- Probing the Role of Aromatic Residues at the Secondary Saccharide-Binding Sites of Human Salivary alpha-Amylase in Substrate Hydrolysis and Bacterial Binding
[作者:Ragunath, C; Manuel, SGA; Venkataraman, V; Sait, HBR; Kasinathan, C; Ramasubbu, N,期刊:Journal of Molecular Biology, 页码:1232-1248 , 文章类型: Article,,卷期:2008年384-5]
- Human salivary (x-amylase (HSAmy) has three distinct functions relevant to oral health: (1) hydrolysis of starch, (2) binding to hydroxyapatite (HA), and (3) binding to bacteria (e.g., viridans streptococci). Although th...
- Two Levels of Cooperativeness in the Binding of TodT to the tod Operon Promoter
[作者:Lacal, J; Guazzaroni, ME; Gutierrez-del-Arroyo, P; Busch, A; Velez, M; Krell, T; Ramos, JL,期刊:Journal of Molecular Biology, 页码:1037-1047 , 文章类型: Article,,卷期:2008年384-5]
- The TodS/TodT two-component system controls the expression of nod genes for toluene degradation in Pseudomonas putida. TodT binds to two pseudopalindromes at -106 (Box-1) and -85 (Box-2), as well as to a half-palindrome ...
- Structure and Regulatory Mechanism of Aquifex aeolicus NtrC4: Variability and Evolution in Bacterial Transcriptional Regulation
[作者:Batchelor, JD; Doucleff, M; Lee, CJ; Matsubara, K; De Carlo, S; Heideker, J; Lamers, MH; Pelton, JG; Wemmer, DE,期刊:Journal of Molecular Biology, 页码:1058-1075 , 文章类型: Article,,卷期:2008年384-5]
- Genetic changes lead gradually to altered protein function, making deduction of the molecular basis for activity from a sequence difficult. Comparative studies provide insights into the functional consequences of specifi...
- Mismatched Base-Pair Simulations for ASFV Pol x/DNA Complexes Help Interpret Frequent G.G Misincorporation
[作者:Benitez, BAS; Arora, K; Balistreri, L; Schlick, T,期刊:Journal of Molecular Biology, 页码:1086-1097 , 文章类型: Article,,卷期:2008年384-5]
- DNA polymerase X (pot X) from the African swine fever virus is a 1.74-amino-acid repair polymerase that likely participates in a viral base excision repair mechanism, characterized by low fidelity. Surprisingly, pot X's ...
- Generation, Affinity Maturation, and Characterization of a Human Anti-Human NKG2D Monoclonal Antibody with Dual Antagonistic and Agonistic Activity
[作者:Kwong, KY; Baskar, S; Zhang, H; Mackall, CL; Rader, C,期刊:Journal of Molecular Biology, 页码:1143-1156 , 文章类型: Article,,卷期:2008年384-5]
- In humans, NKG2D is an activating receptor on natural killer (NK) cells and a costimulatory receptor on certain T cells and plays a central role in mediating immune responses in autoimmune diseases, infectious diseases, ...
- The Crystal Structure of CD8 in Complex with YTS156.7.7 Fab and Interaction with Other CD8 Antibodies Define the Binding Mode of CD8 alpha beta to MHC Class I
[作者:Shore, DA; Issafras, H; Landais, E; Teyton, L; Wilson, IA,期刊:Journal of Molecular Biology, 页码:1190-1202 , 文章类型: Article,,卷期:2008年384-5]
- The CD8 alpha beta heterodimer interacts with class I pMHC on antigen-presenting cells as a co-receptor for TCR-mediated activation of cytotoxic T cells. To characterize this immunologically important interaction, we use...
- Crystal Structure of Vascular Endothelial Growth Factor-B in Complex with a Neutralising Antibody Fab Fragment
[作者:Leonard, P; Scotney, PD; Jabeen, T; Iyer, S; Fabri, LJ; Nash, AD; Acharya, KR,期刊:Journal of Molecular Biology, 页码:1203-1217 , 文章类型: Article,,卷期:2008年384-5]
- Vascular endothelial growth factor (VEGF) B effects blood vessel formation by binding to VEGF receptor 1. To study the specifics of the biological profile of VEGF-B in both physiological and pathological angiogenesis, a ...
- The Structure of Monoamine Oxidase from Aspergillus niger Provides a Molecular Context for Improvements in Activity Obtained by Directed Evolution
[作者:Atkin, KE; Reiss, R; Koehler, V; Bailey, KR; Hart, S; Turkenburg, JP; Turner, NJ; Brzozowski, AM; Grogan, G,期刊:Journal of Molecular Biology, 页码:1218-1231 , 文章类型: Article,,卷期:2008年384-5]
- Monoamine oxidase from Aspeigillus niger (MAO-N) is a flavoenzyme that catalyses the oxidative deamination of primary amines. MAO-N has been used as the starting model for a series of directed evolution experiments, resu...
- Long-Range Enhancer Differentially Regulated by c-Jun and JunD Controls Peptidylarginine Deiminase-3 Gene in Keratinocytes
[作者:Adoue, V; Chavanas, S; Coudane, F; Mechin, MC; Caubet, C; Ying, SB; Dong, SJ; Duplan, H; Charveron, M; Takahara, H; Serre, G; Simon, M,期刊:Journal of Molecular Biology, 页码:1048-1057 , 文章类型: Article,,卷期:2008年384-5]
- Long-range cis elements are critical regulators of transcription, particularly for clustered paralogous genes. Such are the five PADI genes in 1p35-36 encoding peptidylarginine deiminases, which catalyze deimination, a C...
- Lagging Strand-Biased Initiation of Red Recombination by Linear Double-Stranded DNAS
[作者:Lim, SI; Min, BE; Jung, GY,期刊:Journal of Molecular Biology, 页码:1098-1105 , 文章类型: Article,,卷期:2008年384-5]
- The recombination functions of the lambda bacteriophage, collectively called Red, can be exploited for simple and specific in vivo genetic manipulations of Escherichia coli, which is of great use in functional genomics, ...
- Hsp104 Targets Multiple Intermediates on the Amyloid Pathway and Suppresses the Seeding Capacity of A beta Fibrils and Protofibrils
[作者:Arimon, M; Grimminger, V; Sanz, F; Lashuel, HA,期刊:Journal of Molecular Biology, 页码:1157-1173 , 文章类型: Article,,卷期:2008年384-5]
- The heat shock protein Hsp104 has been reported to possess the ability to. modulate protein aggregation and toxicity and to "catalyze" the disaggregation and recovery of protein aggregates, including amyloid fibrils, in ...
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