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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共25条记录   A Cytosolic ATM/NEMO/RIP1 Complex Recruits TAK1 To Mediate the NF-kappa B and p38 Mitogen-Activated Protein Kinase (MAPK)/MAPK-Activated Protein 2 Responses to DNA Damage [作者：Yang, YB; Xia, F; Hermance, N; Mabb, A; Simonson, S; Morrissey, S; Gandhi, P; Munson, M; Miyamoto, S; Kelliher, MA,期刊：Molecular and Cellular Biology, 页码：2774-2786 , 文章类型： Article，,卷期：2011年31-14] In multiple tumor types, activation of the transcription factor NF-kappa B increases the resistance of tumor cells to anticancer therapies and contributes to tumor progression. Genotoxic stress induced by chemotherapy or... mTOR Kinase Domain Phosphorylation Promotes mTORC1 Signaling, Cell Growth, and Cell Cycle Progression [作者：Ekim, B; Magnuson, B; Acosta-Jaquez, HA; Keller, JA; Feener, EP; Fingar, DC,期刊：Molecular and Cellular Biology, 页码：2787-2801 , 文章类型： Article，,卷期：2011年31-14] The mammalian target of rapamycin complex 1 (mTORC1) functions as an environmental sensor to promote critical cellular processes such as protein synthesis, cell growth, and cell proliferation in response to growth factor... Exogenous Signal-Independent Nuclear I kappa B Kinase Activation Triggered by Nkx3.2 Enables Constitutive Nuclear Degradation of I kappa B-alpha in Chondrocytes [作者：Yong, Y; Choi, SW; Choi, HJ; Nam, HW; Kim, JA; Jeong, DU; Kim, DY; Kim, YS; Kim, DW,期刊：Molecular and Cellular Biology, 页码：2802-2816 , 文章类型： Article，,卷期：2011年31-14] NF-kappa B is a multifunctional transcription factor involved in diverse biological processes. It has been well documented that NF-kappa B can be activated in response to various stimuli. While signal-inducible NF-kappa ... A Runx1-Smad6 Rheostat Controls Runx1 Activity during Embryonic Hematopoiesis [作者：Knezevic, K; Bee, T; Wilson, NK; Janes, ME; Kinston, S; Polderdijk, S; Kolb-Kokocinski, A; Ottersbach, K; Pencovich, N; Groner, Y; de Bruijn, M; Gottgens, B; Pimanda, JE,期刊：Molecular and Cellular Biology, 页码：2817-2826 , 文章类型： Article，,卷期：2011年31-14] The oncogenic transcription factor Runx1 is required for the specification of definitive hematopoietic stem cells (HSC) in the developing embryo. The activity of this master regulator is tightly controlled during develop... An Extended Domain of Kcnq1ot1 Silencing Revealed by an Imprinted Fluorescent Reporter [作者：Jones, MJ; Bogutz, AB; Lefebvre, L,期刊：Molecular and Cellular Biology, 页码：2827-2837 , 文章类型： Article，,卷期：2011年31-14] The distal region of mouse chromosome 7 contains two imprinted domains separated by a relatively gene-poor interval. We have previously described a transgenic mouse line called Tel7KI, which contains a green fluorescent ... Impaired Locomotor Learning and Altered Cerebellar Synaptic Plasticity in pep-19/pcp4-Null Mice [作者：Wei, P; Blundon, JA; Rong, YQ; Zakharenko, SS; Morgan, JI,期刊：Molecular and Cellular Biology, 页码：2838-2844 , 文章类型： Article，,卷期：2011年31-14] PEP-19/PCP4 maps within the Down syndrome critical region and encodes a small, predominantly neuronal, IQ motif protein. Pep-19 binds calmodulin and inhibits calmodulin-dependent signaling, which is critical for synaptic... Molecular Mechanisms of Calmodulin Action on TRPV5 and Modulation by Parathyroid Hormone [作者：de Groot, T; Kovalevskaya, NV; Verkaart, S; Schilderink, N; Felici, M; van der Hagen, EAE; Bindels, RJM; Vuister, GW; Hoenderop, JG,期刊：Molecular and Cellular Biology, 页码：2845-2853 , 文章类型： Article，,卷期：2011年31-14] The epithelial Ca2+ channel transient receptor potential vanilloid 5 (TRPV5) constitutes the apical entry gate for active Ca2+ reabsorption in the kidney. Ca2+ influx through TRPV5 induces rapid channel inactivation, pre... Gamma Interferon Modulates Myogenesis through the Major Histocompatibility Complex Class II Transactivator, CIITA [作者：Londhe, P; Davie, JK,期刊：Molecular and Cellular Biology, 页码：2854-2866 , 文章类型： Article，,卷期：2011年31-14] Gamma interferon (IFN-gamma) is an inflammatory