- Increased Expression and Activity of 12-Lipoxygenase in Oxygen-Induced Ischemic Retinopathy and Proliferative Diabetic Retinopathy Implications in Retinal Neovascularization
[作者:Al-Shabrawey, M; Mussell, R; Kahook, K; Tawfik, A; Eladl, M; Sarthy, V; Nussbaum, J; El-Marakby, A; Park, SY; Gurel, Z; Sheibani, N; Maddipati, KR,期刊:Diabetes, 页码:614-624 , 文章类型: Article,,卷期:2011年60-2]
- OBJECTIVE-Arachidonic acid is metabolized by 12-lipoxygenase (12-LOX) to 12-hydroxyeicosatetraenoic acid (12-HETE) and has an important role in the regulation of angiogenesis and endothelial cell proliferation and migrat...
- Diabetic Downregulation of Nrf2 Activity via ERK Contributes to Oxidative Stress-Induced Insulin Resistance in Cardiac Cells In Vitro and In Vivo
[作者:Tan, Y; Ichikawa, T; Li, JQ; Si, QS; Yang, HT; Chen, XB; Goldblatt, CS; Meyer, CJ; Li, XK; Cai, L; Cui, TX,期刊:Diabetes, 页码:625-633 , 文章类型: Article,,卷期:2011年60-2]
- OBJECTIVE-Oxidative stress is implicated in cardiac insulin resistance, a critical risk factor for cardiac failure, but the direct evidence remains missing. This study explored a causal link between oxidative stress and ...
- Selective Reversible Inhibition of Liver Carnitine Palmitoyl-Transferase 1 by Teglicar Reduces Gluconeogenesis and Improves Glucose Homeostasis
[作者:Conti, R; Mannucci, E; Pessotto, P; Tassoni, E; Carminati, P; Giannessi, F; Arduini, A,期刊:Diabetes, 页码:644-651 , 文章类型: Article,,卷期:2011年60-2]
- OBJECTIVE-We have developed a new antihyperglycemic agent (teglicar) through the selective and reversible inhibition of the liver isoform of carnitine palinitoyl-transferase 1 (L-CPT1). RESEARCH DESIGN AND METHODS-Glucos...
- Effects of Acute Hyperglucagonemia on Hepatic and Intestinal Lipoprotein Production and Clearance in Healthy Humans
[作者:Xiao, CT; Pavlic, M; Szeto, L; Patterson, BW; Lewis, GF,期刊:Diabetes, 页码:383-390 , 文章类型: Article,,卷期:2011年60-2]
- OBJECTIVE-The metabolism of hepatic-and intestinally derived lipoproteins is regulated in a complex fashion by nutrients, hormones, and neurologic and other factors. Recent studies in animal models suggest an important r...
- Adiponectin Pretreatment Counteracts the Detrimental Effect of a Diabetic Environment on Endothelial Progenitors
[作者:Leicht, SF; Schwarz, TM; Hermann, PC; Seissler, J; Aicher, A; Heeschen, C,期刊:Diabetes, 页码:652-661 , 文章类型: Article,,卷期:2011年60-2]
- OBJECTIVE-It has been shown that vascular progenitors from patients with diabetes are dysfunctional. However, therapeutic strategies to counteract their reduced functional capacity are still lacking. Because adiponectin ...
- Resequencing and Analysis of Variation in the TCF7L2 Gene in African Americans Suggests That SNP rs7903146 Is the Causal Diabetes Susceptibility Variant
[作者:Palmer, ND; Hester, JM; An, SS; Adeyemo, A; Rotimi, C; Langefeld, CD; Freedman, BI; Ng, MCY; Bowden, DW,期刊:Diabetes, 页码:662-668 , 文章类型: Article,,卷期:2011年60-2]
- OBJECTIVE-Variation in the transcription factor 7-like 2 (TCF7L2) locus is associated with type 2 diabetes across multiple ethnicities. The aim of this study was to elucidate which variant in TCF7L2 confers diabetes susc...
- Hepatic Glycogen Supercompensation Activates AMP-Activated Protein Kinase, Impairs Insulin Signaling, and Reduces Glycogen Deposition in the Liver
[作者:Winnick, JJ; An, ZB; Ramnanan, CJ; Smith, M; Irimia, JM; Nea, DW; Moore, MC; Roach, PJ; Cherrington, AD,期刊:Diabetes, 页码:398-407 , 文章类型: Article,,卷期:2011年60-2]
- OBJECTIVE-The objective of this study was to determine how increasing the hepatic glycogen content would affect the liver's ability to take up and metabolize glucose. RESEARCH DESIGN AND METHODS-During the first 4 h of t...
- Normal Postprandial Nonesterified Fatty Acid Uptake in Muscles Despite Increased Circulating Fatty Acids in Type 2 Diabetes
[作者:Labbe, SM; Croteau, E; Grenier-Larouche, T; Frisch, F; Ouellet, R; Langlois, R; Guerin, B; Turcotte, EE; Carpentier, AC,期刊:Diabetes, 页码:408-415 , 文章类型: Article,,卷期:2011年60-2]
- OBJECTIVE-Postprandial plasma nonesterified fatty acid (NEFA) appearance is increased in type 2 diabetes. Our objective was to determine whether skeletal muscle uptake of plasma NEFA is abnormal during the postprandial s...
- Links Between Insulin Resistance, Adenosine A(2B) Receptors, and Inflammatory Markers in Mice and Humans
[作者:Figler, RA; Wang, GQ; Srinivasan, S; Jung, DY; Zhang, ZY; Pankow, JS; Ravid, K; Fredholm, B; Hedrick, CC; Rich, SS; Kim, JK; LaNoue, KF; Linden, J,期刊:Diabetes, 页码:669-679 , 文章类型: Article,,卷期:2011年60-2]
- OBJECTIVE-To determine the mechanisms by which blockade of adenosine A(2B) receptors (A(2B)Rs) reduces insulin resistance. RESEARCH DESIGN AND METHODS-We investigated the effects of deleting or blocking the A(2B)R on ins...
- The Same Chromosome 9p21.3 Locus Is Associated With Type 2 Diabetes and Coronary Artery Disease in a Chinese Han Population
[作者:Cheng, XA; Shi, LS; Nie, SF; Wang, F; Li, XC; Xu, CQ; Wang, PY; Yang, BF; Li, QX; Pan, ZW; Li, Y; Xia, H; Zheng, CH; Ke, YH; Wu, YX; Tang, TT; Yan, XX; Yang, Y; Xia, N; Yao, R; Wang, BB; Ma, X; Zeng, QT; Tu, X; Liao, YH; Wang, QK,期刊:Diabetes, 页码:680-684 , 文章类型: Article,,卷期:2011年60-2]
- OBJECTIVE-Recent genome-wide association studies (GWAS) revealed that a 9p21.3 locus was associated with type 2 diabetes. In this study, we carried out a large-scale case-control study in the GeneID Chinese Han populatio...
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