- Small-molecule inhibition of Wnt signaling through activation of casein kinase 1 alpha
[作者:THORNE CURTIS A; HANSON ALISON J; SCHNEIDER JUDSEN; TAHINCI EMILIOS; ORTON DARREN; CSELENYI CHRISTOPHER S; JERNIGAN KRISTIN K; MEYERS KELLY C; HANG BRIAN I; WATERSON ALEX G; KIM KWANGHO; MELANCON BRUCE; GHIDU VICTOR P; SULIKOWSKI GARY A; LAFLEUR BONNIE; SALIC ADRIAN; LEE LAURA A; MILLER DAVID M III; LEE ETHAN,期刊:NATURE CHEMICAL BIOLOGY, 页码:829-836 , 文章类型: Article,,卷期:2010年6-11]
- Wnt/beta-catenin signaling is critically involved in metazoan development, stem cell maintenance and human disease. Using Xenopus laevis egg extract to screen for compounds that both stabilize Axin and promote beta-caten...
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