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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共50条记录   Duke/UNC to helm the JCI in March 2012 [作者：Neill, US,期刊：Journal of clinical investigation, 页码：2062-2062 , 文章类型： News Item，,卷期：2011年121-6] The three R's of lung health and disease: repair, remodeling, and regeneration [作者：Beers, MF; Morrisey, EE,期刊：Journal of clinical investigation, 页码：2065-2073 , 文章类型： Article，,卷期：2011年121-6] All tissues and organs can be classified according to their ability to repair and regenerate during adult homeostasis and after injury. Some exhibit a high rate of constant cell turnover, while others, such as the lung, ... Digging deeper into obesity [作者：Ahima, RS,期刊：Journal of clinical investigation, 页码：2076-2079 , 文章类型： Review，,卷期：2011年121-6] The growing problem of obesity is associated with multiple morbidities, including increased risk of diabetes, hypertension, heart disease, sleep apnea, and cancer. Obesity promotes disability, decreases productivity, and... Genetic approaches to understanding human obesity [作者：Ramachandrappa, S; Farooqi, IS,期刊：Journal of clinical investigation, 页码：2080-2086 , 文章类型： Review，,卷期：2011年121-6] Obesity and its associated comorbidities represent one of the biggest public health challenges facing the world today. The heritability of body weight is high, and genetic variation plays a major role in determining the ... Sixteen years and counting: an update on leptin in energy balance [作者：Gautron, L; Elmquist, JK,期刊：Journal of clinical investigation, 页码：2087-2093 , 文章类型： Review，,卷期：2011年121-6] Cloned in 1994, the ob gene encodes the protein hormone leptin, which is produced and secreted by white adipose tissue. Since its discovery, leptin has been found to have profound effects on behavior, metabolic rate, end... Adipose tissue remodeling and obesity [作者：Sun, K; Kusminski, CM; Scherer, PE,期刊：Journal of clinical investigation, 页码：2094-2101 , 文章类型： Review，,卷期：2011年121-6] To fulfill its role as the major energy-storing tissue, adipose has several unique properties that cannot be seen in any other organ, including an almost unlimited capacity to expand in a non-transformed state. As such, ... The role of lipid droplets in metabolic disease in rodents and humans [作者：Greenberg, AS; Coleman, RA; Kraemer, FB; McManaman, JL; Obin, MS; Puri, V; Yan, QW; Miyoshi, H; Mashek, DG,期刊：Journal of clinical investigation, 页码：2102-2110 , 文章类型： Review，,卷期：2011年121-6] Lipid droplets (LDs) are intracellular organelles that store neutral lipids within cells. Over the last two decades there has been a dramatic growth in our understanding of LD biology and, in parallel, our understanding ... Inflammatory links between obesity and metabolic disease [作者：Lumeng, CN; Saltiel, AR,期刊：Journal of clinical investigation, 页码：2111-2117 , 文章类型： Review，,卷期：2011年121-6] The obesity epidemic has forced us to evaluate the role of inflammation in the health complications of obesity. This has led to a convergence of the fields of immunology and nutrient physiology and the understanding that... Dynamics of insulin secretion and the clinical implications for obesity and diabetes [作者：Seino, S; Shibasaki, T; Minami, K,期刊：Journal of clinical investigation, 页码：2118-2125 , 文章类型： Review，,卷期：2011年121-6] Insulin secretion is a highly dynamic process regulated by various factors including nutrients, hormones, and neuronal inputs. The dynamics of insulin secretion can be studied at different levels: the single beta cell, p... Gut microbiome, obesity, and metabolic dysfunction [作者：Tilg, H; Kaser, A,期刊：Journal of clinical investigation, 页码：2126-2132 , 文章类型： Review，,卷期：2011年121-6] The prevalence of obesity and related disorders such as metabolic syndrome has vastly increased throughout the world. Recent insights have generated an entirely new perspective suggesting that our microbiota might be inv... Circadian rhythms, sleep, and metabolism [作者：Huang, WY; Ramsey, KM; Marcheva, B; Bass, J,期刊：Journal of clinical investigation, 页码：2133-2141 , 文章类型： Review，,卷期：2011年121-6] The discovery of the genetic basis for circadian rhythms has expanded our knowledge of the temporal organization of behavior and physiology. The observations that the circadian gene network is present in most living orga... The targeted podocyte [作者：Fogo, AB,期刊：Journal of clinical investigation, 页码：2142-2145 , 文章类型： Editorial Material，,卷期：2011年121-6] The podocyte plays a key role both in maintenance of the glomerular filtration barrier and in glomerular structural integrity. Podocyte injury and loss contribute to proteinuria and progressive sclerosis. Inhibitors of m... Spotlight on childhood blindness [作者：Sahel, JA,期刊：Journal of clinical investigation, 页码：2145-2149 , 文章类型： Editorial Material，,卷期：2011年121-6] Leber congenital amaurosis (LCA) is a rare disease that severely affects vision in early life. It is characterized by genetic and clinical heterogeneity due to complex and not fully understood pathogenetic mechanisms. It... From probiotics to therapeutics: another step forward? [作者：Ghishan, FK; Kiela, PR,期刊：Journal of clinical investigation, 页码：2149-2152 , 文章类型： Editorial Material，,卷期：2011年121-6] Preclinical studies with probiotics continue to unravel mechanisms of cytoprotection and suggest that approaches utilizing microbial products as therapeutics in acute and chronic gastrointestinal disorders could be effec... Neuroanatomy of body weight control: lessons learned from leptin [作者：Williams, DL; Schwartz, MW,期刊：Journal of clinical investigation, 页码：2152-2155 , 文章类型： Editorial Material，,卷期：2011年121-6] Rather than arising from the passive accumulation of excess calories, obesity is a state in which the biologically defended level of body fat stores increases due to defects in the homeostatic process that matches food i... Chronic lung allograft rejection and airway microvasculature: Is HIF-1 the missing link? [作者：Wilkes, DS,期刊：Journal of clinical investigation, 页码：2155-2157 , 文章类型： Editorial Material，,卷期：2011年121-6] Chronic lung allograft rejection, known as obliterative bronchiolitis (OB), is the leading cause of death in lung transplant patients. Although OB pathogenesis is not fully understood, in this issue of the JCI, Jiang and...