- Inhibition of PKC delta reduces cisplatin-induced nephrotoxicity without blocking chemotherapeutic efficacy in mouse models of cancer
[作者：Pabla, N; Dong, G; Jiang, M; Huang, S; Kumar, MV; Messing, RO; Dong, Z,期刊：Journal of clinical investigation, 页码：2709-2722 , 文章类型： Article，,卷期：2011年121-7]
- Cisplatin is a widely used cancer therapy drug that unfortunately has major side effects in normal tissues, notably nephrotoxicity in kidneys. Despite intensive research, the mechanism of cisplatin-induced nephrotoxicity...
- Constitutive IKK2 activation in intestinal epithelial cells induces intestinal tumors in mice
[作者：Vlantis, K; Wullaert, A; Sasaki, Y; Schmidt-Supprian, M; Rajewsky, K; Roskams, T; Pasparakis, M,期刊：Journal of clinical investigation, 页码：2781-2793 , 文章类型： Article，,卷期：2011年121-7]
- Many cancers display increased NF-kappa B activity, and NF-kappa B inhibition is known to diminish tumor development in multiple mouse models, supporting an important role of NF-kappa B in carcinogenesis. NF-kappa B acti...
- Ghrelin mediates stress-induced food-reward behavior in mice
[作者：Chuang, JC; Perello, M; Sakata, I; Osborne-Lawrence, S; Savitt, JM; Lutter, M; Zigman, JM,期刊：Journal of clinical investigation, 页码：2684-2692 , 文章类型： Article，,卷期：2011年121-7]
- The popular media and personal anecdotes are rich with examples of stress-induced eating of calorically dense "comfort foods." Such behavioral reactions likely contribute to the increased prevalence of obesity in humans ...
- Absence of IFN-gamma accelerates thrombus resolution through enhanced MMP-9 and VEGF expression in mice
[作者：Nosaka, M; Ishida, Y; Kimura, A; Kuninaka, Y; Inui, M; Mukaida, N; Kondo, T,期刊：Journal of clinical investigation, 页码：2911-2920 , 文章类型： Article，,卷期：2011年121-7]
- Deep vein thrombosis (DVT) is a major cause of pulmonary thromboembolism, a leading cause of death in individuals with DVT. Several lines of evidence indicate proinflammatory cytokines such as TNF-alpha are involved in t...
- Absence of Stat1 in donor CD4(+) T cells promotes the expansion of Tregs and reduces graft-versus-host disease in mice
[作者：Ma, HH; Lu, CS; Ziegler, J; Liu, AL; Sepulveda, A; Okada, H; Lentzsch, S; Mapara, MY,期刊：Journal of clinical investigation, 页码：2554-2569 , 文章类型： Article，,卷期：2011年121-7]
- STAT1 is the main signal transducer for type I and II IFNs and plays a central role in the regulation of innate and adaptive immune responses. We used Stat1-deficient mice to test the role of donor Stat1 in MHC-matched m...
- Engraftment of human nasal olfactory stem cells restores neuroplasticity in mice with hippocampal lesions
[作者：Nivet, E; Vignes, M; Girard, SD; Pierrisnard, C; Baril, N; Deveze, A; Magnan, J; Lante, F; Khrestchatisky, M; Feron, F; Roman, FS,期刊：Journal of clinical investigation, 页码：2808-2820 , 文章类型： Article，,卷期：2011年121-7]
- Stem cell-based therapy has been proposed as a potential means of treatment for a variety of brain disorders. Because ethical and technical issues have so far limited the clinical translation of research using embryonic/...
- Phosphodiesterase 4B in the cardiac L-type Ca2+ channel complex regulates Ca2+ current and protects against ventricular arrhythmias in mice
[作者：Leroy, J; Richter, W; Mika, D; Castro, LRV; Abi-Gerges, A; Xie, M; Scheitrum, C; Lefebvre, F; Schittl, J; Mateo, P; Westenbroek, R; Catterall, WA; Charpentier, F; Conti, M; Fischmeister, R; Vandecasteele, G,期刊：Journal of clinical investigation, 页码：2651-2661 , 文章类型： Article，,卷期：2011年121-7]
- beta-Adrenergic receptors (beta-ARs) enhance cardiac contractility by increasing cAMP levels and activating PKA. PKA increases Ca2+-induced Ca2+ release via phosphorylation of L-type Ca2+ channels (LTCCs) and ryanodine r...
