- Hormone replacement therapy and incidence of central nervous system tumours in the Million Women Study
[作者:Benson, VS; Pine, K; Green, J; Bull, D; Casabonne, D; Reeves, GK; Beral, V,期刊:International Journal of Cancer, 页码:1692-1698 , 文章类型: Article,,卷期:2010年127-7]
- We examined the relation between the use of hormone replacement therapy (HRT) and the incidence of central nervous system (CNS) tumours in a large prospective study of 1,147,894 postmenopausal women. Women were aged 56.6...
- Results of the three rounds of the Finnish Prostate Cancer Screening Trial-the incidence of advanced cancer is decreased by screening
[作者:Kilpelainen, TP; Auvinen, A; Maattanen, L; Kujala, P; Ruutu, M; Stenman, UH; Tammela, TLJ,期刊:International Journal of Cancer, 页码:1699-1705 , 文章类型: Article,,卷期:2010年127-7]
- Screening for prostate cancer (PC) remains a controversial issue despite some new evidence on the mortality benefits of PC screening. We conducted a prospective, randomized screening trial in Finland to investigate wheth...
- Muscle atrophy in experimental cancer cachexia: is the IGF-1 signaling pathway involved?
[作者:Penna, F; Bonetto, A; Muscaritoli, M; Costamagna, D; Minero, VG; Bonelli, G; Fanelli, FR; Baccino, FM; Costelli, P,期刊:International Journal of Cancer, 页码:1706-1717 , 文章类型: Article,,卷期:2010年127-7]
- Skeletal muscle wasting, one of the main features of cancer cachexia, is associated with marked protein hypercatabolism, and has suggested to depend also on impaired IGF-1 signal transduction pathway. To investigate this...
- Anti-breast cancer potential of SS1020, a novel antiestrogen lacking estrogenic and genotoxic actions
[作者:Laxmi, YRS; Liu, XP; Suzuki, N; Kim, SY; Okamoto, K; Kim, HJ; Zhang, GX; Chen, JJ; Okamoto, Y; Shibutani, S,期刊:International Journal of Cancer, 页码:1718-1726 , 文章类型: Article,,卷期:2010年127-7]
- Long-term treatment with tamoxifen (TAM) increases the risk of developing endometrial cancer in women. Several antiestrogens developed in last decades have been discontinued from clinical testing because of their undesir...
- Optimized nanosecond pulsed electric field therapy can cause murine malignant melanomas to self-destruct with a single treatment
[作者:Nuccitelli, R; Tran, K; Sheikh, S; Athos, B; Kreis, M; Nuccitelli, P,期刊:International Journal of Cancer, 页码:1727-1736 , 文章类型: Article,,卷期:2010年127-7]
- We have identified a new, nanosecond pulsed electric field (nsPEF) therapy capable of eliminating murine melanomas located in the skin with a single treatment. When these optimized parameters are used nsPEFs initiate apo...
- RNAi-mediated downregulation of uPAR synergizes with targeting of HER2 through the ERK pathway in breast cancer cells
[作者:Li, CF; Cao, S; Liu, Z; Ye, X; Chen, LZ; Meng, SD,期刊:International Journal of Cancer, 页码:1507-1516 , 文章类型: Article,,卷期:2010年127-7]
- Overexpression of urokinase plasminogen activator receptor (uPAR) or HER2 (erbB-2) in breast cancer is associated with a poor prognosis. We previously reported that gene amplification and overexpression of HER2 and uPAR ...
- Reduction of transforming growth factor-beta type II receptor is caused by the enhanced ubiquitin-dependent degradation in human renal cell carcinoma
[作者:Fukasawa, H; Yamamoto, T; Fujigaki, Y; Misaki, T; Ohashi, N; Takayama, T; Suzuki, S; Mugiya, S; Oda, T; Uchida, C; Kitagawa, K; Hattori, T; Hayashi, H; Ozono, S; Kitagawa, M; Hishida, A,期刊:International Journal of Cancer, 页码:1517-1525 , 文章类型: Article,,卷期:2010年127-7]
- Although dysregulation of transforming growth factor-beta (TGF-beta) signalling is implicated in renal carcinogenesis, its precise mechanism is unknown in renal cell carcinoma (RCC) in our study, we investigated Smad-med...
- Tumors exposed to acute cyclic hypoxic stress show enhanced angiogenesis, perfusion and metastatic dissemination
[作者:Rofstad, EK; Gaustad, JV; Egeland, TAM; Mathiesen, B; Galappathi, K,期刊:International Journal of Cancer, 页码:1535-1546 , 文章类型: Article,,卷期:2010年127-7]
- Clinical studies have shown that patients with highly hypoxic primary tumors may have poor disease-free and overall survival rates. Studies of experimental tumors have revealed that acutely hypoxic cells may be more meta...
- Genetic polymorphisms of MPO, GSTT1, GSTM1, GSTP1, EPHX1 and NQO1 as risk factors of early-onset lung cancer
[作者:Timofeeva, M; Kropp, S; Sauter, W; Beckmann, L; Rosenberger, A; Illig, T; Jager, B; Mittelstrass, K; Dienemann, H; Bartsch, H; Bickeboller, H; Chang-Claude, J; Risch, A; Wichmann, HE,期刊:International Journal of Cancer, 页码:1547-1561 , 文章类型: Article,,卷期:2010年127-7]
- Early-onset lung cancer diagnosed up to the age of 50 is a very rare disease, with an increasing incidence rate. Differences in aetiology, characteristics and epidemiology of early and older onset lung cancer have been d...
- Macroscopic morphologic subtypes of laterally spreading colorectal tumors showing distinct molecular alterations
[作者:Sugimoto, T; Ohta, M; Ikenoue, T; Yamada, A; Tada, M; Fujishiro, M; Ogura, K; Yamaji, Y; Okamoto, M; Kanai, F; Kawabe, T; Omata, M,期刊:International Journal of Cancer, 页码:1562-1569 , 文章类型: Article,,卷期:2010年127-7]
- Recent advances in colonoscopic techniques have resulted in more frequent detection of superficial-type colorectal tumors, that is, laterally spreading tumors (LSTs), although little is known about the characteristic cli...
- Epstein-Barr virus infection in immortalized nasopharyngeal epithelial cells: regulation of infection and phenotypic characterization
[作者:Tsang, CM; Zhang, GT; Seto, E; Takada, K; Deng, W; Yip, YL; Man, C; Hau, PM; Chen, HL; Cao, Y; Lo, KW; Middeldorp, JM; Cheung, ALM; Tsao, SW,期刊:International Journal of Cancer, 页码:1570-1583 , 文章类型: Article,,卷期:2010年127-7]
- Epstein-Barr virus (EBV) infection has been postulated to be an early event involved in the pathogenesis of nasopharyngeal carcinomas (NPC). The lack of representative premalignant nasopharyngeal epithelial cell system f...
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