- Central Endocannabinoid Signaling Regulates Hepatic Glucose Production and Systemic Lipolysis
[作者:O'Hare, JD; Zielinski, E; Cheng, B; Scherer, T; Buettner, C,期刊:Diabetes, 页码:1055-1062 , 文章类型: Article,,卷期:2011年60-4]
- OBJECTIVE-The endocannabinoid (EC) system has been implicated as an important regulator of energy homeostasis. In obesity and type 2 diabetes, EC tone is elevated in peripheral tissues including liver, muscle, fat, and a...
- Neuronal Receptor Activity-Modifying Protein 1 Promotes Energy Expenditure in Mice
[作者:Zhang, ZM; Liu, XB; Morgan, DA; Kuburas, A; Thedens, DR; Russo, AF; Rahmouni, K,期刊:Diabetes, 页码:1063-1071 , 文章类型: Article,,卷期:2011年60-4]
- OBJECTIVE-Receptor activity-modifying proteins (RAMPs) 1, 2, and 3 are unusual accessory proteins that dictate the binding specificity of two G protein-coupled receptors involved in energy homeostasis: calcitonin gene-re...
- Endoplasmic Reticulum Stress Promotes LIPIN2-Dependent Hepatic Insulin Resistance
[作者:Ryu, D; Seo, WY; Yoon, YS; Kim, YN; Kim, SS; Kim, HJ; Park, TS; Choi, CS; Koo, SH,期刊:Diabetes, 页码:1072-1081 , 文章类型: Article,,卷期:2011年60-4]
- OBJECTIVE-Diet-induced obesity (DIO) is linked to peripheral insulin resistance-a major predicament in type 2 diabetes. This study aims to identify the molecular mechanism by which DIO-triggered endoplasmic reticulum (ER...
- Disruption of Thyroid Hormone Activation in Type 2 Deiodinase Knockout Mice Causes Obesity With Glucose Intolerance and Liver Steatosis Only at Thermoneutrality
[作者:Castillo, M; Hall, JA; Correa-Medina, M; Ueta, C; Kang, HW; Cohen, DE; Bianco, AC,期刊:Diabetes, 页码:1082-1089 , 文章类型: Article,,卷期:2011年60-4]
- OBJECTIVE-Thyroid hormone accelerates energy expenditure; thus, hypothyroidism is intuitively associated with obesity. However, studies failed to establish such a connection. In brown adipose tissue (BAT), thyroid hormon...
- High Pancreatic n-3 Fatty Acids Prevent STZ-Induced Diabetes in Fat-1 Mice: Inflammatory Pathway Inhibition
[作者:Bellenger, J; Bellenger, S; Bataille, A; Massey, KA; Nicolaou, A; Rialland, M; Tessier, C; Kang, JX; Narce, M,期刊:Diabetes, 页码:1090-1099 , 文章类型: Article,,卷期:2011年60-4]
- OBJECTIVE-Because of confounding factors, the effects of dietary n-3 polyunsaturated fatty acids (PUFA) on type 1 diabetes remain to be clarified. We therefore evaluated whether fat-1 transgenic mice, a well-controlled e...
- Hematopoietic Cell-Restricted Deletion of CD36 Reduces High-Fat Diet-Induced Macrophage Infiltration and Improves Insulin Signaling in Adipose Tissue
[作者:Nicholls, HT; Kowalski, G; Kennedy, DJ; Risis, S; Zaffino, LA; Watson, N; Kanellakis, P; Watt, MJ; Bobik, A; Bonen, A; Febbraio, M; Lancaster, GI; Febbraio, MA,期刊:Diabetes, 页码:1100-1110 , 文章类型: Article,,卷期:2011年60-4]
- OBJECTIVE-The fatty acid translocase and scavenger receptor CD36 is important in the recognition and uptake of lipids. Accordingly, we hypothesized that it plays a role in saturated fatty acid-induced macrophage lipid ac...
- Bimodal Effect on Pancreatic beta-Cells of Secretory Products From Normal or Insulin-Resistant Human Skeletal Muscle
[作者:Bouzakri, K; Plomgaard, P; Berney, T; Donath, MY; Pedersen, BK; Halban, PA,期刊:Diabetes, 页码:1111-1121 , 文章类型: Article,,卷期:2011年60-4]
- OBJECTIVE-Type 2 diabetes is characterized by insulin resistance with a relative deficiency in insulin secretion. This study explored the potential communication between insulin-resistant human skeletal muscle and primar...
- Prevention of "Humanized" Diabetogenic CD8 T-Cell Responses in HLA-Transgenic NOD Mice by a Multipeptide Coupled-Cell Approach
[作者:Niens, M; Grier, AE; Marron, M; Kay, TWH; Greiner, DL; Serreze, DV,期刊:Diabetes, 页码:1229-1236 , 文章类型: Article,,卷期:2011年60-4]
- OBJECTIVE-Type 1 diabetes can be inhibited in standard NOD mice by autoantigen-specific immunotherapy targeting pathogenic CD8+ T-cells. NOD.beta 2m(null).HHD mice expressing human HLA-A2.1 but lacking murine major histo...
