- Lipidization of human interferon-alpha: A new approach toward improving the delivery of protein drugs
[作者:Yuan, L; Wang, J; Shen, WC,期刊:Journal of controlled release, 页码:11-17 , 文章类型: Article,,卷期:2008年129-1]
- Human interferon-alpha (IFN-alpha), a 19.2 KD protein containing two disulfide bonds (cys1-cys98; cys29-cys138), was reduced and modified with a reversible lipidization agent. The product of the lipidization, PAL-IFN, wa...
- A potential target associated with both cancer and cancer stem cells: A combination therapy for eradication of breast cancer using vinorelbine stealthy liposomes plus parthenolide stealthy liposomes
[作者:Liu, Y; Lu, WL; Guo, J; Du, J; Li, T; Wu, JW; Wang, GL; Wang, JC; Zhang, X; Zhang, Q,期刊:Journal of controlled release, 页码:18-25 , 文章类型: Article,,卷期:2008年129-1]
- The cancer stem cells play a critical role in both initiation and relapse of the cancers as they are resistant to the most of cytotoxic agents and able to proliferate indefinitely. Vinorelbine stealthy liposomes and part...
- Oligomannose-coated liposomes as a therapeutic antigen-delivery and an adjuvant vehicle for induction of in vivo tumor immunity
[作者:Kojima, N; Biao, L; Nakayama, T; Ishii, M; Ikehara, Y; Tsujimura, K,期刊:Journal of controlled release, 页码:26-32 , 文章类型: Article,,卷期:2008年129-1]
- In the present study, the adjuvant capacity of oligomannose-coated liposomes (OMLs) was evaluated in mice, and an OML-based vaccine was shown to induce effective anti-tumor immunity. C57BL/6 mice were immunized subcutane...
- Formulation of a geldanamycin prodrug in mPEG-b-PCL micelles greatly enhances tolerability and pharmacokinetics in rats
[作者:Xiong, MP; Yanez, JA; Remsberg, CM; Ohgami, Y; Kwon, GS; Davies, NM; Forrest, ML,期刊:Journal of controlled release, 页码:33-40 , 文章类型: Article,,卷期:2008年129-1]
- Geldanamycin (GA) and its analogues inhibit heat shock protein 90 (Hsp90) and have shown significant antitumor activity in vivo; however, clinical development of GA has been hampered by its poor solubility and severe hep...
- Characterization of water-in-oil microemulsion for oral delivery of earthworm fibrinolytic enzyme
[作者:Cheng, MB; Wang, JC; Li, YH; Liu, XY; Zhang, X; Chen, DW; Zhou, SF; Zhang, Q,期刊:Journal of controlled release, 页码:41-48 , 文章类型: Article,,卷期:2008年129-1]
- Earthworm fibrinolytic enzyme (EFE-d, Mr 24177), a water-soluble protein, is clinically used for the management of cardiovascular diseases. However, this protein drug has a very low oral bioavailability because of its lo...
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