- Crystal structure of glutamyl-queuosine tRNA(Asp) synthetase complexed with L-glutamate: Structural elements mediating tRNA-independent activation of glutamate and glutamylation of tRNA(Asp) anticodon
[作者：Blaise, M; Olieric, V; Sauter, C; Lorber, B; Roy, B; Karmakar, S; Banerjee, R; Becker, HD; Kern, D,期刊：Journal of Molecular Biology, 页码：1224-1237 , 文章类型： Article，,卷期：2008年381-5]
- Glutamyl-queuosine tRNA(Asp) synthetase (Glu-Q-RS) from Escherichia coli is a paralog of the catalytic core of glutamyl-tRNA synthetase (GluRS) that catalyzes glutamylation of queuosine in the wobble position of tRNA(Asp...
- Crystal structures of multiple GATA zinc fingers bound to DNA reveal new insights into DNA recognition and self-association by GATA
[作者：Bates, DL; Chen, YH; Kim, G; Guo, L; Chen, L,期刊：Journal of Molecular Biology, 页码：1292-1306 , 文章类型： Article，,卷期：2008年381-5]
- The GATA family of transcription factors (GATA1-6) binds selected GATA sites in vertebrate genomes to regulate specific gene expression. Although vertebrate GATA factors have two highly conserved zinc finger motifs, how ...
- Structural determinants of the ADAM inhibition by TIMP-3: Crystal structure of the TACE-N-TIMP-3 complex
[作者：Wisniewska, M; Goettig, P; Maskos, K; Belouski, E; Winters, D; Hecht, R; Black, R; Bode, W,期刊：Journal of Molecular Biology, 页码：1307-1319 , 文章类型： Article，,卷期：2008年381-5]
- TIMP-3 (tissue inhibitor of metalloproteinases 3) is unique among the TIMP inhibitors, in that it effectively inhibits the TNF-alpha converting enzyme (TACE). In order to understand this selective capability of inhibitio...
- Ligand binding mode of GABA(A) receptor-associated protein
[作者：Weiergraber, OH; Stangler, T; Thielmann, Y; Mohrluder, J; Wiesehan, K; Willbold, D,期刊：Journal of Molecular Biology, 页码：1320-1331 , 文章类型： Article，,卷期：2008年381-5]
- The gamma-aminobutyric acid type A (GABA(A)) receptor-associated protein is a versatile adaptor protein playing an important role in intracellular vesicle trafficking, particularly in neuronal cells. We present the X-ray...
- The crystal structure of UMP kinase from Bacillus anthracis (BA1797) reveals an allosteric nucleotide-binding site
[作者：Meier, C; Carter, LG; Sainsbury, S; Mancini, EJ; Owens, RJ; Stuart, DI; Esnouf, RM,期刊：Journal of Molecular Biology, 页码：1098-1105 , 文章类型： Article，,卷期：2008年381-5]
Uridine monophosphate (UMP) kinase is a conserved enzyme that catalyzes the ATP-driven conversion of uridylate monophosphate into uridylate diphosphate, an essential metabolic step. In prokaryotes, the enzyme exists a...
- Picomolar affinity fibronectin domains engineered utilizing loop length diversity, recursive mutagenesis, and loop shuffling
[作者：Hackel, BJ; Kapila, A; Wittrup, KD,期刊：Journal of Molecular Biology, 页码：1238-1252 , 文章类型： Article，,卷期：2008年381-5]
- The 10th type III domain of human fibronectin (Fn3) has been validated as an effective scaffold for molecular recognition. In the current work, it was desired to improve the robustness of selection of stable, high-affini...
- DNA packaging motor assembly intermediate of bacteriophage phi 29
[作者：Koti, JS; Morais, MC; Rajagopal, R; Owen, BAL; McMurray, CT; Anderson, DL,期刊：Journal of Molecular Biology, 页码：1114-1132 , 文章类型： Article，,卷期：2008年381-5]
- Unraveling the structure and assembly of the DNA packaging ATPases of the tailed double-stranded DNA bacteriophages is integral to understanding the mechanism of DNA translocation. Here, the bacteriophage ( 29 packaging ...
- Force-based analysis of multidimensional energy landscapes: Application of dynamic force spectroscopy and steered molecular dynamics simulations to an antibody fragment-peptide complex
[作者：Morfill, J; Neumann, J; Blank, K; Steinbach, U; Puchner, EM; Gottschalk, KE; Gaub, HE,期刊：Journal of Molecular Biology, 页码：1253-1266 , 文章类型： Article，,卷期：2008年381-5]
- Multidimensional energy landscapes are an intrinsic property of proteins and define their dynamic behavior as well as their response to external stimuli. In order to explore the energy landscape and its implications on t...
- Kinetics of fibril formation of bovine kappa-casein indicate a conformational rearrangement as a critical step in the process
[作者：Leonil, J; Henry, G; Jouanneau, D; Delage, MM; Forge, V; Putaux, JL,期刊：Journal of Molecular Biology, 页码：1267-1280 , 文章类型： Article，,卷期：2008年381-5]
- S-carboxymethylated (SCM) kappa-casein forms in vitro fibrils that display several characteristics of amyloid fibrils, although the protein is unrelated to amyloid diseases. In order to get insight into the processes tha...
- Reversible sheet-turn conformational change of a cell-penetrating peptide in lipid bilayers studied by solid-state NMR
[作者：Su, YC; Mani, R; Doherty, T; Waring, AJ; Hong, M,期刊：Journal of Molecular Biology, 页码：1133-1144 , 文章类型： Article，,卷期：2008年381-5]
- The membrane-bound conformation of a cell-penetrating peptide, penetratin, is investigated using solid-state NMR spectroscopy. The C-13 chemical shifts of C-13, N-15-labeled residues in the peptide indicate a reversible ...
- An allosteric circuit in caspase-1
[作者：Datta, D; Scheer, JM; Romanowski, MJ; Wells, JA,期刊：Journal of Molecular Biology, 页码：1157-1167 , 文章类型： Article，,卷期：2008年381-5]
- Structural studies of caspase-1 reveal that the dimeric thiol protease can exist in two states: in an on-state, when the active site is occupied, or in an off-state, when the active site is empty or when the enzyme is bo...
- Cholesterol effects on BAX pore activation
[作者：Christenson, E; Merlin, S; Saito, M; Schlesinger, P,期刊：Journal of Molecular Biology, 页码：1168-1183 , 文章类型： Article，,卷期：2008年381-5]
- The importance of BCL-2 family proteins in the control of cell death has been clearly established. One of the key members of this family, BAX, has soluble, membrane-bound, and membrane-integrated forms that are central t...
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