个性化文献订阅>文章检索

文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共67条记录   EGF-induced Grb7 Recruits and Promotes Ras Activity Essential for the Tumorigenicity of Sk-Br3 Breast Cancer Cells [作者：Chu, PY; Li, TK; Ding, ST; Lai, IR; Shen, TL,期刊：Journal of Biological Chemistry, 页码：29279-29285 , 文章类型： Article，,卷期：2010年285-38] Co-amplification and co-overexpression of ErbB2 and Grb7 are frequently found in various cancers, including breast cancer. Biochemical and functional correlations of the two molecules have identified Grb7 to be a pivotal... A Minimal Cysteine Motif Required to Activate the SKOR K+ Channel of Arabidopsis by the Reactive Oxygen Species H2O2 [作者：Garcia-Mata, C; Wang, JW; Gajdanowicz, P; Gonzalez, W; Hills, A; Donald, N; Riedelsberger, J; Amtmann, A; Dreyer, I; Blatt, MR,期刊：Journal of Biological Chemistry, 页码：29286-29294 , 文章类型： Article，,卷期：2010年285-38] Reactive oxygen species (ROS) are essential for development and stress signaling in plants. They contribute to plant defense against pathogens, regulate stomatal transpiration, and influence nutrient uptake and partition... Dominant Negative Effects of a Non-conducting TREK1 Splice Variant Expressed in Brain [作者：Veale, EL; Rees, KA; Mathie, A; Trapp, S,期刊：Journal of Biological Chemistry, 页码：29295-29304 , 文章类型： Article，,卷期：2010年285-38] Two-pore domain potassium (K-2P) channels modulate neuronal excitability throughout the entire CNS. The stretch-activated channel TREK1 (K(2P)2.1) is expressed widely in brain and has been linked to depression, neuroprot... RosR (Cg1324), a Hydrogen Peroxide-sensitive MarR-type Transcriptional Regulator of Corynebacterium glutamicum [作者：Bussmann, M; Baumgart, M; Bott, M,期刊：Journal of Biological Chemistry, 页码：29305-29318 , 文章类型： Article，,卷期：2010年285-38] The cg1324 gene (rosR) of Corynebacterium glutamicum encodes a MarR-type transcriptional regulator. By a comparative transcriptome analysis with DNA microarrays of a Delta rosR mutant and the wild type and subsequent EMS... Contribution of the Peroxisomal acox Gene to the Dynamic Balance of Daumone Production in Caenorhabditis elegans [作者：Joo, HJ; Kim, KY; Yim, YH; Jin, YX; Kim, H; Kim, MY; Paik, YK,期刊：Journal of Biological Chemistry, 页码：29319-29325 , 文章类型： Article，,卷期：2010年285-38] Dauer pheromones or daumones, which are signaling molecules that interrupt development and reproduction (dauer larvae) during unfavorable growth conditions, are essential for cellular homeostasis in Caenorhabditis elegan... Identification of Two APOBEC3F Splice Variants Displaying HIV-1 Antiviral Activity and Contrasting Sensitivity to Vif [作者：Lassen, KG; Wissing, S; Lobritz, MA; Santiago, M; Greene, WC,期刊：Journal of Biological Chemistry, 页码：29326-29335 , 文章类型： Article，,卷期：2010年285-38] Approximately half of all human genes undergo alternative mRNA splicing. This process often yields homologous gene products exhibiting diverse functions. Alternative splicing of APOBEC3G (A3G) and APOBEC3F (A3F), the maj... Mechanical Stretch Up-regulates MicroRNA-26a and Induces Human Airway Smooth Muscle Hypertrophy by Suppressing Glycogen Synthase Kinase-3 beta [作者：Mohamed, JS; Lopez, MA; Boriek, AM,期刊：Journal of Biological Chemistry, 页码：29336-29347 , 文章类型： Article，,卷期：2010年285-38] Airway smooth muscle hypertrophy is one of the hallmarks of airway remodeling in severe asthma. Several human diseases have been now associated with dysregulated microRNA (miRNA) expression. miRNAs are a class of small n... Control of Translation Initiation through Integration of Signals Generated by Hormones, Nutrients, and Exercise [作者：Kimball, SR; Jefferson, LS,期刊：Journal of Biological Chemistry, 页码：29027-29032 , 文章类型： Review，,卷期：2010年285-38] Control of translation initiation in a tissue of an intact mammalian organism is a highly complex process requiring the continuous integration of multiple positive and negative