- Aging-related alterations in the extracellular matrix modulate the microenvironment and influence tumor progression
[作者:Sprenger, CC; Plymate, SR; Reed, MJ,期刊:International Journal of Cancer, 页码:2739-2748 , 文章类型: Article,,卷期:2010年127-12]
- Age is the greatest risk factor for the development of epithelial cancers. In this minireview, we will examine key extracellular matrix and matricellular components, their changes with aging, and discuss how these altera...
- Protective role of 17 beta-estradiol on medulloblastoma development in Patched1 heterozygous mice
[作者:Mancuso, M; Leonardi, S; Ceccarelli, M; Pasquali, E; De Stefano, I; Prisco, MG; Rebessi, S; Tanori, M; Scambia, G; Di Majo, V; Pazzaglia, S; Saran, A; Gallo, D,期刊:International Journal of Cancer, 页码:2749-2757 , 文章类型: Article,,卷期:2010年127-12]
- Medulloblastoma (MB) is the most common pediatric tumor of the CNS, representing similar to 20% of all childhood CNS tumors. Although in recent years many molecular mechanisms that control MB development have been clarif...
- Adiponectin and adiponectin receptor in relation to colorectal cancer progression
[作者:Byeon, JS; Jeong, JY; Kim, MJ; Lee, SM; Nam, WH; Myung, SJ; Kim, JG; Yang, SK; Kim, JH; Suh, DJ,期刊:International Journal of Cancer, 页码:2758-2767 , 文章类型: Article,,卷期:2010年127-12]
- Although obesity is a risk factor for colorectal cancer, the underlying mechanism is not clear. Adiponectin is an adipokine that binds to 2 types of receptors, AdipoR1 and AdipoR2. The plasma concentrations of adiponecti...
- miR-34c is downregulated in prostate cancer and exerts tumor suppressive functions
[作者:Hagman, Z; Larne, O; Edsjo, A; Bjartell, A; Ehrnstrom, RA; Ulmert, D; Lilja, H; Ceder, Y,期刊:International Journal of Cancer, 页码:2768-2776 , 文章类型: Article,,卷期:2010年127-12]
- MicroRNAs (miRNAs) are small noncoding RNAs that post-transcriptionally regulate gene expression. There have been several reports of miRNA deregulation in prostate cancer (PCa) and the biological evidence for an involvem...
- Depletion of the human N-alpha-terminal acetyltransferase A induces p53-dependent apoptosis and p53-independent growth inhibition
[作者:Gromyko, D; Arnesen, T; Ryningen, A; Varhaug, JE; Lillehaug, JR,期刊:International Journal of Cancer, 页码:2777-2789 , 文章类型: Article,,卷期:2010年127-12]
- The human protein N-alpha-terminal acetyltransferase A complex (hNatA), composed of the catalytic hNaa10p (hArd1) and auxiliary hNaa15p (hNat1/NATH/Tubedown) subunits, was reported to be important for cell survival and g...
- Concomitant inhibition of AKT and autophagy is required for efficient cisplatin-induced apoptosis of metastatic skin carcinoma
[作者:Claerhout, S; Verschooten, L; Van Kelst, S; De Vos, R; Proby, C; Agostinis, P; Garmyn, M,期刊:International Journal of Cancer, 页码:2790-2803 , 文章类型: Article,,卷期:2010年127-12]
- Cutaneous squamous cell carcinoma (cSCC) is one of the most common cancers in the Caucasian population. Although early stages of skin cancer have a high curability and excellent prognosis, advanced cSCC shows resistance ...
- miR-145, miR-133a and miR-133b: tumor-suppressive miRNAs target FSCN1 in esophageal squamous cell carcinoma
[作者:Kano, M; Seki, N; Kikkawa, N; Fujimura, L; Hoshino, I; Akutsu, Y; Chiyomaru, T; Enokida, H; Nakagawa, M; Matsubara, H,期刊:International Journal of Cancer, 页码:2804-2814 , 文章类型: Article,,卷期:2010年127-12]
- MicroRNAs (miRNAs), noncoding RNAs 21-25 nucleotides in length, regulate gene expression primarily at the posttranscriptional level. Growing evidence suggests that miRNAs are aberrantly expressed in many human cancers, a...
