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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共48条记录   RNA sensor-induced type I IFN prevents diabetes caused by a beta cell-tropic virus in mice [作者：McCartney, SA; Vermi, W; Lonardi, S; Rossini, C; Otero, K; Calderon, B; Gilfillan, S; Diamond, MS; Unanue, ER; Colonna, M,期刊：Journal of clinical investigation, 页码：1497-1507 , 文章类型： Article，,卷期：2011年121-4] Viral infections have been linked to the onset of type I diabetes (T1D), with viruses postulated to induce disease directly by causing beta cell injury and subsequent release of autoantigens and indirectly via the host t... Liver mitochondrial membrane crosslinking and destruction in a rat model of Wilson disease [作者：Zischka, H; Lichtmannegger, J; Schmitt, S; Jagemann, N; Schulz, S; Wartini, D; Jennen, L; Rust, C; Larochette, N; Galluzzi, L; Chajes, V; Bandow, N; Gilles, VS; DiSpirito, AA; Esposito, I; Goettlicher, M; Summer, KH; Kroemer, G,期刊：Journal of clinical investigation, 页码：1508-1518 , 文章类型： Article，,卷期：2011年121-4] Wilson disease (WD) is a rare hereditary condition that is caused by a genetic defect in the copper-transporting ATPase ATP7B that results in hepatic copper accumulation and lethal liver failure. The present study focuse... Dysregulated brain creatine kinase is associated with hearing impairment in mouse models of Huntington disease [作者：Lin, YS; Chen, CM; Soong, BW; Wu, YR; Chen, HM; Yeh, WY; Wu, DR; Lin, YJ; Poon, PWF; Cheng, ML; Wang, CH; Chern, YJ,期刊：Journal of clinical investigation, 页码：1519-1523 , 文章类型： Article，,卷期：2011年121-4] Huntington disease (HD) is a degenerative disorder caused by expanded CAG repeats in exon 1 of the huntingtin gene (HTT). Patients with late-stage HD are known to have abnormal auditory processing, but the peripheral aud... A composite MyD88/CD40 switch synergistically activates mouse and human dendritic cells for enhanced antitumor efficacy [作者：Narayanan, P; Lapteva, N; Seethammagari, M; Levitt, JM; Slawin, KM; Spencer, DM,期刊：Journal of clinical investigation, 页码：1524-1534 , 文章类型： Article，,卷期：2011年121-4] The in vivo therapeutic efficacy of DC-based cancer vaccines is limited by suboptimal DC maturation protocols. Although delivery of TLR adjuvants systemically boosts DC-based cancer vaccine efficacy, it could also increa... IL-2 induces a WAVE2-dependent pathway for actin reorganization that enables WASp-independent human NK cell function [作者：Orange, JS; Roy-Ghanta, S; Mace, EM; Maru, S; Rak, GD; Sanborn, KB; Fasth, A; Saltzman, R; Paisley, A; Monaco-Shawver, L; Banerjee, PP; Pandey, R,期刊：Journal of clinical investigation, 页码：1535-1548 , 文章类型： Article，,卷期：2011年121-4] Wiskott-Aldrich syndrome (WAS) is a primary immunodeficiency associated with an increased susceptibility to herpesvirus infection and hematologic malignancy as well as a deficiency of NK cell function. It is caused by de... CD4(+) T cells from elite controllers resist HIV-1 infection by selective upregulation of p21 [作者：Chen, HB; Li, C; Huang, JH; Cung, T; Seiss, K; Beamon, J; Carrington, MF; Porter, LC; Burke, PS; Yang, Y; Ryan, BJ; Liu, RW; Weiss, RH; Pereyra, F; Cress, WD; Brass, AL; Rosenberg, ES; Walker, BD; Yu, XG; Lichterfeld, M,期刊：Journal of clinical investigation, 页码：1549-1560 , 文章类型： Article，,卷期：2011年121-4] Elite controllers represent a unique group of HIV-1-infected persons with undetectable HIV-1 replication in the absence of antiretroviral therapy. However, the mechanisms contributing to effective viral immune defense in... Impaired thymic tolerance to alpha-myosin directs autoimmunity to the heart in mice and humans [作者：Lv, HJ; Havari, E; Pinto, S; Gottumukkala, RVSRK; Cornivelli, L; Raddassi, K; Matsui, T; Rosenzweig, A; Bronson, RT; Smith, R; Fletcher, AL; Turley, SJ; Wucherpfennig, K; Kyewski, B; Lipes, MA,期刊：Journal of clinical investigation, 页码：1561-1561 , 文章类型： Article，,卷期：2011年121-4] Autoimmunity has long been linked to myocarditis and its sequela, dilated cardiomyopathy, the leading causes of heart failure in young