- Desmoglein 3-specific CD4(+) T cells induce pemphigus vulgaris and interface dermatitis in mice
[作者:Takahashi, H; Kouno, M; Nagao, K; Wada, N; Hata, T; Nishimoto, S; Iwakura, Y; Yoshimura, A; Yamada, T; Kuwana, M; Fujii, H; Koyasu, S; Amagai, M,期刊:Journal of clinical investigation, 页码:3677-3688 , 文章类型: Article,,卷期:2011年121-9]
- Pemphigus vulgaris (PV) is a severe autoimmune disease involving blistering of the skin and mucous membranes. It is caused by autoantibodies against desmoglein 3 (Dsg3), an adhesion molecule critical for maintaining epit...
- Enhancement of proteasomal function protects against cardiac proteinopathy and ischemia/reperfusion injury in mice
[作者:Li, J; Horak, KM; Su, HB; Sanbe, A; Robbins, J; Wang, XJ,期刊:Journal of clinical investigation, 页码:3689-3700 , 文章类型: Article,,卷期:2011年121-9]
- The ubiquitin-proteasome system degrades most intracellular proteins, including misfolded. proteins. Proteasome functional insufficiency (PFI) has been observed in proteinopathies, such as desmin-related cardiomyopathy, ...
- Parkin is a lipid-responsive regulator of fat uptake in mice and mutant human cells
[作者:Kim, KY; Stevens, MV; Akter, MH; Rusk, SE; Huang, RJ; Cohen, A; Noguchi, A; Springer, D; Bocharov, AV; Eggerman, TL; Suen, DF; Youle, RJ; Amar, M; Remaley, AT; Sack, MN,期刊:Journal of clinical investigation, 页码:3701-3712 , 文章类型: Article,,卷期:2011年121-9]
- It has long been hypothesized that abnormalities in lipid biology contribute to degenerative brain diseases. Consistent with this, emerging epidemiologic evidence links lipid alterations with Parkinson disease (PD), and ...
- Brain insulin action augments hepatic glycogen synthesis without suppressing glucose production or gluconeogenesis in dogs
[作者:Ramnanan, CJ; Saraswathi, V; Smith, MS; Donahue, EP; Farmer, B; Farmer, TD; Neal, D; Williams, PE; Lautz, M; Mari, A; Cherrington, AD; Edgerton, DS,期刊:Journal of clinical investigation, 页码:3713-3723 , 文章类型: Article,,卷期:2011年121-9]
- In rodents, acute brain insulin action reduces blood glucose levels by suppressing the expression of enzymes in the hepatic gluconeogenic pathway, thereby reducing gluconeogenesis and endogenous glucose production (EGP)....
- Farnesoid X receptor represses hepatic human APOA gene expression
[作者:Chennamsetty, I; Claudel, T; Kostner, KM; Baghdasaryan, A; Kratky, D; Levak-Frank, S; Frank, S; Gonzalez, FJ; Trauner, M; Kostner, GM,期刊:Journal of clinical investigation, 页码:3724-3734 , 文章类型: Article,,卷期:2011年121-9]
- High plasma concentrations of lipoprotein(a) [Lp(a), which is encoded by the APOA gene] increase an individual's risk of developing diseases, such as coronary artery diseases, restenosis, and stroke. Unfortunately, incre...
- Disruption of PPAR gamma/beta-catenin-mediated regulation of apelin impairs BMP-induced mouse and human pulmonary arterial EC survival
[作者:Alastalo, TP; Li, ML; Perez, VD; Pham, D; Sawada, H; Wang, JK; Koskenvuo, M; Wang, LL; Freeman, BA; Chang, HY; Rabinovitch, M,期刊:Journal of clinical investigation, 页码:3735-3746 , 文章类型: Article,,卷期:2011年121-9]
- Reduced bone morphogenetic protein receptor 2 (BMPR2) expression in patients with pulmonary arterial hypertension (PAH) can impair pulmonary arterial EC (PAEC) function. This can adversely affect EC survival and promote ...
- A noninhibitory mutant of the caveolin-1 scaffolding domain enhances eNOS-derived NO synthesis and vasodilation in mice
[作者:Bernatchez, P; Sharma, A; Bauer, PM; Marin, E; Sessa, WC,期刊:Journal of clinical investigation, 页码:3747-3755 , 文章类型: Article,,卷期:2011年121-9]
- Aberrant regulation of eNOS and associated NO release are directly linked with various vascular diseases. Caveolin-1 (Cav-1), the main coat protein of caveolae, is highly expressed in endothelial cells. Its scaffolding d...
- Glycogen synthase kinase-3 is essential for beta-arrestin-2 complex formation and lithium-sensitive behaviors in mice
[作者:O'Brien, WT; Huang, J; Buccafusca, R; Garskof, J; Valvezan, AJ; Berry, GT; Klein, PS,期刊:Journal of clinical investigation, 页码:3756-3762 , 文章类型: Article,,卷期:2011年121-9]
- Lithium is the first-line therapy for bipolar disorder. However, its therapeutic target remains controversial. Candidates include inositol monophosphatases, glycogen synthase kinase-3 (GSK-3), and a beta-arrestin-2/AKT/p...
- Prolactin increases SMN expression and survival in a mouse model of severe spinal muscular atrophy via the STAT5 pathway (vol 12, pg 3042, 2011)
[作者:Farooq, F; Molina, FA; Hadwen, J; MacKenzie, D; Witherspoon, L; Osmond, M; Holcik, M; MacKenzie, A,期刊:Journal of clinical investigation, 页码:3763-3763 , 文章类型: Correction,,卷期:2011年121-9]
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