- Genetic polymorphism in the conjugating enzyme UGT1A1 and the risk of head and neck cancer
[作者:Lacko, M; Roelofs, HMJ; Morsche, RHMT; Voogd, AC; Ophuis, MBO; Peters, WHM; Manni, JJ,期刊:International Journal of Cancer, 页码:2815-2821 , 文章类型: Article,,卷期:2010年127-12]
- UDP-glucuronosyltransferase 1A1 (UGT1A1) is an enzyme which catalyses not only the glucuronidation of tobacco smoke carcinogens like benzopyrene, but also of the endogenous substrate bilirubin. Bilirubin for a long time ...
- Polymorphisms in inflammatory pathway genes and their association with colorectal cancer risk
[作者:Frank, B; Hoffmeister, M; Klopp, N; Illig, T; Chang-Claude, J; Brenner, H,期刊:International Journal of Cancer, 页码:2822-2830 , 文章类型: Article,,卷期:2010年127-12]
- Chronic inflammation is an established risk factor for colorectal cancer (CRC), and polymorphisms in genes regulating inflammatory processes appear to alter the risk for neoplasia and the efficacy of nonsteroidal anti-in...
- Imiquimod-induced clearance of HPV is associated with normalization of immune cell counts in usual type vulvar intraepithelial neoplasia
[作者:Terlou, A; van Seters, M; Kleinjan, A; Heijmans-Antonissen, C; Santegoets, LAM; Beckmann, I; van Beurden, M; Helmerhorst, TJM; Blok, LJ,期刊:International Journal of Cancer, 页码:2831-2840 , 文章类型: Article,,卷期:2010年127-12]
- Recently, we reported on the efficacy of imiquimod for treatment of usual type vulvar intraepithelial neoplasia (uVIN). A histologic regression of uVIN to normal tissue was observed in 58% of patients. As success of trea...
- A metabonomic approach to chemosensitivity prediction of cisplatin plus 5-fluorouracil in a human xenograft model of gastric cancer
[作者:Wang, X; Yan, SK; Dai, WX; Liu, XR; Zhang, WD; Wang, JJ,期刊:International Journal of Cancer, 页码:2841-2850 , 文章类型: Article,,卷期:2010年127-12]
- The prediction of chemosensitivity is a challenging problem in the management of cancer. In the present study, a metabonomic approach was proposed to assess the feasibility of chemosensitivity prediction in a human xenog...
- p27(Kip1) is a predictive factor for tamoxifen treatment response but not a prognostic marker in premenopausal breast cancer patients
[作者:Stendahl, M; Nilsson, S; Wigerup, C; Jirstrom, K; Jonsson, PE; Stal, O; Landberg, G,期刊:International Journal of Cancer, 页码:2851-2858 , 文章类型: Article,,卷期:2010年127-12]
- The cell-cycle regulating protein p27(Kip1) (p27) has dual roles by acting as both a cdk inhibitor and as an assembly factor for different cdk complexes. Loss of p27 has been linked to malignant features in tumours; howe...
- Downregulated microRNAs in the differential diagnosis of malignant pleural mesothelioma
[作者:Gee, GV; Koestler, DC; Christensen, BC; Sugarbaker, DJ; Ugolini, D; Ivaldi, GP; Resnick, MB; Houseman, EA; Kelsey, KT; Marsit, CJ,期刊:International Journal of Cancer, 页码:2859-2869 , 文章类型: Article,,卷期:2010年127-12]
- Malignant pleural mesothelioma (MPM) is a rapidly fatal disease whose diagnosis, particularly through less invasive techniques such as analysis of pleural effusion, can be challenging. Currently, a commercially available...
- Early detection of lung adenocarcinoma in sputum by a panel of microRNA markers
[作者:Yu, L; Todd, NW; Xing, LX; Xie, Y; Zhang, H; Liu, ZQ; Fang, HB; Zhang, JA; Katz, RL; Jiang, F,期刊:International Journal of Cancer, 页码:2870-2878 , 文章类型: Article,,卷期:2010年127-12]
- Adenocarcinoma is the most common type of lung cancer, the leading cause of cancer deaths in the world. Early detection is the key to improve the survival of lung adenocarcinoma patients. We have previously shown that mi...
- Hospitalizations among children of survivors of childhood and adolescent cancer: a population-based cohort study
[作者:Winther, JF; Boice, JD; Christensen, J; Frederiksen, K; Mulvihill, JJ; Stovall, M; Olsen, JH,期刊:International Journal of Cancer, 页码:2879-2887 , 文章类型: Article,,卷期:2010年127-12]
- Curative but potentially mutagenic cancer therapy might lead to untoward disorders and increased hospitalization among the offspring of childhood cancer survivors. Hospitalizations in childhood were evaluated in a popula...
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