- Contribution of p38 MAPK, NF-kappa B and glucocorticoid signaling pathways to ER stress-induced increase in retinal endothelial permeability
[作者:Adachi, T; Teramachi, M; Yasuda, H; Kamiya, T; Hara, H,期刊:Archives of Biochemistry and Biophysics , 页码:30-35 , 文章类型: Article,,卷期:2012年520-1]
- Diabetic retinopathy (DR) is characterized by the development of intraretinal microvascular abnormalities. Endoplasmic reticulum (ER) stress is known to play a pathogenic role in vascular impairment in DR. The present st...
- Allosteric activation of human alpha-thrombin through exosite 2 by suramin analogs
[作者:Cargnelutti, MT; Marques, AF; Esser, D; Monteiro, RQ; Kassack, MU; Lima, LMTR,期刊:Archives of Biochemistry and Biophysics , 页码:36-41 , 文章类型: Article,,卷期:2012年520-1]
- Thrombin is a serine protease that plays fundamental roles in hemostasis. We have recently elucidated the crystal structure of thrombin in complex with suramin, evidencing the interaction through the anion binding exosit...
- HPLC analysis of tetrahydrobiopterin and its pteridine derivatives using sequential electrochemical and fluorimetric detection: Application to tetrahydrobiopterin autoxidation and chemical oxidation
[作者:Biondi, R; Ambrosio, G; De Pascali, F; Tritto, I; Capodicasa, E; Druhan, LJ; Hemann, C; Zweier, JL,期刊:Archives of Biochemistry and Biophysics , 页码:7-16 , 文章类型: Article,,卷期:2012年520-1]
- Tetrahydrobiopterin (BH4) is an essential cofactor of endothelial nitric oxide (NO) synthase and when depleted, endothelial dysfunction results with decreased production of NO. BH4 is also an anti-oxidant being a good "s...
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