- Inflammatory dendritic cells migrate in and out of transplanted chronic mycobacterial granulomas in mice
[作者：Schreiber, HA; Harding, JS; Hunt, O; Altamirano, CJ; Hulseberg, PD; Stewart, D; Fabry, Z; Sandor, M,期刊：Journal of clinical investigation, 页码：3902-3913 , 文章类型： Article，,卷期：2011年121-10]
- An estimated one-third of the world's population is infected with Mycobacterium tuberculosis, although most affected individuals maintain a latent infection. This control is attributed to the formation of granulomas, cel...
- Nitisinone improves eye and skin pigmentation defects in a mouse model of oculocutaneous albinism
[作者：Onojafe, IF; Adams, DR; Simeonov, DR; Zhang, J; Chan, CC; Bernardini, IM; Sergeev, YV; Dolinska, MB; Alur, RP; Brilliant, MH; Gahl, WA; Brooks, BP,期刊：Journal of clinical investigation, 页码：3914-3923 , 文章类型： Article，,卷期：2011年121-10]
- Mutation of the tyrosinase gene (TYR) causes oculocutaneous albinism, type 1 (OCA1), a condition characterized by reduced skin and eye melanin pigmentation and by vision loss. The retinal pigment epithelium influences po...
- Cerebral amyloid-beta proteostasis is regulated by the membrane transport protein ABCC1 in mice
[作者：Krohn, M; Lange, C; Hofrichter, J; Scheffler, K; Stenzel, J; Steffen, J; Schumacher, T; Bruning, T; Plath, AS; Alfen, F; Schmidt, A; Winter, F; Rateitschak, K; Wree, A; Gsponer, J; Walker, LC; Pahnke, J,期刊：Journal of clinical investigation, 页码：3924-3931 , 文章类型： Article，,卷期：2011年121-10]
- In Alzheimer disease (AD), the intracerebral accumulation of amyloid-beta (A beta) peptides is a critical yet poorly understood process. A beta clearance via the blood-brain barrier is reduced by approximately 30% in AD ...
- IL-6 trans-signaling licenses mouse and human tumor microvascular gateways for trafficking of cytotoxic T cells
[作者：Fisher, DT; Chen, Q; Skitzki, JJ; Muhitch, JB; Zhou, L; Appenheimer, MM; Vardam, TD; Weis, EL; Passanese, J; Wang, WC; Gollnick, SO; Dewhirst, MW; Rose-John, S; Repasky, EA; Baumann, H; Evans, SS,期刊：Journal of clinical investigation, 页码：3846-3859 , 文章类型： Article，,卷期：2011年121-10]
- Immune cells are key regulators of neoplastic progression, which is often mediated through their release of cytokines. Inflammatory cytokines such as IL-6 exert tumor-promoting activities by driving growth and survival o...
- T cell killing by tolerogenic dendritic cells protects mice from allergy
[作者：Luckey, U; Maurer, M; Schmidt, T; Lorenz, N; Seebach, B; Metz, M; Steinbrink, K,期刊：Journal of clinical investigation, 页码：3860-3871 , 文章类型： Article，,卷期：2011年121-10]
- It is well established that allergy development can be prevented by repeated low-dose exposure to contact allergens. Exactly which immune mechanisms are responsible for this so-called low zone tolerance (LZT) is not clea...
- In vitro insulin secretion by pancreatic tissue from infants with diazoxide-resistant congenital hyperinsulinism deviates from model predictions
[作者：Henquin, JC; Nenquin, M; Sempoux, C; Guiot, Y; Bellanne-Chantelot, C; Otonkoski, T; de Lonlay, P; Nihoul-Fekete, C; Rahier, J,期刊：Journal of clinical investigation, 页码：3932-3942 , 文章类型： Article，,卷期：2011年121-10]
- Congenital hyperinsulinism (CHI) is the major cause of persistent neonatal hypoglycemia. CHI most often occurs due to mutations in the ABCC8 (which encodes sulfonylurea receptor 1) or KCNJ11 (which encodes the potassium ...