stimuli. For a tissue such as skeletal musc... Alternative Ways to Think about Cellular Internal Ribosome Entry [作者：Gilbert, WV,期刊：Journal of Biological Chemistry, 页码：29033-29038 , 文章类型： Review，,卷期：2010年285-38] Internal ribosome entry sites (IRESs) are specialized mRNA elements that allow recruitment of eukaryotic ribosomes to naturally uncapped mRNAs or to capped mRNAs under conditions in which cap-dependent translation is inh... Smad2 Positively Regulates the Generation of Th17 Cells [作者：Martinez, GJ; Zhang, ZM; Reynolds, JM; Tanaka, S; Chung, Y; Liu, T; Robertson, E; Lin, X; Feng, XH; Dong, C,期刊：Journal of Biological Chemistry, 页码：29039-29043 , 文章类型： Article，,卷期：2010年285-38] Development of Foxp3(+) regulatory T cells and pro-inflammatory Th17 cells from naive CD4(+) T cells requires transforming growth factor-beta (TGF-beta) signaling. Although Smad4 and Smad3 have been previously shown to r... SMAD2 Is Essential for TGF beta-mediated Th17 Cell Generation [作者：Malhotra, N; Robertson, E; Kang, J,期刊：Journal of Biological Chemistry, 页码：29044-29048 , 文章类型： Article，,卷期：2010年285-38] TGF beta is the quintessential cytokine of T cell homeostasis. TGF beta signaling is required for the efficient differentiation and maintenance of CD4(+)FOXP3(+) T cells that inhibit immune responses. Conversely, in conj... Only One ATP-binding DnaX Subunit Is Required for Initiation Complex Formation by the Escherichia coli DNA Polymerase III Holoenzyme [作者：Wieczorek, A; Downey, CD; Dallmann, HG; McHenry, CS,期刊：Journal of Biological Chemistry, 页码：29049-29053 , 文章类型： Article，,卷期：2010年285-38] The DnaX complex (DnaX(3)delta delta'chi psi) within the Escherichia coli DNApolymerase III holoenzyme serves to load the dimeric sliding clamp processivity factor, beta(2), onto DNA. The complex contains three DnaX subu... A Novel Mechanism for Ribonuclease Regulation TRANSFER-MESSENGER RNA (tmRNA) AND ITS ASSOCIATED PROTEIN SmpB REGULATE THE STABILITY OF RNase R [作者：Liang, WX; Deutscher, MP,期刊：Journal of Biological Chemistry, 页码：29054-29058 , 文章类型： Article，,卷期：2010年285-38] The amount of RNase R, an important degradative exoribonuclease, increases 3-10-fold under a variety of stress conditions. This elevation is due to posttranslational regulation in which the highly unstable RNase R protei... Cross-talk between Serine/Threonine Protein Phosphatase 2A and Protein Tyrosine Phosphatase 1B Regulates Src Activation and Adhesion of Integrin alpha(IIb)beta(3) to Fibrinogen [作者：Pradhan, S; Alrehani, N; Patel, V; Khatlani, T; Vijayan, KV,期刊：Journal of Biological Chemistry, 页码：29059-29068 , 文章类型： Article，,卷期：2010年285-38] Integrin alpha(IIb)beta(3) signaling mediated by kinases and phosphatases participate in hemostasis and thrombosis, in part, by supporting stable platelet adhesion. Our previous studies indicate that the genetic manipula... Sterol Regulatory Element-binding Protein (SREBP)-1-mediated Lipogenesis Is Involved in Cell Senescence [作者：Kim, YM; Shin, HT; Seo, YH; Byun, HO; Yoon, SH; Lee, IK; Hyun, DH; Chung, HY; Yoon, G,期刊：Journal of Biological Chemistry, 页码：29069-29077 , 文章类型： Article，,卷期：2010年285-38] Increased cell mass is one of the characteristics of senescent cells, but this event has not been clearly defined. When subcellular organellar mass was estimated with organelle-specific fluorescence dyes, we observed tha... Alkaline Ceramidase 2 (ACER2) and Its Product Dihydrosphingosine Mediate the Cytotoxicity of N-(4-Hydroxyphenyl)retinamide in Tumor Cells [作者：Mao, ZH; Sun, W; Xu, RJ; Novgorodov, S; Szulc, ZM; Bielawski, J; Obeid, LM; Mao, CG,期刊：Journal of Biological Chemistry, 页码：29078-29090 , 文章类型： Article，,卷期：2010年285-38] Increased generation of dihydrosphingosine (DHS), a bioactive sphingolipid, has been implicated in the cytotoxicity of the synthetic retinoid N-(4-hydroxyphenyl)retinamide (4-HPR) in tumor cells. However, how 4-HPR incre...