- S6 kinase 1 is required for rapamycin-sensitive liver proliferation after mouse hepatectomy
[作者：Espeillac, C; Mitchell, C; Celton-Morizur, S; Chauvin, C; Koka, V; Gillet, C; Albrecht, JH; Desdouets, C; Pende, M,期刊：Journal of clinical investigation, 页码：2821-2832 , 文章类型： Article，,卷期：2011年121-7]
- Rapamycin is an antibiotic inhibiting eukaryotic cell growth and proliferation by acting on target of rapamycin (TOR) kinase. Mammalian TOR (mTOR) is thought to work through 2 independent complexes to regulate cell size ...
- Intrarenal dopamine deficiency leads to hypertension and decreased longevity in mice
[作者：Zhang, MZ; Yao, B; Wang, SW; Fan, XF; Wu, GQ; Yang, HC; Yin, HY; Yang, SL; Harris, RC,期刊：Journal of clinical investigation, 页码：2845-2854 , 文章类型： Article，,卷期：2011年121-7]
- In addition to its role as an essential neurotransmitter, dopamine serves important physiologic functions in organs such as the kidney. Although the kidney synthesizes dopamine through the actions of aromatic amino acid ...
- CCL17-expressing dendritic cells drive atherosclerosis by restraining regulatory T cell homeostasis in mice
[作者：Weber, C; Meiler, S; Doring, Y; Koch, M; Drechsler, M; Megens, RTA; Rowinska, Z; Bidzhekov, K; Fecher, C; Ribechini, E; van Zandvoort, MAMJ; Binder, CJ; Jelinek, V; Hristov, M; Boon, L; Jung, S; Korn, T; Lutz, MB; Forster, I; Zenke, M; Hieronymus, T; Junt, T; Zernecke, A,期刊：Journal of clinical investigation, 页码：2898-2910 , 文章类型： Article，,卷期：2011年121-7]
- Immune mechanisms are known to control the pathogenesis of atherosclerosis. However, the exact role of DCs, which are essential for priming of immune responses, remains elusive. We have shown here that the DC-derived che...
- Kruppel-like factor 4 regulates macrophage polarization
[作者：Liao, XD; Sharma, N; Kapadia, F; Zhou, GJ; Lu, Y; Hong, H; Paruchuri, K; Mahabeleshwar, GH; Dalmas, E; Venteclef, N; Flask, CA; Kim, J; Doreian, BW; Lu, KQ; Kaestner, KH; Hamik, A; Clement, K; Jain, MK,期刊：Journal of clinical investigation, 页码：2736-2749 , 文章类型： Article，,卷期：2011年121-7]
- Current paradigms suggest that two macrophage subsets, termed M1 and M2, are involved in inflammation and host defense. While the distinct functions of M1 and M2 macrophages have been intensively studied - the former are...
- Mouse and human lung fibroblasts regulate dendritic cell trafficking, airway inflammation, and fibrosis through integrin alpha v beta 8-mediated activation of TGF-beta
[作者：Kitamura, H; Cambier, S; Somanath, S; Barker, T; Minagawa, S; Markovics, J; Goodsell, A; Publicover, J; Reichardt, L; Jablons, D; Wolters, P; Hill, A; Marks, JD; Lou, JL; Pittet, JF; Gauldie, J; Baron, JL; Nishimura, SL,期刊：Journal of clinical investigation, 页码：2863-2875 , 文章类型： Article，,卷期：2011年121-7]
- The airway is a primary portal of entry for noxious environmental stimuli that can trigger airway remodeling, which contributes significantly to airway obstruction in chronic obstructive pulmonary disease (COPD) and chro...
- Multimodal silica nanoparticles are effective cancer-targeted probes in a model of human melanoma
[作者：Benezra, M; Penate-Medina, O; Zanzonico, PB; Schaer, D; Ow, H; Burns, A; DeStanchina, E; Longo, V; Herz, E; Iyer, S; Wolchok, J; Larson, SM; Wiesner, U; Bradbury, MS,期刊：Journal of clinical investigation, 页码：2768-2780 , 文章类型： Article，,卷期：2011年121-7]
- Nanoparticle-based materials, such as drug delivery vehicles and diagnostic probes, currently under evaluation in oncology clinical trials are largely not tumor selective. To be clinically successful, the next generation...
|