- Contribution of a TANK-Binding Kinase 1-Interferon (IFN) Regulatory Factor 7 Pathway to IFN-gamma-Induced Gene Expression
[作者:Farlik, M; Rapp, B; Marie, I; Levy, DE; Jamieson, AM; Decker, T,期刊:Molecular and Cellular Biology, 页码:1032-1043 , 文章类型: Article,,卷期:2012年32-6]
- Signal transducers and activators of transcription (STATs) and interferon regulatory factors (IRFs) share common target genes. Here we show that the Irf7 gene is regulated by transcription factors STAT1 and IRF9 in respo...
- Dynamic Loss of H2B Ubiquitylation without Corresponding Changes in H3K4 Trimethylation during Myogenic Differentiation
[作者:Vethantham, V; Yang, Y; Bowman, C; Asp, P; Lee, JH; Skalnik, DG; Dynlacht, BD,期刊:Molecular and Cellular Biology, 页码:1044-1055 , 文章类型: Article,,卷期:2012年32-6]
- Ubiquitylation of H2B on lysine 120 (H2Bub) is associated with active transcriptional elongation. H2Bub has been implicated in histone cross talk and is generally regarded to be a prerequisite for trimethylation of histo...
- CD2AP Regulates SUMOylation of CIN85 in Podocytes
[作者:Tossidou, I; Niedenthal, R; Klaus, M; Teng, BN; Worthmann, K; King, BL; Peterson, KJ; Haller, H; Schiffer, M,期刊:Molecular and Cellular Biology, 页码:1068-1079 , 文章类型: Article,,卷期:2012年32-6]
- Podocytes are highly differentiated and polarized epithelial cells located on the visceral side of the glomerulus. They form an indispensable component of the glomerular filter, the slit diaphragm, formed by several tran...
- Berardinelli-Seip Congenital Lipodystrophy 2/Seipin Is a Cell-Autonomous Regulator of Lipolysis Essential for Adipocyte Differentiation
[作者:Chen, WQ; Chang, B; Saha, P; Hartig, SM; Li, L; Reddy, VT; Yang, YS; Yechoor, V; Mancini, MA; Chan, L,期刊:Molecular and Cellular Biology, 页码:1099-1111 , 文章类型: Article,,卷期:2012年32-6]
- Mutations in BSCL2 underlie human congenital generalized lipodystrophy. We inactivated Bscl2 in mice to examine the mechanisms whereby absence of Bscl2 leads to adipose tissue loss and metabolic disorders. Bscl2(-/-) mic...
- Identification of an AAA ATPase VPS4B-Dependent Pathway That Modulates Epidermal Growth Factor Receptor Abundance and Signaling during Hypoxia
[作者:Lin, HH; Li, X; Chen, JL; Sun, XZ; Cooper, FN; Chen, YR; Zhang, WY; Chung, YY; Li, A; Cheng, CT; Yang, LX; Deng, XT; Liu, XY; Yen, Y; Johnson, DL; Shih, HM; Yang, A; Ann, DK,期刊:Molecular and Cellular Biology, 页码:1124-1138 , 文章类型: Article,,卷期:2012年32-6]
- VPS4B, an AAA ATPase (ATPase associated with various cellular activities), participates in vesicular trafficking and autophagosome maturation in mammalian cells. In solid tumors, hypoxia is a common feature and an indica...
- RYBP Represses Endogenous Retroviruses and Preimplantation- and Germ Line-Specific Genes in Mouse Embryonic Stem Cells
[作者:Hisada, K; Sanchez, C; Endo, TA; Endoh, M; Roman-Trufero, M; Sharif, J; Koseki, H; Vidal, M,期刊:Molecular and Cellular Biology, 页码:1139-1149 , 文章类型: Article,,卷期:2012年32-6]
- Polycomb repressive complexes (PRCs) are important chromatin regulators of embryonic stem (ES) cell function. RYBP binds Polycomb H2A monoubiquitin ligases Ring1A and Ring1B and has been suggested to assist PRC localizat...
- Sam50 Functions in Mitochondrial Intermembrane Space Bridging and Biogenesis of Respiratory Complexes
[作者:Ott, C; Ross, K; Straub, S; Thiede, B; Gotz, M; Goosmann, C; Krischke, M; Mueller, MJ; Krohne, G; Rudel, T; Kozjak-Pavlovic, V,期刊:Molecular and Cellular Biology, 页码:1173-1188 , 文章类型: Article,,卷期:2012年32-6]
- Mitochondria possess an outer membrane (OMM) and an inner membrane (IMM), which folds into invaginations called cristae. Lipid composition, membrane potential, and proteins in the IMM influence organization of cristae. H...
- RNA Profiling and Chromatin Immunoprecipitation-Sequencing Reveal that PTF1a Stabilizes Pancreas Progenitor Identity via the Control of MNX1/HLXB9 and a Network of Other Transcription Factors
[作者:Thompson, N; Gesina, E; Scheinert, P; Bucher, P; Grapin-Botton, A,期刊:Molecular and Cellular Biology, 页码:1189-1199 , 文章类型: Article,,卷期:2012年32-6]
- Pancreas development is initiated by the specification and expansion of a small group of endodermal cells. Several transcription factors are crucial for progenitor maintenance and expansion, but their interactions and th...
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