- A Quantitative High-Throughput In Vitro Splicing Assay Identifies Inhibitors of Spliceosome Catalysis
[作者:Berg, MG; Wan, LL; Younis, I; Diem, MD; Soo, M; Wang, CL; Dreyfuss, G,期刊:Molecular and Cellular Biology, 页码:1271-1283 , 文章类型: Article,,卷期:2012年32-7]
- Despite intensive research, there are very few reagents with which to modulate and dissect the mRNA splicing pathway. Here, we describe a novel approach to identify such tools, based on detection of the exon junction com...
- A Novel Role for Copper in Ras/Mitogen-Activated Protein Kinase Signaling
[作者:Turski, ML; Brady, DC; Kim, HJ; Kim, BE; Nose, Y; Counter, CM; Winge, DR; Thiele, DJ,期刊:Molecular and Cellular Biology, 页码:1284-1295 , 文章类型: Article,,卷期:2012年32-7]
- Copper (Cu) is essential for development and proliferation, yet the cellular requirements for Cu in these processes are not well defined. We report that Cu plays an unanticipated role in the mitogen-activated protein (MA...
- Retina Restored and Brain Abnormalities Ameliorated by Single-Copy Knock-In of Human NR2E1 in Null Mice
[作者:Schmouth, JF; Banks, KG; Mathelier, A; Gregory-Evans, CY; Castellarin, M; Holt, RA; Gregory-Evans, K; Wasserman, WW; Simpson, EM,期刊:Molecular and Cellular Biology, 页码:1296-1311 , 文章类型: Article,,卷期:2012年32-7]
- Nr2e1 encodes a stem cell fate determinant of the mouse forebrain and retina. Abnormal regulation of this gene results in retinal, brain, and behavioral abnormalities in mice. However, little is known about the functiona...
- The Spt5 C-Terminal Region Recruits Yeast 3 ' RNA Cleavage Factor I
[作者:Mayer, A; Schreieck, A; Lidschreiber, M; Leike, K; Martin, DE; Cramer, P,期刊:Molecular and Cellular Biology, 页码:1321-1331 , 文章类型: Article,,卷期:2012年32-7]
- During transcription elongation, RNA polymerase II (Pol II) binds the general elongation factor Spt5. Spt5 contains a repetitive C-terminal region (CTR) that is required for cotranscriptional recruitment of the Paf1 comp...
- HOXA9 Methylation by PRMT5 Is Essential for Endothelial Cell Expression of Leukocyte Adhesion Molecules
[作者:Bandyopadhyay, S; Harris, DP; Adams, GN; Lause, GE; McHugh, A; Tillmaand, EG; Money, A; Willard, B; Fox, PL; DiCorleto, PE,期刊:Molecular and Cellular Biology, 页码:1202-1213 , 文章类型: Article,,卷期:2012年32-7]
- The induction of proinflammatory proteins in stimulated endothelial cells (EC) requires activation of multiple transcription programs. The homeobox transcription factor HOXA9 has an important regulatory role in cytokine ...
- MdmX Is Required for p53 Interaction with and Full Induction of the Mdm2 Promoter after Cellular Stress
[作者:Biderman, L; Poyurovsky, MV; Assia, Y; Manley, JL; Prives, C,期刊:Molecular and Cellular Biology, 页码:1214-1225 , 文章类型: Article,,卷期:2012年32-7]
- The activity of the tumor suppressor p53 is tightly controlled by its main negative regulator, Mdm2, which inhibits p53's transcriptional activity and targets it for degradation via the proteasome pathway. The closely re...
- Hepatic Deletion of SIRT1 Decreases Hepatocyte Nuclear Factor 1 alpha/Farnesoid X Receptor Signaling and Induces Formation of Cholesterol Gallstones in Mice
[作者:Purushotham, A; Xu, Q; Lu, J; Foley, JF; Yan, XJ; Kim, DH; Kemper, JK; Li, XL,期刊:Molecular and Cellular Biology, 页码:1226-1236 , 文章类型: Article,,卷期:2012年32-7]
- SIRT1, a highly conserved NAD(+)-dependent protein deacetylase, is a key metabolic sensor that directly links nutrient signals to animal metabolic homeostasis. Although SIRT1 has been implicated in a number of hepatic me...
- Phosphorylation of BRN2 Modulates Its Interaction with the Pax3 Promoter To Control Melanocyte Migration and Proliferation
[作者:Berlin, I; Denat, L; Steunou, AL; Puig, I; Champeval, D; Colombo, S; Roberts, K; Bonvin, E; Bourgeois, Y; Davidson, I; Delmas, V; Nieto, L; Goding, CR; Larue, L,期刊:Molecular and Cellular Biology, 页码:1237-1247 , 文章类型: Article,,卷期:2012年32-7]
- MITF-M and PAX3 are proteins central to the establishment and transformation of the melanocyte lineage. They control various cellular mechanisms, including migration and proliferation. BRN2 is a POU domain transcription ...
- The E3 Ubiquitin Ligase TRAF6 Intercedes in Starvation-Induced Skeletal Muscle Atrophy through Multiple Mechanisms
[作者:Paul, PK; Bhatnagar, S; Mishra, V; Srivastava, S; Darnay, BG; Choi, Y; Kumar, A,期刊:Molecular and Cellular Biology, 页码:1248-1259 , 文章类型: Article,,卷期:2012年32-7]
- Starvation, like many other catabolic conditions, induces loss of skeletal muscle mass by promoting fiber atrophy. In addition to the canonical processes, the starvation-induced response employs many distinct pathways th...
- Viral Factors Reveal a Role for REF/Aly in Nuclear RNA Stability
[作者:Stubbs, SH; Hunter, OV; Hoover, A; Conrad, NK,期刊:Molecular and Cellular Biology, 页码:1260-1270 , 文章类型: Article,,卷期:2012年32-7]
- TREX is a conserved multiprotein complex that is necessary for efficient mRNA export to the cytoplasm. In Saccharomyces cerevisiae, the TREX complex is additionally implicated in RNA quality control pathways, but it is u...
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