- Retinal Microglial Activation and Inflammation Induced by Amadori-Glycated Albumin in a Rat Model of Diabetes
[作者:Ibrahim, AS; El-Remessy, AB; Matragoon, S; Zhang, WB; Patel, Y; Khan, S; Al-Gayyar, MM; El-Shishtawy, MM; Liou, GI,期刊:Diabetes, 页码:1122-1133 , 文章类型: Article,,卷期:2011年60-4]
- OBJECTIVE-During diabetes, retinal microglial cells are activated to release inflammatory cytokines that, initiate neuronal loss and blood-retinal barrier breakdown seen in diabetic retinopathy (DR). The mechanism by whi...
- p38 Mitogen-Activated Protein Kinase-Dependent Transactivation of ErbB Receptor Family A Novel Common Mechanism for Stress-Induced IRS-1 Serine Phosphorylation and Insulin Resistance
[作者:Hemi, R; Yochananov, Y; Barhod, E; Kasher-Meron, M; Karasik, A; Tirosh, A; Kanety, H,期刊:Diabetes, 页码:1134-1145 , 文章类型: Article,,卷期:2011年60-4]
- OBJECTIVE-Stress stimuli such as tumor necrosis factor (TNF) have been shown to induce insulin receptor substrate (IRS)-1 serine phosphorylation and insulin resistance by transactivation of ErbB receptors. We aimed at el...
- Evidence That Nasal Insulin Induces Immune Tolerance to Insulin in Adults With Autoimmune Diabetes
[作者:Fourlanos, S; Perry, C; Gellert, SA; Martinuzzi, E; Mallone, R; Butler, J; Cohnan, PG; Harrison, LC,期刊:Diabetes, 页码:1237-1245 , 文章类型: Article,,卷期:2011年60-4]
- OBJECTIVE-Insulin in pancreatic beta-cells is a target of autoimmunity in type 1 diabetes. In the NOD mouse model of type 1 diabetes, oral or nasal administration of insulin induces immune tolerance to insulin and protec...
- Novel Fat Depot-Specific Mechanisms Underlie Resistance to Visceral Obesity and Inflammation in 11 beta-Hydroxysteroid Dehydrogenase Type 1-Deficient Mice
[作者:Wamil, M; Battle, JH; Turban, S; Kipari, T; Seguret, D; Peixoto, RD; Nelson, YB; Nowakowska, D; Ferenbach, D; Ramage, L; Chapman, KE; Hughes, J; Dunbar, DR; Seckl, JR; Morton, NM,期刊:Diabetes, 页码:1158-1167 , 文章类型: Article,,卷期:2011年60-4]
- OBJECTIVE-The study objective was to determine the key early mechanisms underlying the beneficial redistribution, function, and inflammatory profile of adipose tissue in 11 beta-hydroxysteroid dehydrogenase type 1 knocko...
- Diet-Induced Adipose Tissue Inflammation and Liver Steatosis Are Prevented by DPP-4 Inhibition in Diabetic Mice
[作者:Shirakawa, J; Fujii, H; Ohnuma, K; Sato, K; Ito, Y; Kaji, M; Sakamoto, E; Koganei, M; Sasaki, H; Nagashima, Y; Amo, K; Aoki, K; Morimoto, C; Takeda, E; Terauchi, Y,期刊:Diabetes, 页码:1246-1257 , 文章类型: Article,,卷期:2011年60-4]
- OBJECTIVE-Diet composition alters the metabolic states of adipocytes and hepatocytes in diabetes. The effects of dipeptidyl peptidase-4 (DPP-4) inhibition on adipose tissue inflammation and fatty liver have been obscure....
- Hyperuricemia as a Mediator of the Proinflammatory Endocrine Imbalance in the Adipose Tissue in a Murine Model of the Metabolic Syndrome
[作者:Baldwin, W; McRae, S; Marek, G; Wymer, D; Pannu, V; Baylis, C; Johnson, RJ; Sautin, YY,期刊:Diabetes, 页码:1258-1269 , 文章类型: Article,,卷期:2011年60-4]
- OBJECTIVE-Hyperuricemia is strongly associated with obesity and metabolic syndrome and can predict visceral obesity and insulin resistance. Previously, we showed that soluble uric acid directly stimulated the redox-depen...
- Tumor Progression Locus 2 (TPL2) Regulates Obesity-Associated Inflammation and Insulin Resistance
[作者:Perfield, JW; Lee, Y; Shulman, GI; Samuel, VT; Jurczak, MJ; Chang, E; Xie, C; Tsichlis, PN; Obin, MS; Greenberg, AS,期刊:Diabetes, 页码:1168-1176 , 文章类型: Article,,卷期:2011年60-4]
- OBJECTIVE-Obesity-associated low-grade systemic inflammation resulting from increased adipose mass is strongly related to the development of insulin resistance and type 2 diabetes as well as other metabolic complications...
|