- The GANC Tetraloop: A Novel Motif in the Group IIC Intron Structure
[作者:Keating, KS; Toor, N; Pyle, AM,期刊:Journal of Molecular Biology, 页码:475-481 , 文章类型: Article,,卷期:2008年383-3]
- Tetraloops are a common building block for RNA tertiary structure, and most tetraloops fall into one of three well-characterized classes: GNRA, UNCG, and CUYG. Here, we present the sequence and structure of a fourth high...
- Crystal Structure of Mycobacterium tuberculosis YefM Antitoxin Reveals that it is Not an Intrinsically Unstructured Protein
[作者:Kumar, P; Issac, B; Dodson, EJ; Turkenburg, JP; Mande, SC,期刊:Journal of Molecular Biology, 页码:482-493 , 文章类型: Article,,卷期:2008年383-3]
- Toxin-antitoxin modules are present on chromosomes of almost all free-living prokaryotes. Some are implicated to act as stress-responsive elements, among their many functional roles. The YefM-YoeB toxin-antitoxin system ...
- Roles of the Minor Capsid Protein P7 in the Assembly and Replication of Double-Stranded RNA Bacteriophage phi 6
[作者:Poranen, MM; Butcher, SJ; Simonov, VM; Laurinmaki, P; Bamford, DH,期刊:Journal of Molecular Biology, 页码:529-538 , 文章类型: Article,,卷期:2008年383-3]
- The polymerase complexes of double-stranded RNA (dsRNA) viruses are multifunctional RNA processing machineries that carry out viral genome packaging, replication, and transcription. The polymerase complex forms the inner...
- The Crystal Structure of the C-Terminal DAP5/p97 Domain Sheds Light on the Molecular Basis for Its Processing by Caspase Cleavage
[作者:Liberman, N; Dym, O; Unger, T; Albeck, S; Peleg, Y; Jacobovitch, Y; Branzburg, A; Eisenstein, M; Marash, L; Kimchi, A,期刊:Journal of Molecular Biology, 页码:539-548 , 文章类型: Article,,卷期:2008年383-3]
- DAP5/p97 (death-associated protein 5) is a member of the eukaryotic translation initiation factor 4G family. It functions as a scaffold protein promoting cap-independent translation of proteins. During apoptosis, DAP5/p9...
- Assembly Architecture and DNA Binding of the Bacteriophage P22 Terminase Small Subunit
[作者:Nemecek, D; Lander, GC; Johnson, JE; Casjens, SR; Thomas, GJ,期刊:Journal of Molecular Biology, 页码:494-501 , 文章类型: Article,,卷期:2008年383-3]
- Morphogenesis of bacteriophage P22 involves the packaging of double-stranded DNA into a preassembled procapsid. DNA is translocated by a powerful virally encoded molecular motor called terminase, which comprises large (g...
- Upstream Stimulatory Factors Regulate OSCAR Gene Expression in RANKL-Mediated Osteoclast Differentiation
[作者:Kim, JH; Kim, K; Jin, HM; Youn, BU; Song, I; Choi, HS; Kim, N,期刊:Journal of Molecular Biology, 页码:502-511 , 文章类型: Article,,卷期:2008年383-3]
- Receptor activator of nuclear factor kappa B ligand (RANKL) induces osteoclast differentiation from hematopoietic precursors via regulation of various transcription factors. Here, we show that upstream stimulatory factor...
- Functional and Structural Characterization of the Arylamine N-Acetyltransferase from the Opportunistic Pathogen Nocardia farcinica
[作者:Martins, M; Pluvinage, B; de la Sierra-Gallay, IL; Barbault, F; Dairou, J; Dupret, JM; Rodrigues-Lima, F,期刊:Journal of Molecular Biology, 页码:549-560 , 文章类型: Article,,卷期:2008年383-3]
- Arylamine N-acetyltransferase (NAT) enzymes are found in a broad range of eukaryotes and prokaryotes. There is increasing evidence that NAT enzymes could contribute to antibiotic resistance in pathogenic bacteria such as...
- Crystal-Structure and Biochemical Characterization of Recombinant Human Calcyphosine Delineates a Novel EF-Hand-Containing Protein Family
[作者:Dong, H; Li, X; Lou, ZY; Xu, XL; Su, D; Zhou, XH; Zhou, WH; Bartlam, M; Rao, ZH,期刊:Journal of Molecular Biology, 页码:455-464 , 文章类型: Article,,卷期:2008年383-3]
- Calcyphosine is an EF-hand protein involved in both Ca2+ -phosphatidylinositol and cyclic AMP signal cascades, as well as in other cellular functions. The crystal structure of Ca2+ -loaded calcyphosine was determined up ...
- Structural and Molecular Characterization of the Prefoldin beta Subunit from Thermococcus Strain KS-1
[作者:Kida, H; Sugano, Y; Lizuka, R; Fujihashi, M; Yohda, M; Miki, K,期刊:Journal of Molecular Biology, 页码:465-474 , 文章类型: Article,,卷期:2008年383-3]
- Prefoldin (PFD) is a heterohexameric molecular chaperone that is found in eukaryotic cytosol and archaea. PFD is composed of alpha and beta subunits and forms a "jellyfish-like" structure. PFD binds and stabilizes nascen...
- Crystal Structure of CYP199A2, a Para-Substituted Benzoic Acid Oxidizing Cytochrome P450 from Rhodopseudomonas palustris
[作者:Bell, SG; Xu, F; Forward, I; Bartlam, M; Rao, ZH; Wong, LL,期刊:Journal of Molecular Biology, 页码:561-574 , 文章类型: Article,,卷期:2008年383-3]
- CYP199A2, a cytochrome P450 enzyme from Rhodopseudomonas palustris, oxidatively demethylates 4-methoxybenzoic acid to 4-hydroxybenzoic acid. 4-Ethylbenzoic acid is converted to a mixture of predominantly 4-(1-hydroxyethy...
- Structural Analysis of the Human Rad51 Protein-DNA Complex Filament by Tryptophan Fluorescence Scanning Analysis: Transmission of Allosteric Effects between ATP Binding and DNA Binding
[作者:Renodon-Corniere, A; Takizawa, Y; Conilleau, S; Tran, V; Iwai, S; Kurumizaka, H; Takahashi, M,期刊:Journal of Molecular Biology, 页码:575-587 , 文章类型: Article,,卷期:2008年383-3]
- Human Rad51 (HsRad51) catalyzes the strand exchange reaction, a crucial step in homologous recombination, by forming a filamentous complex with DNA. The structure of this filament is modified by ATP, which is required an...
- Crystal Structure of the Escherichia coli 23S rRNA:m(5)C Methyltransferase RlmI (YccW) Reveals Evolutionary Links between RNA Modification Enzymes
[作者:Sunita, S; Tkaczuk, KL; Purta, E; Kasprzak, JM; Douthwaite, S; Bujnicki, JM; Sivaraman, J,期刊:Journal of Molecular Biology, 页码:652-666 , 文章类型: Article,,卷期:2008年383-3]
- Methylation is the most common RNA modification in the three domains of life. Transfer of the methyl group from S-adenosyl-L-methionine (AdoMet) to specific atoms of RNA nucleotides is catalyzed by methyltransferase (MTa...
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