Monoubiquitinates DNA Polymerase Eta To Suppress Translesion DNA Synthesis
[作者:Jung, YS; Hakem, A; Hakem, R; Chen, XB,期刊:Molecular and Cellular Biology, 页码:3997-4006 , 文章类型: Article,,卷期:2011年31-19]
- Polymerase eta (PolH) is necessary for translesion DNA synthesis, and PolH deficiency predisposes xeroderma pigmentosum variant (XPV) patients to cancer. Due to the critical role of PolH in translesion DNA synthesis, the...
- Ribosomal Protein L11 Recruits miR-24/miRISC To Repress c-Myc Expression in Response to Ribosomal Stress
[作者:Challagundla, KB; Sun, XX; Zhang, XL; DeVine, T; Zhang, QH; Sears, RC; Dai, MS,期刊:Molecular and Cellular Biology, 页码:4007-4021 , 文章类型: Article,,卷期:2011年31-19]
- c-Myc promotes cell growth by enhancing ribosomal biogenesis and translation. Deregulated expression of c-Myc and aberrant ribosomal biogenesis and translation contribute to tumorigenesis. Thus, a fine coordination betwe...
- Analysis of Human Syndromes with Disordered Chromatin Reveals the Impact of Heterochromatin on the Efficacy of ATM-Dependent G(2)/M Checkpoint Arrest
[作者:Brunton, H; Goodarzi, AA; Noon, AT; Shrikhande, A; Hansen, RS; Jeggo, PA; Shibata, A,期刊:Molecular and Cellular Biology, 页码:4022-4035 , 文章类型: Article,,卷期:2011年31-19]
- Heterochromatin (HC) poses a barrier to gamma H2AX focus expansion and DNA double-strand break (DSB) repair, the latter being relieved by ATM-dependent KAP-1 phosphorylation. Using high-resolution imaging, we show here t...
- A Pathway for the Control of Anoikis Sensitivity by E-Cadherin and Epithelial-to-Mesenchymal Transition
[作者:Kumar, S; Park, SH; Cieply, B; Schupp, J; Killiam, E; Zhang, F; Rimm, DL; Frisch, SM,期刊:Molecular and Cellular Biology, 页码:4036-4051 , 文章类型: Article,,卷期:2011年31-19]
- Detachment of epithelial cells from matrix or attachment to an inappropriate matrix engages an apoptotic response known as anoikis, which prevents metastasis. Cellular sensitivity to anoikis is compromised during the onc...
- Balanced Interactions between Lyn, the p85 alpha Regulatory Subunit of Class I(A) Phosphatidylinositol-3-Kinase, and SHIP Are Essential for Mast Cell Growth and Maturation
[作者:Ma, PL; Vemula, S; Munugalavadla, V; Chen, JB; Sims, E; Borneo, J; Kondo, T; Ramdas, B; Mali, RS; Li, S; Hashino, E; Takemoto, C; Kapur, R,期刊:Molecular and Cellular Biology, 页码:4052-4062 , 文章类型: Article,,卷期:2011年31-19]
- The growth and maturation of bone marrow-derived mast cells (BMMCs) from precursors are regulated by coordinated signals from multiple cytokine receptors, including KIT. While studies conducted using mutant forms of thes...
- Antagonistic Regulation of Cystic Fibrosis Transmembrane Conductance Regulator Cell Surface Expression by Protein Kinases WNK4 and Spleen Tyrosine Kinase
[作者:Mendes, AI; Matos, P; Moniz, S; Luz, S; Amaral, MD; Farinha, CM; Jordan, P,期刊:Molecular and Cellular Biology, 页码:4076-4086 , 文章类型: Article,,卷期:2011年31-19]
- Members of the WNK (with-no-lysine [K]) subfamily of protein kinases regulate various ion channels involved in sodium, potassium, and chloride homeostasis by either inducing their phosphorylation or regulating the number...
- MicroRNA-155 Promotes Resolution of Hypoxia-Inducible Factor 1 alpha Activity during Prolonged Hypoxia
[作者:Bruning, U; Cerone, L; Neufeld, Z; Fitzpatrick, SF; Cheong, A; Scholz, CC; Simpson, DA; Leonard, MO; Tambuwala, MM; Cummins, EP; Taylor, CT,期刊:Molecular and Cellular Biology, 页码:4087-4096 , 文章类型: Article,,卷期:2011年31-19]
- The hypoxia-inducible factor (HIF) is a key regulator of the transcriptional response to hypoxia. While the mechanism underpinning HIF activation is well understood, little is known about its resolution. Both the protein...
- Vital Role of the Calpain-Calpastatin System for Placental-Integrity-Dependent Embryonic Survival
[作者:Takano, J; Mihira, N; Fujioka, R; Hosoki, E; Chishti, AH; Saido, TC,期刊:Molecular and Cellular Biology, 页码:4097-4106 , 文章类型: Article,,卷期:2011年31-19]
- Although the calpain-calpastatin system has been implicated in a number of pathological conditions, its normal physiological role remains largely unknown. To investigate the functions of this system, we generated convent...
- Human CABIN1 Is a Functional Member of the Human HIRA/UBN1/ASF1a Histone H3.3 Chaperone Complex
[作者:Rai, TS; Puri, A; McBryan, T; Hoffman, J; Tang, Y; Pchelintsev, NA; van Tuyn, J; Marmorstein, R; Schultz, DC; Adams, PD,期刊:Molecular and Cellular Biology, 页码:4107-4118 , 文章类型: Article,,卷期:2011年31-19]
- The mammalian HIRA/UBN1/ASF1a complex is a histone chaperone complex that is conserved from yeast (Saccharomyces cerevisiae) to humans. This complex preferentially deposits the histone variant H3.3 into chromatin in a DN...
- Genomic DNA Hypomethylation by Histone Deacetylase Inhibition Implicates DNMT1 Nuclear Dynamics
[作者:Arzenani, MK; Zade, AE; Ming, Y; Vijverberg, SJH; Zhang, Z; Khan, Z; Sadique, S; Kallenbach, L; Hu, LF; Vukojevic, V; Ekstrom, TJ,期刊:Molecular and Cellular Biology, 页码:4119-4128 , 文章类型: Article,,卷期:2011年31-19]
- Histone deacetylase inhibitors (HDACi) are promising antitumor drugs acting through reactivation of silenced tumor suppressor genes. Several HDACi are currently in clinical trials both for hematological and solid tissue ...
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