cytokine that has complex effects on myogenesis. Here, we show that the IFN-gamma-induced inhibition of myogenesis is mediated by the major histocompatibility complex (MHC)... Relieving Autophagy and 4EBP1 from Rapamycin Resistance [作者：Nyfeler, B; Bergman, P; Triantafellow, E; Wilson, CJ; Zhu, YY; Radetich, B; Finan, PM; Klionsky, DJ; Murphy, LO,期刊：Molecular and Cellular Biology, 页码：2867-2876 , 文章类型： Article，,卷期：2011年31-14] The mammalian target of rapamycin complex 1 (mTORC1) is a multiprotein signaling complex regulated by oncogenes and tumor suppressors. Outputs downstream of mTORC1 include ribosomal protein S6 kinase 1 (S6K1), eukaryotic... Coordinated Action of CK1 Isoforms in Canonical Wnt Signaling [作者：del Valle-Perez, B; Arques, O; Vinyoles, M; de Herreros, AG; Dunach, M,期刊：Molecular and Cellular Biology, 页码：2877-2888 , 文章类型： Article，,卷期：2011年31-14] Activation of the Wnt pathway promotes the progressive phosphorylation of coreceptor LRP5/6 (low-density lipoprotein receptor-related proteins 5 and 6), creating a phosphorylated motif that inhibits glycogen synthase kin... Interferon Regulatory Factor 2 Binding Protein 2 Is a New NFAT1 Partner and Represses Its Transcriptional Activity [作者：Carneiro, FRG; Ramalho-Oliveira, R; Mognol, GP; Viola, JPB,期刊：Molecular and Cellular Biology, 页码：2889-2901 , 文章类型： Article，,卷期：2011年31-14] The nuclear factor of activated T cells (NFAT) family of transcription factors is expressed in a wide range of cell types and regulates genes involved in cell cycle, differentiation, and apoptosis. NFAT proteins share tw... Squamous Cell Carcinoma Antigen 1 Promotes Caspase-8-Mediated Apoptosis in Response to Endoplasmic Reticulum Stress While Inhibiting Necrosis Induced by Lysosomal Injury [作者：Ullman, E; Pan, JA; Zong, WX,期刊：Molecular and Cellular Biology, 页码：2902-2919 , 文章类型： Article，,卷期：2011年31-14] Squamous cell carcinoma antigen 1 (SCCA1) is a member of the serine protease inhibitor (serpin) family of proteins, whose target proteases include the cathepsins. Initially identified as a serological marker for advanced... Mammalian Llgl2 Is Necessary for Proper Branching Morphogenesis during Placental Development [作者：Sripathy, S; Lee, M; Vasioukhin, V,期刊：Molecular and Cellular Biology, 页码：2920-2933 , 文章类型： Article，,卷期：2011年31-14] Cell polarity plays a critical role in the development of all metazoans; however, the mechanisms of cell polarity and the specific role of cell polarity pathways in mammalian organisms are still poorly understood. Lethal... NF-kappa B Protects Cells from Gamma Interferon-Induced RIP1-Dependent Necroptosis [作者：Thapa, RJ; Basagoudanavar, SH; Nogusa, S; Irrinki, K; Mallilankaraman, K; Slifker, MJ; Beg, AA; Madesh, M; Balachandran, S,期刊：Molecular and Cellular Biology, 页码：2934-2946 , 文章类型： Article，,卷期：2011年31-14] Interferons (IFNs) are cytokines with well-described immunomodulatory and antiviral properties, but less is known about the mechanisms by which they promote cell survival or cell death. Here, we show that IFN-gamma induc... Phosphorylation of Eukaryotic Translation Initiation Factor 4G1 (eIF4G1) by Protein Kinase C alpha Regulates eIF4G1 Binding to Mnk1 [作者：Dobrikov, M; Dobrikova, E; Shveygert, M; Gromeier, M,期刊：Molecular and Cellular Biology, 页码：2947-2959 , 文章类型： Article，,卷期：2011年31-14] Signal transduction through mitogen-activated protein kinases (MAPKs) is implicated in growth and proliferation control through translation regulation and involves posttranslational modification of translation initiation... Spn1 Regulates the GNBP3-Dependent Toll Signaling Pathway in Drosophila melanogaster [作者：Fullaondo, A; Garcia-Sanchez, S; Sanz-Parra, A; Recio, E; Lee, SY; Gubb, D,期刊：Molecular and Cellular Biology, 页码：2960-2972 , 文章类型： Article，,卷期：2011年31-14] The Drosophila genome encodes 29 serpins, most of unknown function. We show here that Spn1 is an active protease inhibitor of the serpin superfamily. Spn1 inhibits trypsin in vitro and regulates the Toll-mediated immune ...