- Complement component 5 contributes to poor disease outcome in humans and mice with pneumococcal meningitis
[作者：Woehrl, B; Brouwer, MC; Murr, C; Heckenberg, SGB; Baas, F; Pfister, HW; Zwinderman, AH; Morgan, BP; Barnum, SR; van der Ende, A; Koedel, U; van de Beek, D,期刊：Journal of clinical investigation, 页码：3943-3953 , 文章类型： Article，,卷期：2011年121-10]
- Pneumococcal meningitis is the most common and severe form of bacterial meningitis. Fatality rates are substantial, and long-term sequelae develop in about half of survivors. Disease outcome has been related to the sever...
- Mice overexpressing BAFF develop a commensal flora-dependent, IgA-associated nephropathy
[作者：McCarthy, DD; Kujawa, J; Wilson, C; Papandile, A; Poreci, U; Porfilio, EA; Ward, L; Lawson, MAE; Macpherson, AJ; McCoy, KD; Pei, Y; Novak, L; Lee, JY; Julian, BA; Novak, J; Ranger, A; Gommerman, JL; Browning, JL,期刊：Journal of clinical investigation, 页码：3991-4002 , 文章类型： Article，,卷期：2011年121-10]
- B cell activation factor of the TNF family (BAFF) is a potent B cell survival factor. BAFF overexpressing transgenic mice (BAFF-Tg mice) exhibit features of autoimmune disease, including B cell hyperplasia and hyper-gamm...
- PGC-1 alpha promotes recovery after acute kidney injury during systemic inflammation in mice
[作者：Tran, M; Tam, D; Bardia, A; Bhasin, M; Rowe, GC; Kher, A; Zsengeller, ZK; Akhavan-Sharif, MR; Khankin, EV; Saintgeniez, M; David, S; Burstein, D; Karumanchi, SA; Stillman, IE; Arany, Z; Parikh, SM,期刊：Journal of clinical investigation, 页码：4003-4014 , 文章类型： Article，,卷期：2011年121-10]
- Sepsis-associated acute kidney injury (AM) is a common and morbid condition that is distinguishable from typical ischemic renal injury by its paucity of tubular cell death. The mechanisms underlying renal dysfunction in ...
- Protective antiviral antibody responses in a mouse model of influenza virus infection require TACI
[作者：Wolf, AI; Mozdzanowska, K; Quinn, WJ; Metzgar, M; Williams, KL; Caton, AJ; Meffre, E; Bram, RJ; Erickson, LD; Allman, D; Cancro, MP; Erikson, J,期刊：Journal of clinical investigation, 页码：3954-3964 , 文章类型： Article，,卷期：2011年121-10]
- Antiviral Abs, for example those produced in response to influenza virus infection, are critical for virus neutralization and defense against secondary infection. While the half-life of Abs is short, Ab titers can last a...
- CD2AP in mouse and human podocytes controls a proteolytic program that regulates cytoskeletal structure and cellular survival
[作者：Yaddanapudi, S; Altintas, MM; Kistler, AD; Fernandez, I; Moller, CC; Wei, CL; Peev, V; Flesche, JB; Forst, AL; Li, J; Patrakka, J; Xiao, ZJ; Grahammer, F; Schiffer, M; Lohmuller, T; Reinheckel, T; Gu, CK; Huber, TB; Ju, WJ; Bitzer, M; Rastaldi, MP; Ruiz, P; Tryggvason, K; Shaw, AS; Faul, C; Sever, S; Reiser, J,期刊：Journal of clinical investigation, 页码：3965-3980 , 文章类型： Article，,卷期：2011年121-10]
- Kidney podocytes are highly differentiated epithelial cells that form interdigitating foot processes with bridging slit diaphragms (SDs) that regulate renal ultrafiltration. Podocyte injury results in proteinuric kidney ...
- Dysfunction of fibroblasts of extrarenal origin underlies renal fibrosis and renal anemia in mice
[作者：Asada, N; Takase, M; Nakamura, J; Oguchi, A; Asada, M; Suzuki, N; Yamarnura, K; Nagoshi, N; Shibata, S; Rao, TN; Fehling, HJ; Fukatsu, A; Minegishi, N; Kita, T; Kimura, T; Okano, H; Yamamoto, M; Yanagita, M,期刊：Journal of clinical investigation, 页码：3981-3990 , 文章类型： Article，,卷期：2011年121-10]
- In chronic kidney disease, fibroblast dysfunction causes renal fibrosis and renal anemia. Renal fibrosis is mediated by the accumulation of myofibroblasts, whereas renal anemia is mediated by the reduced production of fi...
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