patients. However, the underlying mechanisms are poorly defined, with most clinical i... Effective posttransplant antitumor immunity is associated with TLR-stimulating nucleic acid-immunoglobulin complexes in humans [作者：Lin, Y; Zhang, L; Cai, AX; Lee, M; Zhang, WD; Neuberg, D; Canning, CM; Soiffer, RJ; Alyea, EP; Ritz, J; Hacohen, N; Means, TK; Wu, CJ,期刊：Journal of clinical investigation, 页码：1574-1584 , 文章类型： Article，,卷期：2011年121-4] Donor lymphocyte infusion (DLI), whereby donor mononuclear cells are infused into patients, is one of the few effective immunotherapeutic strategies that generate long-lasting tumor remissions. We previously demonstrated... A Tbx1-Six1/Eya1-Fgf8 genetic pathway controls mammalian cardiovascular and craniofacial morphogenesis [作者：Guo, CS; Sun, Y; Zhou, B; Adam, RM; Li, XK; Pu, WT; Morrow, BE; Moon, A; Li, X,期刊：Journal of clinical investigation, 页码：1585-1595 , 文章类型： Article，,卷期：2011年121-4] Shared molecular programs govern the formation of heart and head during mammalian embryogenesis. Development of both structures is disrupted in human chromosomal microdeletion of 22q11.2 (del22q11), which causes DiGeorge... Single-cell Tsc1 knockout during corticogenesis generates tuber-like lesions and reduces seizure threshold in mice [作者：Feliciano, DM; Su, T; Lopez, J; Platel, JC; Bordey, A,期刊：Journal of clinical investigation, 页码：1596-1607 , 文章类型： Article，,卷期：2011年121-4] Tuberous sclerosis complex (TSC) is an autosomal dominant disorder characterized by mutations in Tsc1 or Tsc2 that lead to mammalian target of rapamycin (mTOR) hyperactivity. Patients with TSC suffer from intractable sei... Enhancing discovery and saving money with MERIT [作者：Epstein, JA,期刊：Journal of clinical investigation, 页码：1226-1226 , 文章类型： Editorial Material，,卷期：2011年121-4] The National Institutes of Health and many of our biomedical institutions face significant budgetary challenges that are likely to persist for the foreseeable future. The paylines for Research Project Grant (RO1) applica... Brian Druker and Charles Sawyers receive the 2011 ASCI/Stanley J. Korsmeyer Award [作者：Claiborn, K,期刊：Journal of clinical investigation, 页码：1227-1228 , 文章类型： News Item，,卷期：2011年121-4] Next-generation mTOR inhibitors in clinical oncology: how pathway complexity informs therapeutic strategy [作者：Wander, SA; Hennessy, BT; Slingerland, JM,期刊：Journal of clinical investigation, 页码：1231-1241 , 文章类型： Article，,卷期：2011年121-4] Mammalian target of rapamycin (mTOR) is a PI3K-related kinase that regulates cell growth, proliferation, and survival via mTOR complex 1 (mTORC1) and mTORC2. The mTOR pathway is often aberrantly activated in cancers. Whi... PinX1 the tail on the chromosome [作者：Johnson, FB,期刊：Journal of clinical investigation, 页码：1242-1244 , 文章类型： Editorial Material，,卷期：2011年121-4] The PinX1 protein inhibits telomerase, an enzyme that lengthens telomeres the structures that protect the ends of chromosomes. Loss of PinX1 leads to increased telomere length along with defects in chromosome dynamics. I... The adaptive stroma joining the antiangiogenic resistance front [作者：Casanovas, O,期刊：Journal of clinical investigation, 页码：1244-1247 , 文章类型： Editorial Material，,卷期：2011年121-4] Resistance to antiangiogenic therapies in cancer involves both tumor cells and stromal components, but their relative contributions differ in each cancer subtype. In this issue of the JCI, Cascone et al. describe a strom... Peripheral calcium-permeable AMPA receptors regulate chronic inflammatory pain in mice [作者：Gangadharan, V; Wang, R; Ulzhofer, B; Luo, C; Bardoni, R; Bali, KK; Agarwal, N; Tegeder, I; Hildebrandt, U; Nagy, GG; Todd, AJ; Ghirri, A; Haussler, A; Sprengel, R; Seeburg, PH; MacDermott, AB; Lewin, GR; Kuner, R,期刊：Journal of clinical investigation, 页码：1608-1623 , 文章类型： Article，,卷期：2011年121-4] alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-type (AMPA-type) glutamate receptors (AMPARs) play an important role in plasticity at central synapses. Although there is anatomical evidence for AMPAR expression ...